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血栓・出血性疾患における血漿11-dehydro-thromboxane B_2濃度の検討 : 固定化抗体カラムによる抽出とラジオイムノアッセイ
http://hdl.handle.net/10191/40239
http://hdl.handle.net/10191/40239749e1e17-66da-4cb6-bbb7-d07809275ae9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
106(12)_1138-1145.pdf (1.6 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-03-25 | |||||
| タイトル | ||||||
| タイトル | 血栓・出血性疾患における血漿11-dehydro-thromboxane B_2濃度の検討 : 固定化抗体カラムによる抽出とラジオイムノアッセイ | |||||
| タイトル | ||||||
| タイトル | 血栓・出血性疾患における血漿11-dehydro-thromboxane B_2濃度の検討 : 固定化抗体カラムによる抽出とラジオイムノアッセイ | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 11-dehydro-thromboxane B_2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | immunoaffinity purification | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | essential thrombocythemia | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | idiopathic thrombocytopenic purpura | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | disseminated intravascular coagulation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 11-デヒドロ-トロンボキサンB_2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 固定化抗体カラム | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 原発性血小板血症 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 播種性血管内凝固症候群 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 特発性血小板減少性紫斑病 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| その他のタイトル | ||||||
| その他のタイトル | Plasma 11-dehydro-thromboxane B_2 Levels in Thrombotic and Hemorrhagic Disorders : A New Method by Radioimmunoassay Using Immunoaffinity Purification | |||||
| 著者 |
樋口, 渉
× 樋口, 渉 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 126658 | |||||
| 姓名 | Higuchi, Wataru | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | 11-dehydro-thromboxane B_2 (11-dehydro-TXB_2) has been regarded as a reliable parameter of thromboxane A_2 formation in vivo. The radioimmunoassay of 11-dehydro-TXB_2 with newly developed immunoaffinity purification method was established, and the plasma concentrations in patients with various thrombotic and hemorrhagic disorders were also examined. This new procedure allowed to eliminate unidentified plasma substances effectively. And the radioimmunoassay had a wide detection range (7 to 125 pg, IC_<50>=32.5pg). The plasma levels of 11-dehydro-TXB_2 in healthy subjects (N=30) were 3.15±1.11 (Mean±SD)pg/ml. The age- and sex-related differences were not observed. In patients with idiopathic thrombocytopenic purpura (N=12) and with essential thrombocythemia (N=9), the plasma levels of 11-dehydro-TXB_2 were significantly elevated (7.46±3.99pg/ml and 10.21±9.49pg/ml, respectively) compared with the normal control. Furthermore, in patients with disseminated intravascular coagulation, the values were very high before treatment, but gradually decreased during the treatment coincidentally with decrease in plasma levels of FDP and D-dimer. On the other hand, no statistical differences were found among the levels in the patients with platelet dysfunction (N=11), polycythemia vera (N=3) or deep vein thrombosis (N=4). The measurement of plasma concentration of 11-dehydro-TXB_2 seemed to be a useful tool to detect platelet destruction or platelet activation in patients with thrombotic and hemorrhagic disorders. | |||||
| 書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 106, 号 12, p. 1138-1145, 発行日 1992-12 |
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| 出版者 | ||||||
| 出版者 | 新潟医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00290440 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00182415 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
