{"_buckets": {"deposit": "ed7d7891-16d3-4fb9-aa3f-0961190b6a4d"}, "_deposit": {"id": "20819", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "20819"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00020819", "sets": ["456", "1171"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "The effects of Pco_2 on endothelin-1 contractions in isolated guinea pig tracheae"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1992-08", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "8", "bibliographicPageEnd": "777", "bibliographicPageStart": "773", "bibliographicVolumeNumber": "106", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Contractile responses of isolated guinea pig tracheae to endothelin-1 (ET-1), a vasoactive substance recently isolated from endothelium, were studied at extremely low Pco_2 (15±1mmHg, n=32), moderately low Pco_2 (28±1mmHg, n=23), normal Pco_2 (38±1mmHg, n=57) and high Pco_2 (92±1mmHg, n=32). The minimum concentration of ET-1 (10^\u003c-10\u003eM) needed to induce contractions was lower than that of acetylcholine (10^\u003c-7\u003eM) and histamine (10^\u003c-7\u003eM) at normal Pco_2. Pco_2 did not affect acetylcholine- or histamine-induced contractions. In contrast, extremely low and moderately low Pco_2 attenuated the contractions induced by ET-1, but high Pco_2 potentiated those induced by a high concentration of ET-1. In the presence of aspirin (10^\u003c-4\u003eM) and indomethacin (3×10^\u003c-6\u003eM), the responses to endothelin-1 were not influenced by extremely low Pco_2. The results suggest that cyclooxygenase-related eicosanoids are involved in the effects of Pco_2 on ET-1-induced contractions.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "128105", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Tsukui, Atsushi"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "津久井, 淳"}], "nameIdentifiers": [{"nameIdentifier": "128104", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "106(08)_773-777.pdf", "filesize": [{"value": "828.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 828600.0, "url": {"label": "106(08)_773-777.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/20819/files/106(08)_773-777.pdf"}, "version_id": "c7578aee-adb8-4c42-8fbb-21bc0f25a8e4"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Tracheal smooth muscle", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Carbon dioxide", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Endothelin-1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Eicosanoids", "subitem_subject_scheme": "Other"}, {"subitem_subject": "気管平滑筋", "subitem_subject_scheme": "Other"}, {"subitem_subject": "炭酸ガス分圧", "subitem_subject_scheme": "Other"}, {"subitem_subject": "エンドセリン-1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "エイコサノイド", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "モルモット摘出気管のエンドセリン-1収縮反応における炭酸ガス分圧の影響", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "モルモット摘出気管のエンドセリン-1収縮反応における炭酸ガス分圧の影響"}, {"subitem_title": "モルモット摘出気管のエンドセリン-1収縮反応における炭酸ガス分圧の影響", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1171"], "permalink_uri": "http://hdl.handle.net/10191/39901", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-03-18"}, "publish_date": "2016-03-18", "publish_status": "0", "recid": "20819", "relation": {}, "relation_version_is_last": true, "title": ["モルモット摘出気管のエンドセリン-1収縮反応における炭酸ガス分圧の影響"], "weko_shared_id": null}