@article{oai:niigata-u.repo.nii.ac.jp:00018898,
 author = {宇佐美, 明男},
 issue = {11},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Nov},
 note = {Ceruloplasmin levels in serum samples and in timed overnight urine samples were measured in patients with NIDDM and healthy controls by an immunoradiometric assay. Any crossreactivitise to several kinds of plasma proteins were not found in this assay. Furthermore, a lineal correlation was seen between ceruloplasmin levels and the serially diluted samples. The findings suggested that ceruloplasmin detected by this assay was ceruloplasmin itself. Urinary excretion rate of ceruloplasmin (CER) increased in parallel with rise of albuminuria (r=0.86). It was significantly higher in patients with normoalbuminuria than in healthy controls, higher in patients with microalbuminuria than in ones with normoalbuminuria, and higher in patients with macroalbuminuria than in ones with microalbuminuria. In view of the findings that pI of ceruloplasmin (pI 4.4) is more acidic than pI of albumin and that mean blood pressure in normoalbuminuric patients with enhanced CER were not different from that in normoalbuminuria patients with normal CER, it seems reasonable to think that enhanced CER in a part of non-insulin dependent diabetic patients with normoalbuminuria was not due to intraglomerular hydraulic pressure, but to the changes of charge selectivity in the glomerular basement membrane. Furthermore, the changes of charge selectivity in the glomerular basement membrane may progress in parallel with the exacerbation of diabetic nephropathy.},
 pages = {839--846},
 title = {インスリン非依存型糖尿病における尿中セルロプラスミンの排泄},
 volume = {108},
 year = {1994}
}