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Adenosine 5'-monophosphate(AMP)のモルモット摘出胸部大動脈弛緩作用について
http://hdl.handle.net/10191/39575
http://hdl.handle.net/10191/39575a5c07678-4ac9-4941-b886-70f86d0b892c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
106(03)_188-195.pdf (1.7 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-03-14 | |||||
| タイトル | ||||||
| タイトル | Adenosine 5'-monophosphate(AMP)のモルモット摘出胸部大動脈弛緩作用について | |||||
| タイトル | ||||||
| タイトル | Adenosine 5'-monophosphate(AMP)のモルモット摘出胸部大動脈弛緩作用について | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | guinea pig thoracic aorta | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | AMP | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | adenosine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 5'-nucleotidase | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | AOPCP | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | モルモット胸部大動脈 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | アデノシン | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| その他のタイトル | ||||||
| その他のタイトル | Mechanisms of Adenosine 5'-Monophosphate-induced Relaxation in the Isolated Guinea Pig Thoracic Aorta | |||||
| 著者 |
今井, 裕久
× 今井, 裕久 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 129368 | |||||
| 姓名 | Imai, Hirohisa | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In order to investigate whether a relaxation potency of adenosine 5'-monophosphate (AMP) is comparable to that of adenosine, isolated guinea pig thoracic aortas precontracted with phenylephrine were used. In order to examine the direct relaxant effect on the smooth muscle, all preparations were deprived of endothelial layer by rubbing. Adenosine induced concentrationdependent relaxations in the aorta with an ED_<50> value of 1.0×10^<-4>M. The concentration-relaxation curve for adenosine was shifted to the left with 2×10^<-5> M of erythro-9-(2-hydroxy-3-nonyl) adenine (EHNA), an adenosine deaminase inhibitor. This concentration of EHNA caused 97% inhibition of adenosine degradation to inosine in the aorta. Relaxation by adenosine was inhibited with 8-phenyltheophylline (8-PT), a P_1 purinoceptor inhibitor. AMP caused concentration-dependent relaxations in the aorta with an ED_<50> value of 1.2×10^<-4>M, a value which was comparable to that of adenosine. AMP-induced relaxation was also potentiated by EHNA treatment. α, β-methylene adenosine diphosphate (AOPCP), an ecto-5'-nucleotidase inhibitor, caused no effect on adenosine-induced relaxation, while it inhibited AMP-induced relaxation around 80%. The concentration of AOPCP used in this experiment. inhibited AMP degaradation in the aorta by 50 to 85%. These results suggest that AMP-induced relaxation is due to adenosine produced through ecto-5'-nucleotidase pathway and the relaxation potency of AMP itself is very weak. | |||||
| 書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 106, 号 3, p. 188-195, 発行日 1992-03 |
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| 出版者 | ||||||
| 出版者 | 新潟医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00290440 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00182415 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
