{"created":"2021-03-01T06:24:27.800654+00:00","id":19593,"links":{},"metadata":{"_buckets":{"deposit":"656b7453-0a2c-4af4-b4b7-108446d06aa0"},"_deposit":{"id":"19593","owners":[],"pid":{"revision_id":0,"type":"depid","value":"19593"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00019593","sets":["453:456","471:537:538:1154"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Production of IL-1β, TNF-α and IFN-γ from Alveolar Cells in Patients with Sarcoidesis"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1994-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"39","bibliographicPageStart":"32","bibliographicVolumeNumber":"108","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We studied the production of IL-1β, TNF-α and IFN-γ by alveolar cells obtained by bronchoalveolar lavage (BAL) in patients with sarcoidosis. The culture supernatant of alveolar macrophages (AMs) and peripheral blood monocytes (PB-Mo) of patients with sarcoidosis and control subjects were assayed for IL-1β and TNF-α using ELISA system. IFN-γ was also measured in the culture supernatants of BAL-lymphocytes (BAL-Ly) and peripheral blood lymphocytes (PB-Ly) by RIA system. In patients with sarcoidosis, the production of IL-1β was significantly higher in both LPS-stimulated AMs and PB-Mo than untreated AMs and PB-Mo. The content of TNF-α was significantly higher in the supernatant from lipopolysaccharide (LPS) stimulated AMs than that from untreated AMs. However, there was no significant difference in TNF-α content of the supernatant between LPS-stimulated and untreated PB-Mo. Concerning IFN-γ, the culture supernatant from both phytohemagglutinin stimulated BAL-Ly and PB-Ly contained more IFN-γ than in untreated BAL-Ly and PB-ly. This study demonstrated that AMs from patients with sarcoidosis increased the production of TNF-α and that this increase was compartmentalized to the lungs, since there was significant difference in TNF-α production between LPS-stimulated AMs and PB-Mo. It is suggested that acceleratod TNF-α release by AMs play a role in immune effector cells activation in the pulmonary sarcoidosis lesions.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"121690","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Hirahara, Katsumi"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"平原, 克己"}],"nameIdentifiers":[{"nameIdentifier":"121689","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-08"}],"displaytype":"detail","filename":"108(1)_32-39.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"108(1)_32-39.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/19593/files/108(1)_32-39.pdf"},"version_id":"82716f13-f04a-4045-8640-67dfcfda4436"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"sarcoidosis","subitem_subject_scheme":"Other"},{"subitem_subject":"bronchoalveolar lavage","subitem_subject_scheme":"Other"},{"subitem_subject":"interleukin-1β","subitem_subject_scheme":"Other"},{"subitem_subject":"umor necrosis factor-α","subitem_subject_scheme":"Other"},{"subitem_subject":"interferon-γ","subitem_subject_scheme":"Other"},{"subitem_subject":"サルコイドーシス","subitem_subject_scheme":"Other"},{"subitem_subject":"気管支肺胞洗浄","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-1β","subitem_subject_scheme":"Other"},{"subitem_subject":"TNF-α","subitem_subject_scheme":"Other"},{"subitem_subject":"IFN-γ","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"サルコイドーシスにおける肺胞マクロファージIL-1β, TNF-αおよび肺胞リンパ球IFN-γの産生","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"サルコイドーシスにおける肺胞マクロファージIL-1β, TNF-αおよび肺胞リンパ球IFN-γの産生"},{"subitem_title":"サルコイドーシスにおける肺胞マクロファージIL-1β, TNF-αおよび肺胞リンパ球IFN-γの産生","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1154"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-02-08"},"publish_date":"2016-02-08","publish_status":"0","recid":"19593","relation_version_is_last":true,"title":["サルコイドーシスにおける肺胞マクロファージIL-1β, TNF-αおよび肺胞リンパ球IFN-γの産生"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:50:29.468068+00:00"}