{"created":"2021-03-01T06:25:48.654234+00:00","id":20821,"links":{},"metadata":{"_buckets":{"deposit":"87990818-9452-4ff4-9edd-3b22a21171d4"},"_deposit":{"id":"20821","owners":[],"pid":{"revision_id":0,"type":"depid","value":"20821"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00020821","sets":["453:456","471:537:538:1171"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"A mechanism of contraction of the rat aortic smooth muscle by α_1-adrenoceptor stimulation : dependency on extracellular Na^+"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1992-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"795","bibliographicPageStart":"787","bibliographicVolumeNumber":"106","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Contraction of rat aortic smooth muscle by α_1-adrenoceptor stimulation was examined in relation to extracellular Na^+ concentration. Experiments were carried out in the presence of verapamil (Ver) 10^<-5>M to avoid the contribution of Ca^<2+> influx via voltage dependent Ca^<2+> channel (VDC). The contraction induced by phenylephrine (Phe) 10^<-6>M under this condition depended on the presence of Ca^<2+> in the extracellular space, suggesting that the Ca^<2+> influx from the extracellular space was indispensable for elicitation of contraction. The contraction was also dependent on the concentration of Na^+ in the extracellular space except for Na^+-free condition. Tonic component of the contraction constitued a plateau with low Na^+ concentrations, but showed a gradual increase with time with higher Na^+ concentrations. Dichlorobenzamil, a Na^+-Ca^<2+> exchange system inhibitor, attenuated this contraction. Noradrenaline (Nor) 10^<-6>M also showed an extracellular Na^+ dependent contraction, as Phe did. However, in the absence of Na^+, almost equal contraction to those observed in the presence of normal concentration of Na^+ was observed, suggesting the contribution of Ca^<2+> release from intracellular Ca^<2+> store. The contraction by Nor as well as by Phe were inhibited by H-7, a C-kinase inhibitor. These results suggest that, when α_1-adrenoceptor is stimulated, C-kinase is activated through formation of diacylglycerol and increases in Na^+ influx via Na^+-H^+ exchange system results. The accumulated Na^+, in turn, enhances Na^+-Ca^<2+> exchange leading to increases in Ca^<2+> influx.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"128109","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Mito, Motoko"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"水戸, 元子"}],"nameIdentifiers":[{"nameIdentifier":"128108","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-16"}],"displaytype":"detail","filename":"106(08)_787-795.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"106(08)_787-795.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/20821/files/106(08)_787-795.pdf"},"version_id":"2419ed9f-2c32-45e6-bca4-6c6887448e4d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"vascular smooth muscle","subitem_subject_scheme":"Other"},{"subitem_subject":"α_1-adrenoceptor","subitem_subject_scheme":"Other"},{"subitem_subject":"C-kinase","subitem_subject_scheme":"Other"},{"subitem_subject":"Na^+-H^+ exchange","subitem_subject_scheme":"Other"},{"subitem_subject":"Na^+-Ca^<2+> exchange","subitem_subject_scheme":"Other"},{"subitem_subject":"血管平滑筋","subitem_subject_scheme":"Other"},{"subitem_subject":"α_1-受容体","subitem_subject_scheme":"Other"},{"subitem_subject":"C-キナーゼ","subitem_subject_scheme":"Other"},{"subitem_subject":"Na^+-H^+交換機構","subitem_subject_scheme":"Other"},{"subitem_subject":"Na^+-Ca^<2+>交換機構","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"アドレナリン作動性α_1-受容体刺激によるラット大動脈平滑筋の収縮 : 外液Na^+濃度依存性について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アドレナリン作動性α_1-受容体刺激によるラット大動脈平滑筋の収縮 : 外液Na^+濃度依存性について"},{"subitem_title":"アドレナリン作動性α_1-受容体刺激によるラット大動脈平滑筋の収縮 : 外液Na^+濃度依存性について","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1171"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-03-18"},"publish_date":"2016-03-18","publish_status":"0","recid":"20821","relation_version_is_last":true,"title":["アドレナリン作動性α_1-受容体刺激によるラット大動脈平滑筋の収縮 : 外液Na^+濃度依存性について"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:51:30.321654+00:00"}