{"_buckets": {"deposit": "0deb1c88-7323-41d9-a2e1-2f3a4375445e"}, "_deposit": {"id": "2000363", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2000363"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:02000363", "sets": ["455", "434"]}, "author_link": [], "item_6_date_granted_51": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2021-03-23"}]}, "item_6_degree_grantor_49": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_language": "ja", "subitem_degreegrantor_name": "新潟大学"}, {"subitem_degreegrantor_language": "en", "subitem_degreegrantor_name": "Niigata University"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "13101", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_6_degree_name_48": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士（歯学）", "subitem_degreename_language": "ja"}]}, "item_6_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Objective: Hypohidrotic ectodermal dysplasia (HED) is a hereditary disorder characterized by abnormal structures and functions of the ectoderm-derived organs, including teeth. HED patients exhibit a variety of dental symptoms, such as hypodontia. Although disruption of the EDA/EDAR/EDARADD/NF-κB pathway is known to be responsible for HED, it remains unclear whether this pathway is involved in the process of enamel formation. Experimental subjects and methods: To address this question, we examined the mice overexpressing Ikkβ (an essential component required for the activation of NF-κB pathway) under the keratin 5 promoter (K5-Ikkβ). Results: Upregulation of the NF-κB pathway was confirmed in the ameloblasts of K5-Ikkβ mice. Premature abrasion was observed in the molars of K5-Ikkβ mice, which was accompanied by less mineralized enamel. However, no significant changes were observed in the enamel thickness and the pattern of enamel rods in K5-Ikkβ mice. Klk4 expression was significantly upregulated in the ameloblasts of K5-Ikkβ mice at the maturation stage, and the expression of its substrate, amelogenin, was remarkably reduced. This suggests that abnormal enamel observed in K5-Ikkβ mice was likely due to the compromised degradation of enamel protein at the maturation stage. Conclusion: Therefore, we could conclude that the overactivation of the NF-κB pathway impairs the process of amelogenesis.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_6_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "Oral Diseases. 2020, 26(7), 1513-1522.", "subitem_description_language": "en", "subitem_description_type": "Other"}]}, "item_6_description_53": {"attribute_name": "学位記番号", "attribute_value_mlt": [{"subitem_description": "新大院博(歯)第475号", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_6_dissertation_number_52": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "甲第4867号"}]}, "item_6_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1111/odi.13384", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "【○!C】 2020 John Wiley \u0026 Sons A/S. Published by John Wiley \u0026 Sons Ltd. All rights reserved", "subitem_rights_language": "en"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yamada, Akane", "creatorNameLang": "en"}, {"creatorName": "山田, 茜", "creatorNameLang": "ja"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"date": [{"dateType": "Available", "dateValue": "2022-04-15"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "r2ndk475.pdf", "filesize": [{"value": "2.17MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": "2.17MB", "url": {"label": "本文", "objectType": "fulltext", "url": "https://niigata-u.repo.nii.ac.jp/record/2000363/files/r2ndk475.pdf"}, "version_id": "d8d4bc55-5a76-4868-a7ed-3bc5a91b289f"}, {"date": [{"dateType": "Available", "dateValue": "2022-04-15"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "r2ndk475_a.pdf", "filesize": [{"value": "140KB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": "140KB", "url": {"label": "要旨", "objectType": "abstract", "url": "https://niigata-u.repo.nii.ac.jp/record/2000363/files/r2ndk475_a.pdf"}, "version_id": "f04f19a2-20e6-4e25-907f-7bed85227614"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "enamel", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "molar", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "NF-κB", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "tooth development", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Overactivation of the NF-κB pathway impairs molar enamel formation", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Overactivation of the NF-κB pathway impairs molar enamel formation", "subitem_title_language": "en"}, {"subitem_title": "NF-κB経路の過剰が臼歯エナメル質形成に異常をもたらす", "subitem_title_language": "ja"}]}, "item_type_id": "6", "owner": "1", "path": ["455", "434"], "permalink_uri": "http://hdl.handle.net/10191/0002000363", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2022-04-15"}, "publish_date": "2022-04-15", "publish_status": "0", "recid": "2000363", "relation": {}, "relation_version_is_last": true, "title": ["Overactivation of the NF-κB pathway impairs molar enamel formation"], "weko_shared_id": -1}