{"_buckets": {"deposit": "656b7453-0a2c-4af4-b4b7-108446d06aa0"}, "_deposit": {"id": "19593", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "19593"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00019593"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Production of IL-1\u03b2, TNF-\u03b1 and IFN-\u03b3 from Alveolar Cells in Patients with Sarcoidesis"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1994-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "39", "bibliographicPageStart": "32", "bibliographicVolumeNumber": "108", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "We studied the production of IL-1\u03b2, TNF-\u03b1 and IFN-\u03b3 by alveolar cells obtained by bronchoalveolar lavage (BAL) in patients with sarcoidosis. The culture supernatant of alveolar macrophages (AMs) and peripheral blood monocytes (PB-Mo) of patients with sarcoidosis and control subjects were assayed for IL-1\u03b2 and TNF-\u03b1 using ELISA system. IFN-\u03b3 was also measured in the culture supernatants of BAL-lymphocytes (BAL-Ly) and peripheral blood lymphocytes (PB-Ly) by RIA system. In patients with sarcoidosis, the production of IL-1\u03b2 was significantly higher in both LPS-stimulated AMs and PB-Mo than untreated AMs and PB-Mo. The content of TNF-\u03b1 was significantly higher in the supernatant from lipopolysaccharide (LPS) stimulated AMs than that from untreated AMs. However, there was no significant difference in TNF-\u03b1 content of the supernatant between LPS-stimulated and untreated PB-Mo. Concerning IFN-\u03b3, the culture supernatant from both phytohemagglutinin stimulated BAL-Ly and PB-Ly contained more IFN-\u03b3 than in untreated BAL-Ly and PB-ly. This study demonstrated that AMs from patients with sarcoidosis increased the production of TNF-\u03b1 and that this increase was compartmentalized to the lungs, since there was significant difference in TNF-\u03b1 production between LPS-stimulated AMs and PB-Mo. It is suggested that acceleratod TNF-\u03b1 release by AMs play a role in immune effector cells activation in the pulmonary sarcoidosis lesions.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "121690", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Hirahara, Katsumi"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u5e73\u539f, \u514b\u5df1"}], "nameIdentifiers": [{"nameIdentifier": "121689", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-08"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "108(1)_32-39.pdf", "filesize": [{"value": "1.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1200000.0, "url": {"label": "108(1)_32-39.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/19593/files/108(1)_32-39.pdf"}, "version_id": "82716f13-f04a-4045-8640-67dfcfda4436"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "sarcoidosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "bronchoalveolar lavage", "subitem_subject_scheme": "Other"}, {"subitem_subject": "interleukin-1\u03b2", "subitem_subject_scheme": "Other"}, {"subitem_subject": "umor necrosis factor-\u03b1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "interferon-\u03b3", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30b5\u30eb\u30b3\u30a4\u30c9\u30fc\u30b7\u30b9", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u6c17\u7ba1\u652f\u80ba\u80de\u6d17\u6d44", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IL-1\u03b2", "subitem_subject_scheme": "Other"}, {"subitem_subject": "TNF-\u03b1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IFN-\u03b3", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u30b5\u30eb\u30b3\u30a4\u30c9\u30fc\u30b7\u30b9\u306b\u304a\u3051\u308b\u80ba\u80de\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8IL-1\u03b2, TNF-\u03b1\u304a\u3088\u3073\u80ba\u80de\u30ea\u30f3\u30d1\u7403IFN-\u03b3\u306e\u7523\u751f", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u30b5\u30eb\u30b3\u30a4\u30c9\u30fc\u30b7\u30b9\u306b\u304a\u3051\u308b\u80ba\u80de\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8IL-1\u03b2, TNF-\u03b1\u304a\u3088\u3073\u80ba\u80de\u30ea\u30f3\u30d1\u7403IFN-\u03b3\u306e\u7523\u751f"}, {"subitem_title": "\u30b5\u30eb\u30b3\u30a4\u30c9\u30fc\u30b7\u30b9\u306b\u304a\u3051\u308b\u80ba\u80de\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8IL-1\u03b2, TNF-\u03b1\u304a\u3088\u3073\u80ba\u80de\u30ea\u30f3\u30d1\u7403IFN-\u03b3\u306e\u7523\u751f", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1154"], "permalink_uri": "http://hdl.handle.net/10191/37895", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2016-02-08"}, "publish_date": "2016-02-08", "publish_status": "0", "recid": "19593", "relation": {}, "relation_version_is_last": true, "title": ["\u30b5\u30eb\u30b3\u30a4\u30c9\u30fc\u30b7\u30b9\u306b\u304a\u3051\u308b\u80ba\u80de\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8IL-1\u03b2, TNF-\u03b1\u304a\u3088\u3073\u80ba\u80de\u30ea\u30f3\u30d1\u7403IFN-\u03b3\u306e\u7523\u751f"], "weko_shared_id": null}