{"_buckets": {"deposit": "f0b37fef-459c-4c11-a574-e35e223e8519"}, "_deposit": {"id": "19817", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "19817"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00019817", "sets": ["456", "1156"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Toward Better Understanding of Molecular Mechanisms of Neurologic Diseases (Commemorative Lecture: Twenty-fifth Anniversary of the Brain Research Institute, Niigata University, July25,1992)"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1993-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "11", "bibliographicPageEnd": "980", "bibliographicPageStart": "972", "bibliographicVolumeNumber": "107", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Recent advances in molecular genetics have made it possible to identify genes for various hereditary neurodegenerative disorders. The approach, which is now called positional cloning, consists of two steps. The first step is to determine the chromosomal localizations of disease genes by linkage analyses. The second step is to determine the causative genes themselves. As many microsatellite markers have been described, the linkage analysis can now be performed far more effectively. Development of new technologies including pulsed-field gel electrophoresis and cloning of several hundred kilobases of genomic DNA using yeast artificial chromosomes have also brought new effective strategies for the positional cloning. Our laboratory has been involved in identification of genes for neurologic diseases including adrenoleukodystrophy and various forms of spinocerebellar degenerations. Application of microsatellite polymorphisms for the linkage analysis of early-onset ataxia associated with hypoalbuminemia (EOAHA) was described. As a new technology for positional cloning, an improved hncDNA (heterogenous nuclear RNA-complementary DNA) cloning method was described. Our approaches toward the identification of the causative genes for these diseases and better understanding of the molecular mechanisms of neurodegenerative diseases are discussed.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "122849", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Tsuji, Shoji"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "辻, 省次"}], "nameIdentifiers": [{"nameIdentifier": "122848", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "107(11)_972-980.pdf", "filesize": [{"value": "3.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 3500000.0, "url": {"label": "107(11)_972-980.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/19817/files/107(11)_972-980.pdf"}, "version_id": "955c84d9-f3d5-4f10-b018-004b067d8543"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "positional cloning", "subitem_subject_scheme": "Other"}, {"subitem_subject": "linkage analysis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "neurodegenerative disease", "subitem_subject_scheme": "Other"}, {"subitem_subject": "microsatellite polymorphism", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ポジショナルクローニング", "subitem_subject_scheme": "Other"}, {"subitem_subject": "連鎖解析", "subitem_subject_scheme": "Other"}, {"subitem_subject": "神経変性疾患", "subitem_subject_scheme": "Other"}, {"subitem_subject": "マイクロサテライト多型", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "1) 神経疾患の分子メカニズム(新潟大学脳研究所創立25周年記念講演会)", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "1) 神経疾患の分子メカニズム(新潟大学脳研究所創立25周年記念講演会)"}, {"subitem_title": "1) 神経疾患の分子メカニズム(新潟大学脳研究所創立25周年記念講演会)", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1156"], "permalink_uri": "http://hdl.handle.net/10191/37808", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-02-05"}, "publish_date": "2016-02-05", "publish_status": "0", "recid": "19817", "relation": {}, "relation_version_is_last": true, "title": ["1) 神経疾患の分子メカニズム(新潟大学脳研究所創立25周年記念講演会)"], "weko_shared_id": null}