{"created":"2021-03-01T06:25:58.902945+00:00","id":20976,"links":{},"metadata":{"_buckets":{"deposit":"e1b741f5-00a9-4580-a2db-a05e537cf772"},"_deposit":{"id":"20976","owners":[],"pid":{"revision_id":0,"type":"depid","value":"20976"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00020976","sets":["453:456","471:537:538:1174"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"A Study on Concentration of 5-FU and Thymidylate Synthase Inhibition Rate in Neoplastic and Non-Neoplastic Tissues Related to Degeneration of Colorectal Neoplastic Tissue"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1992-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"435","bibliographicPageStart":"424","bibliographicVolumeNumber":"106","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"UFT, a derivative of 5-FU, was administered orally to patients with colorectal carcinoma before surgery. materials for analysis consisted of neoplastic and non-neoplastic tissues from colorectal tract, lymph nodes involved and uninvolved, and metastatic tissue from the liver. Concentration of 5-FU was 0.148±0.014μg/g in neoplastic tissue, sufficient for clinical effect (0.05μg/g). There was no significant difference of the TS inhibition rate (averaging 42.5%) among the tissues abovementioned. There was a correlation between the concentration of 5-FU in the TS inhibition rate in all cases, but, no correlation in sex, stages, and lacation and histologic types of the tumors. In patients with age under 75 years, however, there was a correlation (p<0.05) between the two previously described. To evaluate degeneration of neoplastic tissue, effects were determined in accordance with The General Rules for the Gastric Cancer Study. Eight of 47 evaluated by histology indicated histologic degeneration Grade la ; 2 of them also showed degeneration in lymph nodes involved. The TS inhibition rate was 41.6±2.2% (n=39) in group of negative degeneration and 55.2±2.1% (n=8) in group of positive degeneration ; it was significantly high in the latter group showing over 50% in all but one case. It was considered that there was a possibility of histologic degeneration in neoplastic tissue in patients with a high TS inhibition rate over 50%.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"128770","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ushiyama, Makoto"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"牛山, 信"}],"nameIdentifiers":[{"nameIdentifier":"128769","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-16"}],"displaytype":"detail","filename":"106(05)_424-435.pdf","filesize":[{"value":"2.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"106(05)_424-435.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/20976/files/106(05)_424-435.pdf"},"version_id":"7fa25b7d-2cfe-49bd-a674-08bc9babdb2b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"colorectal carcinoma","subitem_subject_scheme":"Other"},{"subitem_subject":"5-FU","subitem_subject_scheme":"Other"},{"subitem_subject":"thymidylate synthase","subitem_subject_scheme":"Other"},{"subitem_subject":"degeneration of neoplastic tissue","subitem_subject_scheme":"Other"},{"subitem_subject":"大腸癌","subitem_subject_scheme":"Other"},{"subitem_subject":"5-フルオロウラシル","subitem_subject_scheme":"Other"},{"subitem_subject":"チミジル酸合成酵素","subitem_subject_scheme":"Other"},{"subitem_subject":"腫瘍組織変性","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"大腸癌に対するUFT投与後の組織内5-FU濃度とThymidylate Synthase阻害率および腫瘍組織変性に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"大腸癌に対するUFT投与後の組織内5-FU濃度とThymidylate Synthase阻害率および腫瘍組織変性に関する研究"},{"subitem_title":"大腸癌に対するUFT投与後の組織内5-FU濃度とThymidylate Synthase阻害率および腫瘍組織変性に関する研究","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1174"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-03-15"},"publish_date":"2016-03-15","publish_status":"0","recid":"20976","relation_version_is_last":true,"title":["大腸癌に対するUFT投与後の組織内5-FU濃度とThymidylate Synthase阻害率および腫瘍組織変性に関する研究"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:51:37.869395+00:00"}