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  1. 260 大学院医歯学総合研究科(歯)
  2. 60 博士学位論文
  3. 10 博士学位論文
  1. 0 資料タイプ別
  2. 02 学位論文

NF-κB経路の過剰が臼歯エナメル質形成に異常をもたらす

http://hdl.handle.net/10191/0002000363
http://hdl.handle.net/10191/0002000363
c6357ae9-b419-4181-a46b-8bf3c59a6249
名前 / ファイル ライセンス アクション
r2ndk475.pdf 本文 (2.17MB)
r2ndk475_a.pdf 要旨 (140KB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2022-04-15
タイトル
言語 en
タイトル Overactivation of the NF-κB pathway impairs molar enamel formation
タイトル
言語 ja
タイトル NF-κB経路の過剰が臼歯エナメル質形成に異常をもたらす
言語
言語 eng
キーワード
言語 en
主題Scheme Other
主題 enamel
キーワード
言語 en
主題Scheme Other
主題 molar
キーワード
言語 en
主題Scheme Other
主題 NF-κB
キーワード
言語 en
主題Scheme Other
主題 tooth development
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
著者 山田, 茜

× 山田, 茜

en Yamada, Akane

ja 山田, 茜

Search repository
抄録
内容記述タイプ Abstract
内容記述 Objective: Hypohidrotic ectodermal dysplasia (HED) is a hereditary disorder characterized by abnormal structures and functions of the ectoderm-derived organs, including teeth. HED patients exhibit a variety of dental symptoms, such as hypodontia. Although disruption of the EDA/EDAR/EDARADD/NF-κB pathway is known to be responsible for HED, it remains unclear whether this pathway is involved in the process of enamel formation. Experimental subjects and methods: To address this question, we examined the mice overexpressing Ikkβ (an essential component required for the activation of NF-κB pathway) under the keratin 5 promoter (K5-Ikkβ). Results: Upregulation of the NF-κB pathway was confirmed in the ameloblasts of K5-Ikkβ mice. Premature abrasion was observed in the molars of K5-Ikkβ mice, which was accompanied by less mineralized enamel. However, no significant changes were observed in the enamel thickness and the pattern of enamel rods in K5-Ikkβ mice. Klk4 expression was significantly upregulated in the ameloblasts of K5-Ikkβ mice at the maturation stage, and the expression of its substrate, amelogenin, was remarkably reduced. This suggests that abnormal enamel observed in K5-Ikkβ mice was likely due to the compromised degradation of enamel protein at the maturation stage. Conclusion: Therefore, we could conclude that the overactivation of the NF-κB pathway impairs the process of amelogenesis.
言語 en
内容記述
内容記述タイプ Other
内容記述 Oral Diseases. 2020, 26(7), 1513-1522.
言語 en
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/odi.13384
権利
言語 en
権利情報 【○!C】 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved
学位名
言語 ja
学位名 博士(歯学)
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 13101
言語 ja
学位授与機関名 新潟大学
言語 en
学位授与機関名 Niigata University
学位授与年月日
学位授与年月日 2021-03-23
学位授与番号
学位授与番号 甲第4867号
学位記番号
内容記述タイプ Other
内容記述 新大院博(歯)第475号
言語 ja
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