{"_buckets": {"deposit": "b360daf5-a03b-4741-8272-c84d107deeaa"}, "_deposit": {"id": "20750", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "20750"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00020750", "sets": ["456", "1170"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "The Effect of High Pco_2 on Agonists-Induced Contraction in Rat Aorta :  Influence of Endothelium"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1992-09", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "9", "bibliographicPageEnd": "843", "bibliographicPageStart": "836", "bibliographicVolumeNumber": "106", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "It has been well known that carbon dioxide (CO_2) has direct inhibitory effects on vascular smooth muscle and induces vasodilation in patients with CO_2 accumulation. However little information is available how CO_2 and endothelium modify the vascular tone induced by various agonists. Thus, I studied effects of high Pco_2 (pH=6.99, Pco_2=91±1mmHg, n=58) on the contractile responses of endothelium-intact and rubbed rat aorta to phenylephrine, potassium chloride (KCl) and human-porcine endothelin-1 (ET-1). High Pco_2 shifted the response of endothelium-intact preparations to phenylephrine to the right with attenuation of maximal response, whereas the pH matched acidotic solution with normal Pco_2 (pH=6.99, Pco_2=38±0 mmHg) shifted that to phenylephrine to the right without changing maximal contraction. The response of endothelium-intact preparations to KCl and ET-1 was not influenced by high Pco_2 and the pH matched acidotic solution with normal Pco_2. In endothelium-rubbed preparation, both high Pco_2 and the pH matched acidotic solution shifted the response to phenylephrine to the right without altering the maximal contraction. The response to KCl of endothelium-rubbed preparation was attenuated by high Pco2, while that to KCl was not influenced by the pH matched acidotic solution. The response to ET-1 of endothelium-rubbed preparation was not altered by high Pco_2. In the presence of cyclooxygenase inhibitors, indomethacin and aspirin, high Pco_2 attenuated the response of endothelium-intact preparations to KCl. The contractile responses of endothelium-intact and rubbed preparations to ET-1 were not influenced by high Pco_2. The findings suggest that the endothelial modulations of the effect of high Pco_2 on vascular smooth muscle contraction are different depending on the agonists. It appears that cyclooxygenase related eicosanoid(s) may be involved in the effects of high Pco_2 on the responses of endothelium-intact preparations to KCl.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "127769", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Taga, Kiichiro"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "多賀, 紀一郎"}], "nameIdentifiers": [{"nameIdentifier": "127768", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "106(09)_836-843.pdf", "filesize": [{"value": "1.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1400000.0, "url": {"label": "106(09)_836-843.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/20750/files/106(09)_836-843.pdf"}, "version_id": "8fed6e97-fbec-4470-9e4a-ee9cda977979"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "carbon dioxide", "subitem_subject_scheme": "Other"}, {"subitem_subject": "eicosanoid", "subitem_subject_scheme": "Other"}, {"subitem_subject": "endothelin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "endothelium", "subitem_subject_scheme": "Other"}, {"subitem_subject": "phenylephrine", "subitem_subject_scheme": "Other"}, {"subitem_subject": "potassium chloride", "subitem_subject_scheme": "Other"}, {"subitem_subject": "rat aorta", "subitem_subject_scheme": "Other"}, {"subitem_subject": "二酸化炭素", "subitem_subject_scheme": "Other"}, {"subitem_subject": "エイコサノイド", "subitem_subject_scheme": "Other"}, {"subitem_subject": "エンドセリン", "subitem_subject_scheme": "Other"}, {"subitem_subject": "血管内皮", "subitem_subject_scheme": "Other"}, {"subitem_subject": "フェニレフリン", "subitem_subject_scheme": "Other"}, {"subitem_subject": "KCl", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ラット大動脈", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "高炭酸ガスのラット大動脈収縮に及ぼす影響 : 血管内皮の役割", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "高炭酸ガスのラット大動脈収縮に及ぼす影響 : 血管内皮の役割"}, {"subitem_title": "高炭酸ガスのラット大動脈収縮に及ぼす影響 : 血管内皮の役割", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1170"], "permalink_uri": "http://hdl.handle.net/10191/39955", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-03-18"}, "publish_date": "2016-03-18", "publish_status": "0", "recid": "20750", "relation": {}, "relation_version_is_last": true, "title": ["高炭酸ガスのラット大動脈収縮に及ぼす影響 : 血管内皮の役割"], "weko_shared_id": null}