@phdthesis{oai:niigata-u.repo.nii.ac.jp:02000363,
 author = {Yamada, Akane and 山田, 茜},
 month = {2022-04-15, 2022-04-15},
 note = {Objective: Hypohidrotic ectodermal dysplasia (HED) is a hereditary disorder characterized by abnormal structures and functions of the ectoderm-derived organs, including teeth. HED patients exhibit a variety of dental symptoms, such as hypodontia. Although disruption of the EDA/EDAR/EDARADD/NF-κB pathway is known to be responsible for HED, it remains unclear whether this pathway is involved in the process of enamel formation. Experimental subjects and methods: To address this question, we examined the mice overexpressing Ikkβ (an essential component required for the activation of NF-κB pathway) under the keratin 5 promoter (K5-Ikkβ). Results: Upregulation of the NF-κB pathway was confirmed in the ameloblasts of K5-Ikkβ mice. Premature abrasion was observed in the molars of K5-Ikkβ mice, which was accompanied by less mineralized enamel. However, no significant changes were observed in the enamel thickness and the pattern of enamel rods in K5-Ikkβ mice. Klk4 expression was significantly upregulated in the ameloblasts of K5-Ikkβ mice at the maturation stage, and the expression of its substrate, amelogenin, was remarkably reduced. This suggests that abnormal enamel observed in K5-Ikkβ mice was likely due to the compromised degradation of enamel protein at the maturation stage. Conclusion: Therefore, we could conclude that the overactivation of the NF-κB pathway impairs the process of amelogenesis., Oral Diseases. 2020, 26(7), 1513-1522., 新大院博(歯)第475号},
 school = {新潟大学, Niigata University},
 title = {Overactivation of the NF-κB pathway impairs molar enamel formation},
 year = {}
}