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  1. 0 資料タイプ別
  2. 01 学術雑誌論文
  1. 250 大学院医歯学総合研究科(医)
  2. 10 学術雑誌論文
  3. 10 査読済論文

Prevention of experimental autoimmune myocarditis by hydrodynamics-based naked Plasmid DNA encoding CTLA4-Ig gene delivery

http://hdl.handle.net/10191/1161
http://hdl.handle.net/10191/1161
bea72513-eb75-4342-8415-578b861fe52f
名前 / ファイル ライセンス アクション
22_0001.pdf 22_0001.pdf (608.6 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2007-04-23
タイトル
タイトル Prevention of experimental autoimmune myocarditis by hydrodynamics-based naked Plasmid DNA encoding CTLA4-Ig gene delivery
言語 en
言語
言語 eng
キーワード
主題Scheme Other
主題 gene therapy
キーワード
主題Scheme Other
主題 dilated cardiomyopathy
キーワード
主題Scheme Other
主題 cytokine
キーワード
主題Scheme Other
主題 pCAGGS
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Abe, Satoru

× Abe, Satoru

WEKO 6595

Abe, Satoru

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Hanawa, Haruo

× Hanawa, Haruo

WEKO 6596

Hanawa, Haruo

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Hayashi, Manabu

× Hayashi, Manabu

WEKO 6597

Hayashi, Manabu

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Yoshida, Tsuyoshi

× Yoshida, Tsuyoshi

WEKO 6598

Yoshida, Tsuyoshi

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Komura, Satoru

× Komura, Satoru

WEKO 6599

Komura, Satoru

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Watanabe, Ritsuo

× Watanabe, Ritsuo

WEKO 6600

Watanabe, Ritsuo

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Lie, Hui

× Lie, Hui

WEKO 6601

Lie, Hui

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Chang, He

× Chang, He

WEKO 6602

Chang, He

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Kato, Kiminori

× Kato, Kiminori

WEKO 6603

Kato, Kiminori

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Kodama, Makoto

× Kodama, Makoto

WEKO 6604

Kodama, Makoto

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Maruyama, Hiroki

× Maruyama, Hiroki

WEKO 6605

Maruyama, Hiroki

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Nakazawa, Mikio

× Nakazawa, Mikio

WEKO 6606

Nakazawa, Mikio

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Miyazaki, Junichi

× Miyazaki, Junichi

WEKO 6607

Miyazaki, Junichi

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Aizawa, Yoshifusa

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WEKO 6608

Aizawa, Yoshifusa

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著者別名
識別子Scheme WEKO
識別子 6609
姓名 塙, 晴雄
抄録
内容記述タイプ Abstract
内容記述 Background: Rat experimental autoimmune myocarditis (EAM) was a T cell-mediated disease, which resembled the giant cell myocarditis seen in humans. Soluble CTLA4 improves some autoimmune diseases by blocking costimulatory signals on T cell. We investigated the effect of hydrodynamics-based naked plasmid DNA encoding CTLA4-immunoglobulin (Ig) gene delivery. Methods and Results: Lewis rats were immunized with cardiac myosin and treated with hydrodynamic-based transfection, namely a rapid tail vein injection of a large volume of pCAGGS encoding CTLA4-Ig chimera solution on Day 0. The vector-derived CTLA4-Ig mRNA expressions were mainly detected in the liver and plasma CTLA4-Ig protein levels were maintained at about 2 μg/ml during the experiment period. On Day 17, the ratio of heart to body weight, the amount of mRNA of atrial natriuretic peptide and the inflammatory areas in CTLA4 group were significantly lower than in the Control group treated with empty plasmid. Maximum rate of intraventricular pressure rise and decline (dp/dt), minimum dp/dt, LVEDP and central venous pressure improved significantly after treatment with CTLA4-Ig. On day 14, expressions of IL-2 in popliteal lymphnodes in the CTLA4-Ig group were significantly lower than in the Control group. Conclusions: Hydrodynamics-based transfection of plasmid encoding CTLA4-Ig chimera dramatically prevented EAM.
書誌情報 journal of cardiac failure
en : journal of cardiac failure

巻 11, 号 7, p. 557-564, 発行日 2005-09
ISSN
収録物識別子タイプ ISSN
収録物識別子 10719164
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11054062
PubMed番号
識別子タイプ PMID
関連識別子 16198253
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1016/j.cardfail.2005.04.005
権利
権利情報 Elsevier Inc.
著者版フラグ
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