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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第106巻第12号

血栓・出血性疾患における血漿11-dehydro-thromboxane B_2濃度の検討 : 固定化抗体カラムによる抽出とラジオイムノアッセイ

http://hdl.handle.net/10191/40239
http://hdl.handle.net/10191/40239
749e1e17-66da-4cb6-bbb7-d07809275ae9
名前 / ファイル ライセンス アクション
106(12)_1138-1145.pdf 106(12)_1138-1145.pdf (1.6 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-03-25
タイトル
タイトル 血栓・出血性疾患における血漿11-dehydro-thromboxane B_2濃度の検討 : 固定化抗体カラムによる抽出とラジオイムノアッセイ
タイトル
言語 en
タイトル 血栓・出血性疾患における血漿11-dehydro-thromboxane B_2濃度の検討 : 固定化抗体カラムによる抽出とラジオイムノアッセイ
言語
言語 jpn
キーワード
主題Scheme Other
主題 11-dehydro-thromboxane B_2
キーワード
主題Scheme Other
主題 immunoaffinity purification
キーワード
主題Scheme Other
主題 essential thrombocythemia
キーワード
主題Scheme Other
主題 idiopathic thrombocytopenic purpura
キーワード
主題Scheme Other
主題 disseminated intravascular coagulation
キーワード
主題Scheme Other
主題 11-デヒドロ-トロンボキサンB_2
キーワード
主題Scheme Other
主題 固定化抗体カラム
キーワード
主題Scheme Other
主題 原発性血小板血症
キーワード
主題Scheme Other
主題 播種性血管内凝固症候群
キーワード
主題Scheme Other
主題 特発性血小板減少性紫斑病
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Plasma 11-dehydro-thromboxane B_2 Levels in Thrombotic and Hemorrhagic Disorders : A New Method by Radioimmunoassay Using Immunoaffinity Purification
著者 樋口, 渉

× 樋口, 渉

WEKO 126657

樋口, 渉

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著者別名
識別子 126658
識別子Scheme WEKO
姓名 Higuchi, Wataru
抄録
内容記述タイプ Abstract
内容記述 11-dehydro-thromboxane B_2 (11-dehydro-TXB_2) has been regarded as a reliable parameter of thromboxane A_2 formation in vivo. The radioimmunoassay of 11-dehydro-TXB_2 with newly developed immunoaffinity purification method was established, and the plasma concentrations in patients with various thrombotic and hemorrhagic disorders were also examined. This new procedure allowed to eliminate unidentified plasma substances effectively. And the radioimmunoassay had a wide detection range (7 to 125 pg, IC_<50>=32.5pg). The plasma levels of 11-dehydro-TXB_2 in healthy subjects (N=30) were 3.15±1.11 (Mean±SD)pg/ml. The age- and sex-related differences were not observed. In patients with idiopathic thrombocytopenic purpura (N=12) and with essential thrombocythemia (N=9), the plasma levels of 11-dehydro-TXB_2 were significantly elevated (7.46±3.99pg/ml and 10.21±9.49pg/ml, respectively) compared with the normal control. Furthermore, in patients with disseminated intravascular coagulation, the values were very high before treatment, but gradually decreased during the treatment coincidentally with decrease in plasma levels of FDP and D-dimer. On the other hand, no statistical differences were found among the levels in the patients with platelet dysfunction (N=11), polycythemia vera (N=3) or deep vein thrombosis (N=4). The measurement of plasma concentration of 11-dehydro-TXB_2 seemed to be a useful tool to detect platelet destruction or platelet activation in patients with thrombotic and hemorrhagic disorders.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 106, 号 12, p. 1138-1145, 発行日 1992-12
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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