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Experiments were carried out in the presence of verapamil (Ver) 10^\u003c-5\u003eM to avoid the contribution of Ca^\u003c2+\u003e influx via voltage dependent Ca^\u003c2+\u003e channel (VDC). The contraction induced by phenylephrine (Phe) 10^\u003c-6\u003eM under this condition depended on the presence of Ca^\u003c2+\u003e in the extracellular space, suggesting that the Ca^\u003c2+\u003e influx from the extracellular space was indispensable for elicitation of contraction. The contraction was also dependent on the concentration of Na^+ in the extracellular space except for Na^+-free condition. Tonic component of the contraction constitued a plateau with low Na^+ concentrations, but showed a gradual increase with time with higher Na^+ concentrations. Dichlorobenzamil, a Na^+-Ca^\u003c2+\u003e exchange system inhibitor, attenuated this contraction. Noradrenaline (Nor) 10^\u003c-6\u003eM also showed an extracellular Na^+ dependent contraction, as Phe did. However, in the absence of Na^+, almost equal contraction to those observed in the presence of normal concentration of Na^+ was observed, suggesting the contribution of Ca^\u003c2+\u003e release from intracellular Ca^\u003c2+\u003e store. The contraction by Nor as well as by Phe were inhibited by H-7, a C-kinase inhibitor. These results suggest that, when \u03b1_1-adrenoceptor is stimulated, C-kinase is activated through formation of diacylglycerol and increases in Na^+ influx via Na^+-H^+ exchange system results. The accumulated Na^+, in turn, enhances Na^+-Ca^\u003c2+\u003e exchange leading to increases in Ca^\u003c2+\u003e influx.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "128109", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Mito, Motoko"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u6c34\u6238, \u5143\u5b50"}], "nameIdentifiers": [{"nameIdentifier": "128108", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "106(08)_787-795.pdf", "filesize": [{"value": "1.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1300000.0, "url": {"label": "106(08)_787-795.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/20821/files/106(08)_787-795.pdf"}, "version_id": "2419ed9f-2c32-45e6-bca4-6c6887448e4d"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "vascular smooth muscle", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u03b1_1-adrenoceptor", "subitem_subject_scheme": "Other"}, {"subitem_subject": "C-kinase", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Na^+-H^+ exchange", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Na^+-Ca^\u003c2+\u003e exchange", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u8840\u7ba1\u5e73\u6ed1\u7b4b", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u03b1_1-\u53d7\u5bb9\u4f53", "subitem_subject_scheme": "Other"}, {"subitem_subject": "C-\u30ad\u30ca\u30fc\u30bc", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Na^+-H^+\u4ea4\u63db\u6a5f\u69cb", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Na^+-Ca^\u003c2+\u003e\u4ea4\u63db\u6a5f\u69cb", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u4f5c\u52d5\u6027\u03b1_1-\u53d7\u5bb9\u4f53\u523a\u6fc0\u306b\u3088\u308b\u30e9\u30c3\u30c8\u5927\u52d5\u8108\u5e73\u6ed1\u7b4b\u306e\u53ce\u7e2e : \u5916\u6db2Na^+\u6fc3\u5ea6\u4f9d\u5b58\u6027\u306b\u3064\u3044\u3066", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u4f5c\u52d5\u6027\u03b1_1-\u53d7\u5bb9\u4f53\u523a\u6fc0\u306b\u3088\u308b\u30e9\u30c3\u30c8\u5927\u52d5\u8108\u5e73\u6ed1\u7b4b\u306e\u53ce\u7e2e : \u5916\u6db2Na^+\u6fc3\u5ea6\u4f9d\u5b58\u6027\u306b\u3064\u3044\u3066"}, {"subitem_title": "\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u4f5c\u52d5\u6027\u03b1_1-\u53d7\u5bb9\u4f53\u523a\u6fc0\u306b\u3088\u308b\u30e9\u30c3\u30c8\u5927\u52d5\u8108\u5e73\u6ed1\u7b4b\u306e\u53ce\u7e2e : \u5916\u6db2Na^+\u6fc3\u5ea6\u4f9d\u5b58\u6027\u306b\u3064\u3044\u3066", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1171"], "permalink_uri": "http://hdl.handle.net/10191/39897", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2016-03-18"}, "publish_date": "2016-03-18", "publish_status": "0", "recid": "20821", "relation": {}, "relation_version_is_last": true, "title": ["\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u4f5c\u52d5\u6027\u03b1_1-\u53d7\u5bb9\u4f53\u523a\u6fc0\u306b\u3088\u308b\u30e9\u30c3\u30c8\u5927\u52d5\u8108\u5e73\u6ed1\u7b4b\u306e\u53ce\u7e2e : \u5916\u6db2Na^+\u6fc3\u5ea6\u4f9d\u5b58\u6027\u306b\u3064\u3044\u3066"], "weko_shared_id": null}