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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第106巻第5号

グリオーマに対するACNU・放射線併用療法の基礎的研究 : ACNUの細胞周期内進行に及ぼす効果と放射線の併用時期

http://hdl.handle.net/10191/39681
http://hdl.handle.net/10191/39681
7ac91e46-847a-4ee5-b1a5-d24866ec1a56
名前 / ファイル ライセンス アクション
106(05)_405-412.pdf 106(05)_405-412.pdf (1.5 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-03-15
タイトル
タイトル グリオーマに対するACNU・放射線併用療法の基礎的研究 : ACNUの細胞周期内進行に及ぼす効果と放射線の併用時期
タイトル
言語 en
タイトル グリオーマに対するACNU・放射線併用療法の基礎的研究 : ACNUの細胞周期内進行に及ぼす効果と放射線の併用時期
言語
言語 jpn
キーワード
主題Scheme Other
主題 cell cycle perturbation
キーワード
主題Scheme Other
主題 flow cytometry
キーワード
主題Scheme Other
主題 ACNU
キーワード
主題Scheme Other
主題 C_6 cells
キーワード
主題Scheme Other
主題 chemo-radiotherapy
キーワード
主題Scheme Other
主題 細胞周期移行阻害
キーワード
主題Scheme Other
主題 フローサイトメトリー
キーワード
主題Scheme Other
主題 C_6細胞
キーワード
主題Scheme Other
主題 化学放射線療法
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Role of ACNU : induced Cell Cycle Perturbations in Enhancing Effect on Radiotherapy
著者 村上, 直人

× 村上, 直人

WEKO 128765

村上, 直人

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著者別名
識別子 128766
識別子Scheme WEKO
姓名 Murakami, Naoto
抄録
内容記述タイプ Abstract
内容記述 The cell cycle perturbations induced by ACNU and their role in enhancing effect on radiotherapy were studied using C_6 rat glioma cells. The cell cycle perturbations were analyzed with flow cytometry from 3 to 72 hours after ACNU treatment. The major effect of ACNU on cell cycle progression was G_2M accumulation. Alteration of the DNA histograms after exposure to ACNU (10, 25μg/ml) showed common features ; the G_2M accumulation increased to a maximum at 24hr, remained by 30hr, then decreased gradually. From these analyses, the temporal course of accumulation to G_2M phase of cell cycle in the presence of ACNU (10, 25μg/ml) was demonstrated. To examine whether the G_2M accumulation induced by ACNU is responsible for the potentiation of irradiation, the following study was performed. Cells were irradiated (6 Gy) at various time intervals after ACNU treatment (25ng/ml, 1hr), and post-treatment survival was assessed by colony forming assay. All survival values obtained from the combination treatment schedules were normalized for the ACNU cell kill and then compared with the survival value obtained after irradiation alone. It appeared that combined treatment had a similar synergistic effect in all combination schedules. From these studies, it was concluded that the G_2M accumulation induced by ACNU would not be the partial synchronization as the mechanism responsible for the potentiation of irradiation.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 106, 号 5, p. 405-412, 発行日 1992-05
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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