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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第108巻第11号

インスリン非依存型糖尿病における尿中セルロプラスミンの排泄

http://hdl.handle.net/10191/40478
http://hdl.handle.net/10191/40478
651866a8-a855-45ec-9e8c-4cc4de0af0a3
名前 / ファイル ライセンス アクション
108(11)_839-846.pdf 108(11)_839-846.pdf (1.3 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-03-29
タイトル
タイトル インスリン非依存型糖尿病における尿中セルロプラスミンの排泄
タイトル
言語 en
タイトル インスリン非依存型糖尿病における尿中セルロプラスミンの排泄
言語
言語 jpn
キーワード
主題Scheme Other
主題 Ceruloplasmin
キーワード
主題Scheme Other
主題 urinary excretion rate
キーワード
主題Scheme Other
主題 NIDDM
キーワード
主題Scheme Other
主題 charge selectivity
キーワード
主題Scheme Other
主題 セルロプラスミン
キーワード
主題Scheme Other
主題 尿中排泄率
キーワード
主題Scheme Other
主題 インスリン非依存型糖尿病
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Urinary Ceruloplasmin Excretion in Non-insulin Dependent Diabetes Mellitus
著者 宇佐美, 明男

× 宇佐美, 明男

WEKO 117956

宇佐美, 明男

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著者別名
識別子 117957
識別子Scheme WEKO
姓名 Usami, Akio
抄録
内容記述タイプ Abstract
内容記述 Ceruloplasmin levels in serum samples and in timed overnight urine samples were measured in patients with NIDDM and healthy controls by an immunoradiometric assay. Any crossreactivitise to several kinds of plasma proteins were not found in this assay. Furthermore, a lineal correlation was seen between ceruloplasmin levels and the serially diluted samples. The findings suggested that ceruloplasmin detected by this assay was ceruloplasmin itself. Urinary excretion rate of ceruloplasmin (CER) increased in parallel with rise of albuminuria (r=0.86). It was significantly higher in patients with normoalbuminuria than in healthy controls, higher in patients with microalbuminuria than in ones with normoalbuminuria, and higher in patients with macroalbuminuria than in ones with microalbuminuria. In view of the findings that pI of ceruloplasmin (pI 4.4) is more acidic than pI of albumin and that mean blood pressure in normoalbuminuric patients with enhanced CER were not different from that in normoalbuminuria patients with normal CER, it seems reasonable to think that enhanced CER in a part of non-insulin dependent diabetic patients with normoalbuminuria was not due to intraglomerular hydraulic pressure, but to the changes of charge selectivity in the glomerular basement membrane. Furthermore, the changes of charge selectivity in the glomerular basement membrane may progress in parallel with the exacerbation of diabetic nephropathy.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 108, 号 11, p. 839-846, 発行日 1994-11
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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