{"created":"2021-03-01T06:25:48.524305+00:00","id":20819,"links":{},"metadata":{"_buckets":{"deposit":"ed7d7891-16d3-4fb9-aa3f-0961190b6a4d"},"_deposit":{"id":"20819","owners":[],"pid":{"revision_id":0,"type":"depid","value":"20819"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00020819"},"item_7_alternative_title_1":{"attribute_name":"\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb","attribute_value_mlt":[{"subitem_alternative_title":"The effects of Pco_2 on endothelin-1 contractions in isolated guinea pig tracheae"}]},"item_7_biblio_info_6":{"attribute_name":"\u66f8\u8a8c\u60c5\u5831","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1992-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"777","bibliographicPageStart":"773","bibliographicVolumeNumber":"106","bibliographic_titles":[{"bibliographic_title":"\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"},{"bibliographic_title":"\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"\u6284\u9332","attribute_value_mlt":[{"subitem_description":"Contractile responses of isolated guinea pig tracheae to endothelin-1 (ET-1), a vasoactive substance recently isolated from endothelium, were studied at extremely low Pco_2 (15\u00b11mmHg, n=32), moderately low Pco_2 (28\u00b11mmHg, n=23), normal Pco_2 (38\u00b11mmHg, n=57) and high Pco_2 (92\u00b11mmHg, n=32). The minimum concentration of ET-1 (10^<-10>M) needed to induce contractions was lower than that of acetylcholine (10^<-7>M) and histamine (10^<-7>M) at normal Pco_2. Pco_2 did not affect acetylcholine- or histamine-induced contractions. In contrast, extremely low and moderately low Pco_2 attenuated the contractions induced by ET-1, but high Pco_2 potentiated those induced by a high concentration of ET-1. In the presence of aspirin (10^<-4>M) and indomethacin (3\u00d710^<-6>M), the responses to endothelin-1 were not influenced by extremely low Pco_2. The results suggest that cyclooxygenase-related eicosanoids are involved in the effects of Pco_2 on ET-1-induced contractions.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"\u8457\u8005\u5225\u540d","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"128105","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tsukui, Atsushi"}]}]},"item_7_publisher_7":{"attribute_name":"\u51fa\u7248\u8005","attribute_value_mlt":[{"subitem_publisher":"\u65b0\u6f5f\u533b\u5b66\u4f1a"}]},"item_7_select_19":{"attribute_name":"\u8457\u8005\u7248\u30d5\u30e9\u30b0","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"\u8457\u8005","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"\u6d25\u4e45\u4e95, \u6df3"}],"nameIdentifiers":[{"nameIdentifier":"128104","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"\u30d5\u30a1\u30a4\u30eb\u60c5\u5831","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-16"}],"displaytype":"detail","filename":"106(08)_773-777.pdf","filesize":[{"value":"828.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"106(08)_773-777.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/20819/files/106(08)_773-777.pdf"},"version_id":"c7578aee-adb8-4c42-8fbb-21bc0f25a8e4"}]},"item_keyword":{"attribute_name":"\u30ad\u30fc\u30ef\u30fc\u30c9","attribute_value_mlt":[{"subitem_subject":"Tracheal smooth muscle","subitem_subject_scheme":"Other"},{"subitem_subject":"Carbon dioxide","subitem_subject_scheme":"Other"},{"subitem_subject":"Endothelin-1","subitem_subject_scheme":"Other"},{"subitem_subject":"Eicosanoids","subitem_subject_scheme":"Other"},{"subitem_subject":"\u6c17\u7ba1\u5e73\u6ed1\u7b4b","subitem_subject_scheme":"Other"},{"subitem_subject":"\u70ad\u9178\u30ac\u30b9\u5206\u5727","subitem_subject_scheme":"Other"},{"subitem_subject":"\u30a8\u30f3\u30c9\u30bb\u30ea\u30f3-1","subitem_subject_scheme":"Other"},{"subitem_subject":"\u30a8\u30a4\u30b3\u30b5\u30ce\u30a4\u30c9","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"\u8a00\u8a9e","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"\u8cc7\u6e90\u30bf\u30a4\u30d7","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"\u30e2\u30eb\u30e2\u30c3\u30c8\u6458\u51fa\u6c17\u7ba1\u306e\u30a8\u30f3\u30c9\u30bb\u30ea\u30f3-1\u53ce\u7e2e\u53cd\u5fdc\u306b\u304a\u3051\u308b\u70ad\u9178\u30ac\u30b9\u5206\u5727\u306e\u5f71\u97ff","item_titles":{"attribute_name":"\u30bf\u30a4\u30c8\u30eb","attribute_value_mlt":[{"subitem_title":"\u30e2\u30eb\u30e2\u30c3\u30c8\u6458\u51fa\u6c17\u7ba1\u306e\u30a8\u30f3\u30c9\u30bb\u30ea\u30f3-1\u53ce\u7e2e\u53cd\u5fdc\u306b\u304a\u3051\u308b\u70ad\u9178\u30ac\u30b9\u5206\u5727\u306e\u5f71\u97ff"},{"subitem_title":"\u30e2\u30eb\u30e2\u30c3\u30c8\u6458\u51fa\u6c17\u7ba1\u306e\u30a8\u30f3\u30c9\u30bb\u30ea\u30f3-1\u53ce\u7e2e\u53cd\u5fdc\u306b\u304a\u3051\u308b\u70ad\u9178\u30ac\u30b9\u5206\u5727\u306e\u5f71\u97ff","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["453/456","471/537/538/1171"],"pubdate":{"attribute_name":"\u516c\u958b\u65e5","attribute_value":"2016-03-18"},"publish_date":"2016-03-18","publish_status":"0","recid":"20819","relation_version_is_last":true,"title":["\u30e2\u30eb\u30e2\u30c3\u30c8\u6458\u51fa\u6c17\u7ba1\u306e\u30a8\u30f3\u30c9\u30bb\u30ea\u30f3-1\u53ce\u7e2e\u53cd\u5fdc\u306b\u304a\u3051\u308b\u70ad\u9178\u30ac\u30b9\u5206\u5727\u306e\u5f71\u97ff"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2021-03-01T13:56:02.990227+00:00"}