{"created":"2022-05-10T05:52:49.724872+00:00","id":2000464,"links":{},"metadata":{"_buckets":{"deposit":"eea03cc8-582e-43ed-b37d-c5715abfd393"},"_deposit":{"id":"2000464","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2000464"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:02000464","sets":["453:455","471:561:562"]},"author_link":[],"control_number":"2000464","item_6_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Effect of Basidiomycetes-X in NASH mice","subitem_alternative_title_language":"en"}]},"item_6_date_granted_51":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2021-09-21"}]},"item_6_degree_grantor_49":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"新潟大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Niigata University"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"13101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_6_degree_name_48":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_6_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Non-alcoholic steatohepatitis (NASH) is becoming the most common cause of hepatocellular carcinoma (HCC) in developed countries. Oxidative stress plays a major role in the pathogenesis of NASH due to steatosis and, hence, novel therapeutic approaches might include natural antioxidants. Ceraceomyces tessulatus (strain BDM-X), a novel edible mushroom, possesses potent antioxidant activity. This study aimed to investigate the hepatoprotective effect of BDM-X in a novel NASH-HCC mouse model. To prepare this animal model, 2-day-old C57BL/6J male pups were exposed to low-dose streptozotocin (STZ), and at 4 weeks of age they were randomly divided into 2 groups: the NASH group (NASH) received a high-fat diet (HFD32) up to 14 weeks of age; the BDM-X group (BDM-X) received HFD32 up to age 10 weeks, followed by HFD32 + 20% BDM-X (percentage W/W in the diet) up to age 14 weeks. Mice not treated with STZ fed a normal diet served as a control group. We found that BDM-X improved serum aminotransferase levels as well as histopathological features such as steatosis, inflammatory foci, and pericellular fibrosis in NASH mice. Hepatic protein expression of SREBP-1 and PPARα was significantly increased in NASH mice. BDM-X treatment normalized the expression of both proteins. Our data suggest the BDM-X may protect the liver against lipogenesis in NASH-HCC mice.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_6_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"International journal of medicinal mushrooms. 2022, 24(1), 41-52.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_6_description_53":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_description":"新大院博(医)第1022号","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_6_dissertation_number_52":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第4932号"}]},"item_6_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1615/intjmedmushrooms.2021041928","subitem_relation_type_select":"DOI"}}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Suzuki, Hiroshi","creatorNameLang":"en"},{"creatorName":"鈴木, 浩史","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"date":[{"dateType":"Available","dateValue":"2022-05-10"}],"displaytype":"detail","filename":"r3nmk1022.pdf","filesize":[{"value":"3.43MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://niigata-u.repo.nii.ac.jp/record/2000464/files/r3nmk1022.pdf"},"version_id":"33547ab7-481f-48af-91f3-ac65a705b564"},{"date":[{"dateType":"Available","dateValue":"2022-05-10"}],"displaytype":"detail","filename":"r3nmk1022_a.pdf","filesize":[{"value":"440KB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨","objectType":"abstract","url":"https://niigata-u.repo.nii.ac.jp/record/2000464/files/r3nmk1022_a.pdf"},"version_id":"6ef0bf9b-fffa-432a-85c4-5b3f89b35ba0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Functional food","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Lipogenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Non-alcoholic Fatty Liver Disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Medicinal mushrooms and fungi","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Meal ingestion Ceraceomyces tessulatus (Agaricomycetes) protects against NASH in mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Meal ingestion Ceraceomyces tessulatus (Agaricomycetes) protects against NASH in mice","subitem_title_language":"en"},{"subitem_title":"越後白雪茸のマウスでの食事摂取によるNASH進行抑制効果","subitem_title_language":"ja"}]},"item_type_id":"6","owner":"1","path":["455","562"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-05-10"},"publish_date":"2022-05-10","publish_status":"0","recid":"2000464","relation_version_is_last":true,"title":["Meal ingestion Ceraceomyces tessulatus (Agaricomycetes) protects against NASH in mice"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-15T04:16:47.905025+00:00"}