{"created":"2021-12-17T00:48:55.294788+00:00","id":2000173,"links":{},"metadata":{"_buckets":{"deposit":"f3f08a8e-7009-412e-a15b-de254866ddf3"},"_deposit":{"id":"2000173","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"2000173"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:02000173","sets":["453:456","471:537:538:1639700700075"]},"author_link":[],"item_1627361970403":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-3","bibliographicPageEnd":"21","bibliographicPageStart":"11","bibliographicVolumeNumber":"135","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"ja"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"筋萎縮性側索硬化症(amyotrophic lateral sclerosis: ALS)は，上位運動ニューロン(upper motor neuron: UMN)および下位運動ニューロン(lower motor neuron: LMN)が侵される神経変性疾患である．病理学的には，運動神経細胞やグリア細胞に，TAR DNA-binding protein 43kDa(TDP-43)陽性の凝集体が認められる．このことから，病態として，異常TDP-43が，局所から伝播し広がっていくとする仮説が提唱されている．本研究では，この仮説を検証するため，特定の脳領域あるいは細胞種にTDP-43陽性凝集体を形成するマウスモデルの開発を目的とした．まず凝集体を作りやすい変異TDP-43を発現するアデノ随伴ウイルスを作製した．これを大脳皮質，脊髄，あるいは骨格筋に発現させ，特定の細胞種や領域に，TDP-43陽性凝集体を高効率に作成し得た．本研究で確立したマウスモデルは，TDP-43陽性凝集体の伝播を明らかとするのに貢献すると期待される．","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会","subitem_publisher_language":"ja"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0029-0440","subitem_source_identifier_type":"PISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"坪口, 晋太朗","creatorNameLang":"ja"},{"creatorName":"Tsuboguchi, Shintaro","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-12-17"}],"displaytype":"detail","filename":"135(1-3)_11-21.pdf","filesize":[{"value":"6.33MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://niigata-u.repo.nii.ac.jp/record/2000173/files/135(1-3)_11-21.pdf"},"version_id":"e2264106-5145-4f7e-b6cd-e0a6e22aac22"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"筋萎縮性側索硬化症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"TDP-43陽性凝集体","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"伝播","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"アデノ随伴ウイルス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"マウスモデル","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"TDP-43病態伝播仮説の立証を目的としたウイルスベクターの作成","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"TDP-43病態伝播仮説の立証を目的としたウイルスベクターの作成","subitem_title_language":"ja"},{"subitem_title":"Development of Mouse ALS Model to Detect TDP-43 Inclusions and Spreading","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1639700700075"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-12-17"},"publish_date":"2021-12-17","publish_status":"0","recid":"2000173","relation_version_is_last":true,"title":["TDP-43病態伝播仮説の立証を目的としたウイルスベクターの作成"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-15T04:35:37.109306+00:00"}