{"_buckets": {"deposit": "f3f08a8e-7009-412e-a15b-de254866ddf3"}, "_deposit": {"id": "2000173", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2000173"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:02000173", "sets": ["456", "1639700700075"]}, "author_link": [], "item_1627361970403": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2021-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1-3", "bibliographicPageEnd": "21", "bibliographicPageStart": "11", "bibliographicVolumeNumber": "135", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "ja"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "筋萎縮性側索硬化症(amyotrophic lateral sclerosis: ALS)は，上位運動ニューロン(upper motor neuron: UMN)および下位運動ニューロン(lower motor neuron: LMN)が侵される神経変性疾患である．病理学的には，運動神経細胞やグリア細胞に，TAR DNA-binding protein 43kDa(TDP-43)陽性の凝集体が認められる．このことから，病態として，異常TDP-43が，局所から伝播し広がっていくとする仮説が提唱されている．本研究では，この仮説を検証するため，特定の脳領域あるいは細胞種にTDP-43陽性凝集体を形成するマウスモデルの開発を目的とした．まず凝集体を作りやすい変異TDP-43を発現するアデノ随伴ウイルスを作製した．これを大脳皮質，脊髄，あるいは骨格筋に発現させ，特定の細胞種や領域に，TDP-43陽性凝集体を高効率に作成し得た．本研究で確立したマウスモデルは，TDP-43陽性凝集体の伝播を明らかとするのに貢献すると期待される．", "subitem_description_language": "ja", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会", "subitem_publisher_language": "ja"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0029-0440", "subitem_source_identifier_type": "PISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "坪口, 晋太朗", "creatorNameLang": "ja"}, {"creatorName": "Tsuboguchi, Shintaro", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2021-12-17"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "135(1-3)_11-21.pdf", "filesize": [{"value": "6.33MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": "6.33MB", "url": {"objectType": "fulltext", "url": "https://niigata-u.repo.nii.ac.jp/record/2000173/files/135(1-3)_11-21.pdf"}, "version_id": "e2264106-5145-4f7e-b6cd-e0a6e22aac22"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "筋萎縮性側索硬化症", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "TDP-43陽性凝集体", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "伝播", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "アデノ随伴ウイルス", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "マウスモデル", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "TDP-43病態伝播仮説の立証を目的としたウイルスベクターの作成", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "TDP-43病態伝播仮説の立証を目的としたウイルスベクターの作成", "subitem_title_language": "ja"}, {"subitem_title": "Development of Mouse ALS Model to Detect TDP-43 Inclusions and Spreading", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1639700700075"], "permalink_uri": "http://hdl.handle.net/10191/0002000173", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2021-12-17"}, "publish_date": "2021-12-17", "publish_status": "0", "recid": "2000173", "relation": {}, "relation_version_is_last": true, "title": ["TDP-43病態伝播仮説の立証を目的としたウイルスベクターの作成"], "weko_shared_id": -1}