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ラットの行動および脳内ニューロテンシン様免疫活性に及ぼす精神刺激薬の効果に関する研究
http://hdl.handle.net/10191/39579
http://hdl.handle.net/10191/39579785b515c-6e16-4d39-9c85-c4beee356db8
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
106(03)_221-232.pdf (2.6 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-03-14 | |||||
| タイトル | ||||||
| タイトル | ラットの行動および脳内ニューロテンシン様免疫活性に及ぼす精神刺激薬の効果に関する研究 | |||||
| タイトル | ||||||
| タイトル | ラットの行動および脳内ニューロテンシン様免疫活性に及ぼす精神刺激薬の効果に関する研究 | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | phencyclidine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | methamphetamine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | neurotensin-like immunoreactivity | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | abnormal behavior | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | フェンサイクリジン | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | メトアンフェタミン | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ニューロテンシン様免疫活性 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 異常行動 | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| その他のタイトル | ||||||
| その他のタイトル | Effects of Psychostimulants Administration on Behavior and Brain Neurotensin-Like Immunoreactivity in Rats | |||||
| 著者 |
和知, 学
× 和知, 学 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 129376 | |||||
| 姓名 | Wachi, Manabu | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The effects of psychostimulants (methamphetamine and phencyclidine) on behavior and brain neurotensin-like immunoreactivity (NTLI) were investigated in rats. The following results were obtained：(1) Acute administration of phencyclidine (PCP) to rats induced a complex behavioral pattern which consisted of high locomotor activity, stereotyped behavior and ataxia. After 10 days of chronic PCP administration, PCP-induced stereotypy and ataxia decreased but the locomotor activity increased； (2) In frontal cortex (Fc), NTLI decreased significantly in both the acute and chronic PCP groups； (3) Chronic administration of methamphetamine (MAP) to rats produced progressive augmentation in response, characterized by a more rapid onset and an increased magnitude of stereotypy； (4) After a dose of 10mg/kg/day of MAP had been given for 5, 10 and 20 days, NTLI in limbic forebrain (LF) significantly increased from 14.6pg/mg wet weight (control) to 21.2 (5 days), 23.7 (10 days) and 22.8 (20 days). Similar results were also observed in caudate putamen (CP) and midbrain (MB)； (5) When rats were administered MAP (50mg/kg) and sacrificed after 1, 6, 12, 24, 36 and 48h, the increase in NTLI in LF became evident first at 12h and persisted through 24h. NTLI in the CP began to increase at 6h after the MAP injection. This increase persisted for at least an additional 30h. In the MB, NTLI significantly increased from 24 to 36h after MAP administration； (6) The increase of NTLI in LF, CP and MB were dependent on the dose of MAP. Possible participation of dopaminergic innervation on these effects of psychostimulants was discussed. | |||||
| 書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 106, 号 3, p. 221-232, 発行日 1992-03 |
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| 出版者 | ||||||
| 出版者 | 新潟医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00290440 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00182415 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
