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インドメタシン長期投与ラットにおける胃粘膜防御因子の動態に関する検討
http://hdl.handle.net/10191/40052
http://hdl.handle.net/10191/40052918ec012-64a1-46af-a9e3-7a9ea9d9560b
名前 / ファイル | ライセンス | アクション |
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106(10)_984-989.pdf (1.2 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-03-25 | |||||
タイトル | ||||||
タイトル | インドメタシン長期投与ラットにおける胃粘膜防御因子の動態に関する検討 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | インドメタシン長期投与ラットにおける胃粘膜防御因子の動態に関する検討 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Experimental gastric ulcer in rat | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | indomethacin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gastric mucosal blood flow | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gastric mucosal mucous quantity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gastric mucosal prostaglandin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ラット実験潰瘍 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | インドメタシン | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 胃粘膜血流 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 胃粘膜粘液量 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 胃粘膜プロスタグランジン | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Effect of continuous administration of indomethacin on gastric mucosal barrier in rats. | |||||
著者 |
秋山, 修宏
× 秋山, 修宏 |
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著者別名 | ||||||
識別子 | 127720 | |||||
識別子Scheme | WEKO | |||||
姓名 | Akiyama, Nobuhiro | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | This study was done to clarity the effect of continuous administration of indomethacin (3~5mg/kg/day) on gastric mucosal blood flow, mucosal mucous quantity, and prostaglandin E_2 of the gastric wall in rats. Gastric mucosal blood flow was reduced for 4 weeks by it, but any gastric mucosal lesions were not observed. The mechanism of the reduction of the mucosal blood flow was unknown, but it seems that prostaglandin E_2 had no concern with the reduction of the mucosal blood flow. Mucosal mucus of the corpus was increased, but there were no significant changes in prostaglandin E_2 levels of the gastric wall. It was supposed that gastric mucosa adapted to continuous indomethacin exposure with controlling mucous quantity and reduction of prostaglandin E_2. This mucosal adaptation would prevent gastric mucosal injury of continuous indomethacin exposure. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 106, 号 10, p. 984-989, 発行日 1992-10 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |