WEKO3
アイテム
サルコイドーシスにおける肺胞マクロファージIL-1β, TNF-αおよび肺胞リンパ球IFN-γの産生
http://hdl.handle.net/10191/37895
http://hdl.handle.net/10191/3789582c4d0d1-b020-4336-a7f0-c298751ac65d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
108(1)_32-39.pdf (1.2 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-02-08 | |||||
| タイトル | ||||||
| タイトル | サルコイドーシスにおける肺胞マクロファージIL-1β, TNF-αおよび肺胞リンパ球IFN-γの産生 | |||||
| タイトル | ||||||
| タイトル | サルコイドーシスにおける肺胞マクロファージIL-1β, TNF-αおよび肺胞リンパ球IFN-γの産生 | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | sarcoidosis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | bronchoalveolar lavage | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | interleukin-1β | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | umor necrosis factor-α | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | interferon-γ | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | サルコイドーシス | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 気管支肺胞洗浄 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | IL-1β | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | TNF-α | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | IFN-γ | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| その他のタイトル | ||||||
| その他のタイトル | Production of IL-1β, TNF-α and IFN-γ from Alveolar Cells in Patients with Sarcoidesis | |||||
| 著者 |
平原, 克己
× 平原, 克己 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 121690 | |||||
| 姓名 | Hirahara, Katsumi | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We studied the production of IL-1β, TNF-α and IFN-γ by alveolar cells obtained by bronchoalveolar lavage (BAL) in patients with sarcoidosis. The culture supernatant of alveolar macrophages (AMs) and peripheral blood monocytes (PB-Mo) of patients with sarcoidosis and control subjects were assayed for IL-1β and TNF-α using ELISA system. IFN-γ was also measured in the culture supernatants of BAL-lymphocytes (BAL-Ly) and peripheral blood lymphocytes (PB-Ly) by RIA system. In patients with sarcoidosis, the production of IL-1β was significantly higher in both LPS-stimulated AMs and PB-Mo than untreated AMs and PB-Mo. The content of TNF-α was significantly higher in the supernatant from lipopolysaccharide (LPS) stimulated AMs than that from untreated AMs. However, there was no significant difference in TNF-α content of the supernatant between LPS-stimulated and untreated PB-Mo. Concerning IFN-γ, the culture supernatant from both phytohemagglutinin stimulated BAL-Ly and PB-Ly contained more IFN-γ than in untreated BAL-Ly and PB-ly. This study demonstrated that AMs from patients with sarcoidosis increased the production of TNF-α and that this increase was compartmentalized to the lungs, since there was significant difference in TNF-α production between LPS-stimulated AMs and PB-Mo. It is suggested that acceleratod TNF-α release by AMs play a role in immune effector cells activation in the pulmonary sarcoidosis lesions. | |||||
| 書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 108, 号 1, p. 32-39, 発行日 1994-01 |
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| 出版者 | ||||||
| 出版者 | 新潟医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00290440 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00182415 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
