{"created":"2021-03-01T06:25:44.054962+00:00","id":20750,"links":{},"metadata":{"_buckets":{"deposit":"b360daf5-a03b-4741-8272-c84d107deeaa"},"_deposit":{"id":"20750","owners":[],"pid":{"revision_id":0,"type":"depid","value":"20750"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00020750","sets":["453:456","471:537:538:1170"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The Effect of High Pco_2 on Agonists-Induced Contraction in Rat Aorta :  Influence of Endothelium"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1992-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"843","bibliographicPageStart":"836","bibliographicVolumeNumber":"106","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"It has been well known that carbon dioxide (CO_2) has direct inhibitory effects on vascular smooth muscle and induces vasodilation in patients with CO_2 accumulation. However little information is available how CO_2 and endothelium modify the vascular tone induced by various agonists. Thus, I studied effects of high Pco_2 (pH=6.99, Pco_2=91±1mmHg, n=58) on the contractile responses of endothelium-intact and rubbed rat aorta to phenylephrine, potassium chloride (KCl) and human-porcine endothelin-1 (ET-1). High Pco_2 shifted the response of endothelium-intact preparations to phenylephrine to the right with attenuation of maximal response, whereas the pH matched acidotic solution with normal Pco_2 (pH=6.99, Pco_2=38±0 mmHg) shifted that to phenylephrine to the right without changing maximal contraction. The response of endothelium-intact preparations to KCl and ET-1 was not influenced by high Pco_2 and the pH matched acidotic solution with normal Pco_2. In endothelium-rubbed preparation, both high Pco_2 and the pH matched acidotic solution shifted the response to phenylephrine to the right without altering the maximal contraction. The response to KCl of endothelium-rubbed preparation was attenuated by high Pco2, while that to KCl was not influenced by the pH matched acidotic solution. The response to ET-1 of endothelium-rubbed preparation was not altered by high Pco_2. In the presence of cyclooxygenase inhibitors, indomethacin and aspirin, high Pco_2 attenuated the response of endothelium-intact preparations to KCl. The contractile responses of endothelium-intact and rubbed preparations to ET-1 were not influenced by high Pco_2. The findings suggest that the endothelial modulations of the effect of high Pco_2 on vascular smooth muscle contraction are different depending on the agonists. It appears that cyclooxygenase related eicosanoid(s) may be involved in the effects of high Pco_2 on the responses of endothelium-intact preparations to KCl.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"127769","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Taga, Kiichiro"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"多賀, 紀一郎"}],"nameIdentifiers":[{"nameIdentifier":"127768","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-16"}],"displaytype":"detail","filename":"106(09)_836-843.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"106(09)_836-843.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/20750/files/106(09)_836-843.pdf"},"version_id":"8fed6e97-fbec-4470-9e4a-ee9cda977979"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"carbon dioxide","subitem_subject_scheme":"Other"},{"subitem_subject":"eicosanoid","subitem_subject_scheme":"Other"},{"subitem_subject":"endothelin","subitem_subject_scheme":"Other"},{"subitem_subject":"endothelium","subitem_subject_scheme":"Other"},{"subitem_subject":"phenylephrine","subitem_subject_scheme":"Other"},{"subitem_subject":"potassium chloride","subitem_subject_scheme":"Other"},{"subitem_subject":"rat aorta","subitem_subject_scheme":"Other"},{"subitem_subject":"二酸化炭素","subitem_subject_scheme":"Other"},{"subitem_subject":"エイコサノイド","subitem_subject_scheme":"Other"},{"subitem_subject":"エンドセリン","subitem_subject_scheme":"Other"},{"subitem_subject":"血管内皮","subitem_subject_scheme":"Other"},{"subitem_subject":"フェニレフリン","subitem_subject_scheme":"Other"},{"subitem_subject":"KCl","subitem_subject_scheme":"Other"},{"subitem_subject":"ラット大動脈","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"高炭酸ガスのラット大動脈収縮に及ぼす影響 : 血管内皮の役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"高炭酸ガスのラット大動脈収縮に及ぼす影響 : 血管内皮の役割"},{"subitem_title":"高炭酸ガスのラット大動脈収縮に及ぼす影響 : 血管内皮の役割","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1170"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-03-18"},"publish_date":"2016-03-18","publish_status":"0","recid":"20750","relation_version_is_last":true,"title":["高炭酸ガスのラット大動脈収縮に及ぼす影響 : 血管内皮の役割"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:51:28.165441+00:00"}