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越後白雪茸のマウスでの食事摂取によるNASH進行抑制効果
http://hdl.handle.net/10191/0002000464
http://hdl.handle.net/10191/0002000464437d9154-1551-4e36-8bde-a21365339c78
名前 / ファイル | ライセンス | アクション |
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本文 (3.43MB)
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要旨 (440KB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||
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公開日 | 2022-05-10 | |||||||||
タイトル | ||||||||||
言語 | en | |||||||||
タイトル | Meal ingestion Ceraceomyces tessulatus (Agaricomycetes) protects against NASH in mice | |||||||||
タイトル | ||||||||||
言語 | ja | |||||||||
タイトル | 越後白雪茸のマウスでの食事摂取によるNASH進行抑制効果 | |||||||||
言語 | ||||||||||
言語 | eng | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Functional food | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Lipogenesis | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Non-alcoholic Fatty Liver Disease | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Medicinal mushrooms and fungi | |||||||||
資源タイプ | ||||||||||
資源 | http://purl.org/coar/resource_type/c_db06 | |||||||||
タイプ | doctoral thesis | |||||||||
アクセス権 | ||||||||||
アクセス権 | open access | |||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
その他のタイトル | ||||||||||
その他のタイトル | Effect of Basidiomycetes-X in NASH mice | |||||||||
言語 | en | |||||||||
著者 |
鈴木, 浩史
× 鈴木, 浩史
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抄録 | ||||||||||
内容記述タイプ | Abstract | |||||||||
内容記述 | Non-alcoholic steatohepatitis (NASH) is becoming the most common cause of hepatocellular carcinoma (HCC) in developed countries. Oxidative stress plays a major role in the pathogenesis of NASH due to steatosis and, hence, novel therapeutic approaches might include natural antioxidants. Ceraceomyces tessulatus (strain BDM-X), a novel edible mushroom, possesses potent antioxidant activity. This study aimed to investigate the hepatoprotective effect of BDM-X in a novel NASH-HCC mouse model. To prepare this animal model, 2-day-old C57BL/6J male pups were exposed to low-dose streptozotocin (STZ), and at 4 weeks of age they were randomly divided into 2 groups: the NASH group (NASH) received a high-fat diet (HFD32) up to 14 weeks of age; the BDM-X group (BDM-X) received HFD32 up to age 10 weeks, followed by HFD32 + 20% BDM-X (percentage W/W in the diet) up to age 14 weeks. Mice not treated with STZ fed a normal diet served as a control group. We found that BDM-X improved serum aminotransferase levels as well as histopathological features such as steatosis, inflammatory foci, and pericellular fibrosis in NASH mice. Hepatic protein expression of SREBP-1 and PPARα was significantly increased in NASH mice. BDM-X treatment normalized the expression of both proteins. Our data suggest the BDM-X may protect the liver against lipogenesis in NASH-HCC mice. | |||||||||
言語 | en | |||||||||
内容記述 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | International journal of medicinal mushrooms. 2022, 24(1), 41-52. | |||||||||
言語 | en | |||||||||
DOI | ||||||||||
識別子タイプ | DOI | |||||||||
関連識別子 | https://doi.org/10.1615/intjmedmushrooms.2021041928 | |||||||||
学位名 | ||||||||||
言語 | ja | |||||||||
学位名 | 博士(医学) | |||||||||
学位授与機関 | ||||||||||
学位授与機関識別子Scheme | kakenhi | |||||||||
学位授与機関識別子 | 13101 | |||||||||
言語 | ja | |||||||||
学位授与機関名 | 新潟大学 | |||||||||
言語 | en | |||||||||
学位授与機関名 | Niigata University | |||||||||
学位授与年月日 | ||||||||||
学位授与年月日 | 2021-09-21 | |||||||||
学位授与番号 | ||||||||||
学位授与番号 | 甲第4932号 | |||||||||
学位記番号 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | 新大院博(医)第1022号 | |||||||||
言語 | ja |