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高炭酸ガスのラット大動脈収縮に及ぼす影響 : 血管内皮の役割
http://hdl.handle.net/10191/39955
http://hdl.handle.net/10191/39955aef56b12-858c-4cab-bcfa-3a5ff6aaafa9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
106(09)_836-843.pdf (1.4 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-03-18 | |||||
| タイトル | ||||||
| タイトル | 高炭酸ガスのラット大動脈収縮に及ぼす影響 : 血管内皮の役割 | |||||
| タイトル | ||||||
| タイトル | 高炭酸ガスのラット大動脈収縮に及ぼす影響 : 血管内皮の役割 | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | carbon dioxide | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | eicosanoid | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | endothelin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | endothelium | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | phenylephrine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | potassium chloride | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | rat aorta | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 二酸化炭素 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | エイコサノイド | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | エンドセリン | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 血管内皮 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | フェニレフリン | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | KCl | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ラット大動脈 | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| その他のタイトル | ||||||
| その他のタイトル | The Effect of High Pco_2 on Agonists-Induced Contraction in Rat Aorta : Influence of Endothelium | |||||
| 著者 |
多賀, 紀一郎
× 多賀, 紀一郎 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 127769 | |||||
| 姓名 | Taga, Kiichiro | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | It has been well known that carbon dioxide (CO_2) has direct inhibitory effects on vascular smooth muscle and induces vasodilation in patients with CO_2 accumulation. However little information is available how CO_2 and endothelium modify the vascular tone induced by various agonists. Thus, I studied effects of high Pco_2 (pH=6.99, Pco_2=91±1mmHg, n=58) on the contractile responses of endothelium-intact and rubbed rat aorta to phenylephrine, potassium chloride (KCl) and human-porcine endothelin-1 (ET-1). High Pco_2 shifted the response of endothelium-intact preparations to phenylephrine to the right with attenuation of maximal response, whereas the pH matched acidotic solution with normal Pco_2 (pH=6.99, Pco_2=38±0 mmHg) shifted that to phenylephrine to the right without changing maximal contraction. The response of endothelium-intact preparations to KCl and ET-1 was not influenced by high Pco_2 and the pH matched acidotic solution with normal Pco_2. In endothelium-rubbed preparation, both high Pco_2 and the pH matched acidotic solution shifted the response to phenylephrine to the right without altering the maximal contraction. The response to KCl of endothelium-rubbed preparation was attenuated by high Pco2, while that to KCl was not influenced by the pH matched acidotic solution. The response to ET-1 of endothelium-rubbed preparation was not altered by high Pco_2. In the presence of cyclooxygenase inhibitors, indomethacin and aspirin, high Pco_2 attenuated the response of endothelium-intact preparations to KCl. The contractile responses of endothelium-intact and rubbed preparations to ET-1 were not influenced by high Pco_2. The findings suggest that the endothelial modulations of the effect of high Pco_2 on vascular smooth muscle contraction are different depending on the agonists. It appears that cyclooxygenase related eicosanoid(s) may be involved in the effects of high Pco_2 on the responses of endothelium-intact preparations to KCl. | |||||
| 書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 106, 号 9, p. 836-843, 発行日 1992-09 |
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| 出版者 | ||||||
| 出版者 | 新潟医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00290440 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00182415 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
