WEKO3
AND
アイテム
{"_buckets": {"deposit": "f3f08a8e-7009-412e-a15b-de254866ddf3"}, "_deposit": {"id": "2000173", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2000173"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:02000173", "sets": []}, "author_link": [], "item_1627361970403": {"attribute_name": "\u51fa\u7248\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2021-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1-3", "bibliographicPageEnd": "21", "bibliographicPageStart": "11", "bibliographicVolumeNumber": "135", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "ja"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "\u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7(amyotrophic lateral sclerosis: ALS)\u306f\uff0c\u4e0a\u4f4d\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3(upper motor neuron: UMN)\u304a\u3088\u3073\u4e0b\u4f4d\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3(lower motor neuron: LMN)\u304c\u4fb5\u3055\u308c\u308b\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3067\u3042\u308b\uff0e\u75c5\u7406\u5b66\u7684\u306b\u306f\uff0c\u904b\u52d5\u795e\u7d4c\u7d30\u80de\u3084\u30b0\u30ea\u30a2\u7d30\u80de\u306b\uff0cTAR DNA-binding protein 43kDa(TDP-43)\u967d\u6027\u306e\u51dd\u96c6\u4f53\u304c\u8a8d\u3081\u3089\u308c\u308b\uff0e\u3053\u306e\u3053\u3068\u304b\u3089\uff0c\u75c5\u614b\u3068\u3057\u3066\uff0c\u7570\u5e38TDP-43\u304c\uff0c\u5c40\u6240\u304b\u3089\u4f1d\u64ad\u3057\u5e83\u304c\u3063\u3066\u3044\u304f\u3068\u3059\u308b\u4eee\u8aac\u304c\u63d0\u5531\u3055\u308c\u3066\u3044\u308b\uff0e\u672c\u7814\u7a76\u3067\u306f\uff0c\u3053\u306e\u4eee\u8aac\u3092\u691c\u8a3c\u3059\u308b\u305f\u3081\uff0c\u7279\u5b9a\u306e\u8133\u9818\u57df\u3042\u308b\u3044\u306f\u7d30\u80de\u7a2e\u306bTDP-43\u967d\u6027\u51dd\u96c6\u4f53\u3092\u5f62\u6210\u3059\u308b\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u306e\u958b\u767a\u3092\u76ee\u7684\u3068\u3057\u305f\uff0e\u307e\u305a\u51dd\u96c6\u4f53\u3092\u4f5c\u308a\u3084\u3059\u3044\u5909\u7570TDP-43\u3092\u767a\u73fe\u3059\u308b\u30a2\u30c7\u30ce\u968f\u4f34\u30a6\u30a4\u30eb\u30b9\u3092\u4f5c\u88fd\u3057\u305f\uff0e\u3053\u308c\u3092\u5927\u8133\u76ae\u8cea\uff0c\u810a\u9ac4\uff0c\u3042\u308b\u3044\u306f\u9aa8\u683c\u7b4b\u306b\u767a\u73fe\u3055\u305b\uff0c\u7279\u5b9a\u306e\u7d30\u80de\u7a2e\u3084\u9818\u57df\u306b\uff0cTDP-43\u967d\u6027\u51dd\u96c6\u4f53\u3092\u9ad8\u52b9\u7387\u306b\u4f5c\u6210\u3057\u5f97\u305f\uff0e\u672c\u7814\u7a76\u3067\u78ba\u7acb\u3057\u305f\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u306f\uff0cTDP-43\u967d\u6027\u51dd\u96c6\u4f53\u306e\u4f1d\u64ad\u3092\u660e\u3089\u304b\u3068\u3059\u308b\u306e\u306b\u8ca2\u732e\u3059\u308b\u3068\u671f\u5f85\u3055\u308c\u308b\uff0e", "subitem_description_language": "ja", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a", "subitem_publisher_language": "ja"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0029-0440", "subitem_source_identifier_type": "PISSN"}]}, "item_access_right": {"attribute_name": "\u30a2\u30af\u30bb\u30b9\u6a29", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u576a\u53e3, \u664b\u592a\u6717", "creatorNameLang": "ja"}, {"creatorName": "Tsuboguchi, Shintaro", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2021-12-17"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "135(1-3)_11-21.pdf", "filesize": [{"value": "6.33MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": "6.33MB", "url": {"objectType": "fulltext", "url": "https://niigata-u.repo.nii.ac.jp/record/2000173/files/135(1-3)_11-21.pdf"}, "version_id": "e2264106-5145-4f7e-b6cd-e0a6e22aac22"