{"created":"2021-03-01T06:26:31.632682+00:00","id":21473,"links":{},"metadata":{"_buckets":{"deposit":"af3e126b-2b47-4cc4-b357-da1235f5f8a2"},"_deposit":{"id":"21473","owners":[],"pid":{"revision_id":0,"type":"depid","value":"21473"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00021473","sets":["453:456","471:537:538:1187"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Effects of Granulocyte Colony-Stimulating Factor （G-CSF） and Granulocyte-Macrophage Colony-Stimulating Factor （GM-CSF） on Human Leukemic Cells in Liquid Culture"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"262","bibliographicPageStart":"254","bibliographicVolumeNumber":"105","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The effect of granulocyte colony-stimulating factor （G-CSF） and granulocyte-macrophage colony-stimulating factor （GM-CSF） on human acute myeloid lukemia cells was examined in vitro. Mononuclear cells obtained from bone marrow or peripheral blood cells of 22 patients with acute myeloid leukemia were incubated in liquid culture system with and without CSFs. In two of 22 cases, leukemic cells proliferated wihout CSFs. G-CSF stimulated the proliferation of leukemic cells from eight of 22 patients and GM-CSF did from seven of fifteen patients. This stimulation by CSFs appeared to be dose-dependent. In addition, additive and synergistic effects were observed in four of eleven leukemic cells stimulated with combined G-CSF and GM-CSF in vitro. Only one case showed differentiation with G-CSF. Out of nine patients given G-CSF clinically, three showed in vitro growth of their leukemic cells. In one patient with a striking cell proliferation by both CSFs in vitro, his leukemic cells incresed in number after the administration of G-CSF （iv）. These observations suggest that leukemic clone may have some sensitivity to CSFs in vitro and in vivo. Thus, in vitro culture to see which leukemic cells can respond to CSFs in vitro seems to be necessary before CSF administration in vivo.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"131288","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Imanari, Akira"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"今成, 朗"}],"nameIdentifiers":[{"nameIdentifier":"131287","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-16"}],"displaytype":"detail","filename":"105(4)_254-262.pdf","filesize":[{"value":"1.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"105(4)_254-262.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/21473/files/105(4)_254-262.pdf"},"version_id":"55b1f309-d895-44e8-bd4a-0b59a1826105"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Human leukemic cell","subitem_subject_scheme":"Other"},{"subitem_subject":"G-CSF","subitem_subject_scheme":"Other"},{"subitem_subject":"GM-CSF","subitem_subject_scheme":"Other"},{"subitem_subject":"In vitro liquid culture","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒト白血病細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"液体培養","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"液体培養における顆粒球（G-CSF）および顆粒球・マクロファージコロニー刺激因子（GM-CSF）のヒト白血病細胞におよぼす影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"液体培養における顆粒球（G-CSF）および顆粒球・マクロファージコロニー刺激因子（GM-CSF）のヒト白血病細胞におよぼす影響"},{"subitem_title":"液体培養における顆粒球（G-CSF）および顆粒球・マクロファージコロニー刺激因子（GM-CSF）のヒト白血病細胞におよぼす影響","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1187"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-02-26"},"publish_date":"2016-02-26","publish_status":"0","recid":"21473","relation_version_is_last":true,"title":["液体培養における顆粒球（G-CSF）および顆粒球・マクロファージコロニー刺激因子（GM-CSF）のヒト白血病細胞におよぼす影響"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:52:02.404942+00:00"}