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大腸癌に対するUFT投与後の組織内5-FU濃度とThymidylate Synthase阻害率および腫瘍組織変性に関する研究
http://hdl.handle.net/10191/39686
http://hdl.handle.net/10191/39686239a5688-cd24-4c63-b184-739ea177cfae
名前 / ファイル | ライセンス | アクション |
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106(05)_424-435.pdf (2.7 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-03-15 | |||||
タイトル | ||||||
タイトル | 大腸癌に対するUFT投与後の組織内5-FU濃度とThymidylate Synthase阻害率および腫瘍組織変性に関する研究 | |||||
タイトル | ||||||
タイトル | 大腸癌に対するUFT投与後の組織内5-FU濃度とThymidylate Synthase阻害率および腫瘍組織変性に関する研究 | |||||
言語 | en | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | colorectal carcinoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 5-FU | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | thymidylate synthase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | degeneration of neoplastic tissue | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 大腸癌 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 5-フルオロウラシル | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | チミジル酸合成酵素 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 腫瘍組織変性 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | A Study on Concentration of 5-FU and Thymidylate Synthase Inhibition Rate in Neoplastic and Non-Neoplastic Tissues Related to Degeneration of Colorectal Neoplastic Tissue | |||||
著者 |
牛山, 信
× 牛山, 信 |
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著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 128770 | |||||
姓名 | Ushiyama, Makoto | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | UFT, a derivative of 5-FU, was administered orally to patients with colorectal carcinoma before surgery. materials for analysis consisted of neoplastic and non-neoplastic tissues from colorectal tract, lymph nodes involved and uninvolved, and metastatic tissue from the liver. Concentration of 5-FU was 0.148±0.014μg/g in neoplastic tissue, sufficient for clinical effect (0.05μg/g). There was no significant difference of the TS inhibition rate (averaging 42.5%) among the tissues abovementioned. There was a correlation between the concentration of 5-FU in the TS inhibition rate in all cases, but, no correlation in sex, stages, and lacation and histologic types of the tumors. In patients with age under 75 years, however, there was a correlation (p<0.05) between the two previously described. To evaluate degeneration of neoplastic tissue, effects were determined in accordance with The General Rules for the Gastric Cancer Study. Eight of 47 evaluated by histology indicated histologic degeneration Grade la ; 2 of them also showed degeneration in lymph nodes involved. The TS inhibition rate was 41.6±2.2% (n=39) in group of negative degeneration and 55.2±2.1% (n=8) in group of positive degeneration ; it was significantly high in the latter group showing over 50% in all but one case. It was considered that there was a possibility of histologic degeneration in neoplastic tissue in patients with a high TS inhibition rate over 50%. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 106, 号 5, p. 424-435, 発行日 1992-05 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |