@article{oai:niigata-u.repo.nii.ac.jp:00020523,
 author = {樋口, 渉},
 issue = {12},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Dec},
 note = {11-dehydro-thromboxane B_2 (11-dehydro-TXB_2) has been regarded as a reliable parameter of thromboxane A_2 formation in vivo. The radioimmunoassay of 11-dehydro-TXB_2 with newly developed immunoaffinity purification method was established, and the plasma concentrations in patients with various thrombotic and hemorrhagic disorders were also examined. This new procedure allowed to eliminate unidentified plasma substances effectively. And the radioimmunoassay had a wide detection range (7 to 125 pg, IC_<50>=32.5pg). The plasma levels of 11-dehydro-TXB_2 in healthy subjects (N=30) were 3.15±1.11 (Mean±SD)pg/ml. The age- and sex-related differences were not observed. In patients with idiopathic thrombocytopenic purpura (N=12) and with essential thrombocythemia (N=9), the plasma levels of 11-dehydro-TXB_2 were significantly elevated (7.46±3.99pg/ml and 10.21±9.49pg/ml, respectively) compared with the normal control. Furthermore, in patients with disseminated intravascular coagulation, the values were very high before treatment, but gradually decreased during the treatment coincidentally with decrease in plasma levels of FDP and D-dimer. On the other hand, no statistical differences were found among the levels in the patients with platelet dysfunction (N=11), polycythemia vera (N=3) or deep vein thrombosis (N=4). The measurement of plasma concentration of 11-dehydro-TXB_2 seemed to be a useful tool to detect platelet destruction or platelet activation in patients with thrombotic and hemorrhagic disorders.},
 pages = {1138--1145},
 title = {血栓・出血性疾患における血漿11-dehydro-thromboxane B_2濃度の検討 : 固定化抗体カラムによる抽出とラジオイムノアッセイ},
 volume = {106},
 year = {1992}
}