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "\u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "TDP-43\u967d\u6027\u51dd\u96c6\u4f53", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u4f1d\u64ad", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30a2\u30c7\u30ce\u968f\u4f34\u30a6\u30a4\u30eb\u30b9", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30de\u30a6\u30b9\u30e2\u30c7\u30eb", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "TDP-43\u75c5\u614b\u4f1d\u64ad\u4eee\u8aac\u306e\u7acb\u8a3c\u3092\u76ee\u7684\u3068\u3057\u305f\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u306e\u4f5c\u6210", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "TDP-43\u75c5\u614b\u4f1d\u64ad\u4eee\u8aac\u306e\u7acb\u8a3c\u3092\u76ee\u7684\u3068\u3057\u305f\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u306e\u4f5c\u6210", "subitem_title_language": "ja"}, {"subitem_title": "Development of Mouse ALS Model to Detect TDP-43 Inclusions and Spreading", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1639700700075"], "permalink_uri": "http://hdl.handle.net/10191/0002000173", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2021-12-17"}, "publish_date": "2021-12-17", "publish_status": "0", "recid": "2000173", "relation": {}, "relation_version_is_last": true, "title": ["TDP-43\u75c5\u614b\u4f1d\u64ad\u4eee\u8aac\u306e\u7acb\u8a3c\u3092\u76ee\u7684\u3068\u3057\u305f\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u306e\u4f5c\u6210"], "weko_shared_id": -1}
TDP-43病態伝播仮説の立証を目的としたウイルスベクターの作成
http://hdl.handle.net/10191/0002000173
49083477-76f5-45f9-aebb-eb4e57a436b6
| 名前 / ファイル | ライセンス | アクション | |
|---|---|---|---|
135(1-3)_11-21.pdf (6.33MB)
|
|
| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2021-12-17 | |||||||||
| タイトル | ||||||||||
| 言語 | ja | |||||||||
| タイトル | TDP-43病態伝播仮説の立証を目的としたウイルスベクターの作成 | |||||||||
| タイトル | ||||||||||
| 言語 | en | |||||||||
| タイトル | Development of Mouse ALS Model to Detect TDP-43 Inclusions and Spreading | |||||||||
| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| キーワード | ||||||||||
| 言語 | ja | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | 筋萎縮性側索硬化症 | |||||||||
| キーワード | ||||||||||
| 言語 | ja | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | TDP-43陽性凝集体 | |||||||||
| キーワード | ||||||||||
| 言語 | ja | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | 伝播 | |||||||||
| キーワード | ||||||||||
| 言語 | ja | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | アデノ随伴ウイルス | |||||||||
| キーワード | ||||||||||
| 言語 | ja | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | マウスモデル | |||||||||
| 資源タイプ | ||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| タイプ | departmental bulletin paper | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 著者 |
坪口, 晋太朗
× 坪口, 晋太朗
|
|||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | 筋萎縮性側索硬化症(amyotrophic lateral sclerosis: ALS)は，上位運動ニューロン(upper motor neuron: UMN)および下位運動ニューロン(lower motor neuron: LMN)が侵される神経変性疾患である．病理学的には，運動神経細胞やグリア細胞に，TAR DNA-binding protein 43kDa(TDP-43)陽性の凝集体が認められる．このことから，病態として，異常TDP-43が，局所から伝播し広がっていくとする仮説が提唱されている．本研究では，この仮説を検証するため，特定の脳領域あるいは細胞種にTDP-43陽性凝集体を形成するマウスモデルの開発を目的とした．まず凝集体を作りやすい変異TDP-43を発現するアデノ随伴ウイルスを作製した．これを大脳皮質，脊髄，あるいは骨格筋に発現させ，特定の細胞種や領域に，TDP-43陽性凝集体を高効率に作成し得た．本研究で確立したマウスモデルは，TDP-43陽性凝集体の伝播を明らかとするのに貢献すると期待される． | |||||||||
| 言語 | ja | |||||||||
| 書誌情報 |
ja : 新潟医学会雑誌 巻 135, 号 1-3, p. 11-21, 発行日 2021-03 |
|||||||||
| 出版者 | ||||||||||
| 言語 | ja | |||||||||
| 出版者 | 新潟医学会 | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 0029-0440 | |||||||||
| 書誌レコードID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AN00182415 | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
