{"created":"2021-03-01T06:25:48.524305+00:00","id":20819,"links":{},"metadata":{"_buckets":{"deposit":"ed7d7891-16d3-4fb9-aa3f-0961190b6a4d"},"_deposit":{"id":"20819","owners":[],"pid":{"revision_id":0,"type":"depid","value":"20819"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00020819","sets":["453:456","471:537:538:1171"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The effects of Pco_2 on endothelin-1 contractions in isolated guinea pig tracheae"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1992-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"777","bibliographicPageStart":"773","bibliographicVolumeNumber":"106","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Contractile responses of isolated guinea pig tracheae to endothelin-1 (ET-1), a vasoactive substance recently isolated from endothelium, were studied at extremely low Pco_2 (15±1mmHg, n=32), moderately low Pco_2 (28±1mmHg, n=23), normal Pco_2 (38±1mmHg, n=57) and high Pco_2 (92±1mmHg, n=32). The minimum concentration of ET-1 (10^<-10>M) needed to induce contractions was lower than that of acetylcholine (10^<-7>M) and histamine (10^<-7>M) at normal Pco_2. Pco_2 did not affect acetylcholine- or histamine-induced contractions. In contrast, extremely low and moderately low Pco_2 attenuated the contractions induced by ET-1, but high Pco_2 potentiated those induced by a high concentration of ET-1. In the presence of aspirin (10^<-4>M) and indomethacin (3×10^<-6>M), the responses to endothelin-1 were not influenced by extremely low Pco_2. The results suggest that cyclooxygenase-related eicosanoids are involved in the effects of Pco_2 on ET-1-induced contractions.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"128105","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tsukui, Atsushi"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"津久井, 淳"}],"nameIdentifiers":[{"nameIdentifier":"128104","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-16"}],"displaytype":"detail","filename":"106(08)_773-777.pdf","filesize":[{"value":"828.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"106(08)_773-777.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/20819/files/106(08)_773-777.pdf"},"version_id":"c7578aee-adb8-4c42-8fbb-21bc0f25a8e4"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Tracheal smooth muscle","subitem_subject_scheme":"Other"},{"subitem_subject":"Carbon dioxide","subitem_subject_scheme":"Other"},{"subitem_subject":"Endothelin-1","subitem_subject_scheme":"Other"},{"subitem_subject":"Eicosanoids","subitem_subject_scheme":"Other"},{"subitem_subject":"気管平滑筋","subitem_subject_scheme":"Other"},{"subitem_subject":"炭酸ガス分圧","subitem_subject_scheme":"Other"},{"subitem_subject":"エンドセリン-1","subitem_subject_scheme":"Other"},{"subitem_subject":"エイコサノイド","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"モルモット摘出気管のエンドセリン-1収縮反応における炭酸ガス分圧の影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"モルモット摘出気管のエンドセリン-1収縮反応における炭酸ガス分圧の影響"},{"subitem_title":"モルモット摘出気管のエンドセリン-1収縮反応における炭酸ガス分圧の影響","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1171"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-03-18"},"publish_date":"2016-03-18","publish_status":"0","recid":"20819","relation_version_is_last":true,"title":["モルモット摘出気管のエンドセリン-1収縮反応における炭酸ガス分圧の影響"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:51:31.064879+00:00"}