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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第105巻第4号

液体培養における顆粒球(G-CSF)および顆粒球・マクロファージコロニー刺激因子(GM-CSF)のヒト白血病細胞におよぼす影響

http://hdl.handle.net/10191/38772
http://hdl.handle.net/10191/38772
7119c340-8c64-4e52-a5b8-91297b8b3ea2
名前 / ファイル ライセンス アクション
105(4)_254-262.pdf 105(4)_254-262.pdf (1.9 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-02-26
タイトル
タイトル 液体培養における顆粒球(G-CSF)および顆粒球・マクロファージコロニー刺激因子(GM-CSF)のヒト白血病細胞におよぼす影響
タイトル
言語 en
タイトル 液体培養における顆粒球(G-CSF)および顆粒球・マクロファージコロニー刺激因子(GM-CSF)のヒト白血病細胞におよぼす影響
言語
言語 jpn
キーワード
主題Scheme Other
主題 Human leukemic cell
キーワード
主題Scheme Other
主題 G-CSF
キーワード
主題Scheme Other
主題 GM-CSF
キーワード
主題Scheme Other
主題 In vitro liquid culture
キーワード
主題Scheme Other
主題 ヒト白血病細胞
キーワード
主題Scheme Other
主題 液体培養
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Effects of Granulocyte Colony-Stimulating Factor (G-CSF) and Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) on Human Leukemic Cells in Liquid Culture
著者 今成, 朗

× 今成, 朗

WEKO 131287

今成, 朗

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著者別名
識別子 131288
識別子Scheme WEKO
姓名 Imanari, Akira
抄録
内容記述タイプ Abstract
内容記述 The effect of granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) on human acute myeloid lukemia cells was examined in vitro. Mononuclear cells obtained from bone marrow or peripheral blood cells of 22 patients with acute myeloid leukemia were incubated in liquid culture system with and without CSFs. In two of 22 cases, leukemic cells proliferated wihout CSFs. G-CSF stimulated the proliferation of leukemic cells from eight of 22 patients and GM-CSF did from seven of fifteen patients. This stimulation by CSFs appeared to be dose-dependent. In addition, additive and synergistic effects were observed in four of eleven leukemic cells stimulated with combined G-CSF and GM-CSF in vitro. Only one case showed differentiation with G-CSF. Out of nine patients given G-CSF clinically, three showed in vitro growth of their leukemic cells. In one patient with a striking cell proliferation by both CSFs in vitro, his leukemic cells incresed in number after the administration of G-CSF (iv). These observations suggest that leukemic clone may have some sensitivity to CSFs in vitro and in vivo. Thus, in vitro culture to see which leukemic cells can respond to CSFs in vitro seems to be necessary before CSF administration in vivo.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 105, 号 4, p. 254-262, 発行日 1991-04
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
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