{"created":"2021-03-01T06:26:06.626266+00:00","id":21093,"links":{},"metadata":{"_buckets":{"deposit":"6c53e977-6b43-4d78-8875-7b3da0f665be"},"_deposit":{"id":"21093","owners":[],"pid":{"revision_id":0,"type":"depid","value":"21093"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00021093","sets":["453:456","471:537:538:1176"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Mechanisms of Adenosine 5'-Monophosphate-induced Relaxation in the Isolated Guinea Pig Thoracic Aorta"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1992-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"195","bibliographicPageStart":"188","bibliographicVolumeNumber":"106","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In order to investigate whether a relaxation potency of adenosine 5'-monophosphate (AMP) is comparable to that of adenosine, isolated guinea pig thoracic aortas precontracted with phenylephrine were used. In order to examine the direct relaxant effect on the smooth muscle, all preparations were deprived of endothelial layer by rubbing. Adenosine induced concentrationdependent relaxations in the aorta with an ED_<50> value of 1.0×10^<-4>M. The concentration-relaxation curve for adenosine was shifted to the left with 2×10^<-5> M of erythro-9-(2-hydroxy-3-nonyl) adenine (EHNA), an adenosine deaminase inhibitor. This concentration of EHNA caused 97% inhibition of adenosine degradation to inosine in the aorta. Relaxation by adenosine was inhibited with 8-phenyltheophylline (8-PT), a P_1 purinoceptor inhibitor. AMP caused concentration-dependent relaxations in the aorta with an ED_<50> value of 1.2×10^<-4>M, a value which was comparable to that of adenosine. AMP-induced relaxation was also potentiated by EHNA treatment. α, β-methylene adenosine diphosphate (AOPCP), an ecto-5'-nucleotidase inhibitor, caused no effect on adenosine-induced relaxation, while it inhibited AMP-induced relaxation around 80%. The concentration of AOPCP used in this experiment. inhibited AMP degaradation in the aorta by 50 to 85%. These results suggest that AMP-induced relaxation is due to adenosine produced through ecto-5'-nucleotidase pathway and the relaxation potency of AMP itself is very weak.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"129368","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Imai, Hirohisa"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"今井, 裕久"}],"nameIdentifiers":[{"nameIdentifier":"129367","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-16"}],"displaytype":"detail","filename":"106(03)_188-195.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"106(03)_188-195.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/21093/files/106(03)_188-195.pdf"},"version_id":"388623d2-15bd-4dd3-b187-1f505b7a4e5f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"guinea pig thoracic aorta","subitem_subject_scheme":"Other"},{"subitem_subject":"AMP","subitem_subject_scheme":"Other"},{"subitem_subject":"adenosine","subitem_subject_scheme":"Other"},{"subitem_subject":"5'-nucleotidase","subitem_subject_scheme":"Other"},{"subitem_subject":"AOPCP","subitem_subject_scheme":"Other"},{"subitem_subject":"モルモット胸部大動脈","subitem_subject_scheme":"Other"},{"subitem_subject":"アデノシン","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Adenosine 5'-monophosphate(AMP)のモルモット摘出胸部大動脈弛緩作用について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Adenosine 5'-monophosphate(AMP)のモルモット摘出胸部大動脈弛緩作用について"},{"subitem_title":"Adenosine 5'-monophosphate(AMP)のモルモット摘出胸部大動脈弛緩作用について","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1176"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-03-14"},"publish_date":"2016-03-14","publish_status":"0","recid":"21093","relation_version_is_last":true,"title":["Adenosine 5'-monophosphate(AMP)のモルモット摘出胸部大動脈弛緩作用について"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:51:41.655385+00:00"}