{"_buckets": {"deposit": "eea03cc8-582e-43ed-b37d-c5715abfd393"}, "_deposit": {"id": "2000464", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2000464"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:02000464", "sets": ["455", "562"]}, "author_link": [], "control_number": "2000464", "item_6_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Effect of Basidiomycetes-X in NASH mice", "subitem_alternative_title_language": "en"}]}, "item_6_date_granted_51": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2021-09-21"}]}, "item_6_degree_grantor_49": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_language": "ja", "subitem_degreegrantor_name": "新潟大学"}, {"subitem_degreegrantor_language": "en", "subitem_degreegrantor_name": "Niigata University"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "13101", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_6_degree_name_48": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士（医学）", "subitem_degreename_language": "ja"}]}, "item_6_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Non-alcoholic steatohepatitis (NASH) is becoming the most common cause of hepatocellular carcinoma (HCC) in developed countries. Oxidative stress plays a major role in the pathogenesis of NASH due to steatosis and, hence, novel therapeutic approaches might include natural antioxidants. Ceraceomyces tessulatus (strain BDM-X), a novel edible mushroom, possesses potent antioxidant activity. This study aimed to investigate the hepatoprotective effect of BDM-X in a novel NASH-HCC mouse model. To prepare this animal model, 2-day-old C57BL/6J male pups were exposed to low-dose streptozotocin (STZ), and at 4 weeks of age they were randomly divided into 2 groups: the NASH group (NASH) received a high-fat diet (HFD32) up to 14 weeks of age; the BDM-X group (BDM-X) received HFD32 up to age 10 weeks, followed by HFD32 + 20% BDM-X (percentage W/W in the diet) up to age 14 weeks. Mice not treated with STZ fed a normal diet served as a control group. We found that BDM-X improved serum aminotransferase levels as well as histopathological features such as steatosis, inflammatory foci, and pericellular fibrosis in NASH mice. Hepatic protein expression of SREBP-1 and PPARα was significantly increased in NASH mice. BDM-X treatment normalized the expression of both proteins. Our data suggest the BDM-X may protect the liver against lipogenesis in NASH-HCC mice.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_6_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "International journal of medicinal mushrooms. 2022, 24(1), 41-52.", "subitem_description_language": "en", "subitem_description_type": "Other"}]}, "item_6_description_53": {"attribute_name": "学位記番号", "attribute_value_mlt": [{"subitem_description": "新大院博(医)第1022号", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_6_dissertation_number_52": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "甲第4932号"}]}, "item_6_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1615/intjmedmushrooms.2021041928", "subitem_relation_type_select": "DOI"}}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Suzuki, Hiroshi", "creatorNameLang": "en"}, {"creatorName": "鈴木, 浩史", "creatorNameLang": "ja"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"date": [{"dateType": "Available", "dateValue": "2022-05-10"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "r3nmk1022.pdf", "filesize": [{"value": "3.43MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": "3.43MB", "url": {"label": "本文", "objectType": "fulltext", "url": "https://niigata-u.repo.nii.ac.jp/record/2000464/files/r3nmk1022.pdf"}, "version_id": "33547ab7-481f-48af-91f3-ac65a705b564"}, {"date": [{"dateType": "Available", "dateValue": "2022-05-10"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "r3nmk1022_a.pdf", "filesize": [{"value": "440KB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": "440KB", "url": {"label": "要旨", "objectType": "abstract", "url": "https://niigata-u.repo.nii.ac.jp/record/2000464/files/r3nmk1022_a.pdf"}, "version_id": "6ef0bf9b-fffa-432a-85c4-5b3f89b35ba0"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Functional food", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Lipogenesis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Non-alcoholic Fatty Liver Disease", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Medicinal mushrooms and fungi", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Meal ingestion Ceraceomyces tessulatus (Agaricomycetes) protects against NASH in mice", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Meal ingestion Ceraceomyces tessulatus (Agaricomycetes) protects against NASH in mice", "subitem_title_language": "en"}, {"subitem_title": "越後白雪茸のマウスでの食事摂取によるNASH進行抑制効果", "subitem_title_language": "ja"}]}, "item_type_id": "6", "owner": "1", "path": ["455", "562"], "permalink_uri": "http://hdl.handle.net/10191/0002000464", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2022-05-10"}, "publish_date": "2022-05-10", "publish_status": "0", "recid": "2000464", "relation": {}, "relation_version_is_last": true, "title": ["Meal ingestion Ceraceomyces tessulatus (Agaricomycetes) protects against NASH in mice"], "weko_shared_id": -1}