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Although the pathomechanism of this disease is considered to be multifactorial, estrogen depletion seems to be an initiating event causing bone loss. Estrogen receptors are found in rodent and human osteoblast like cells as well as in avian osteoclasts suggesting that estrogen can directly act on skeletal tissue. Furthermore, estrogen defficiency causes not only systemic changes of PTH and/or vitamin D metabolism but also changes of local bone resorbing factors released from monocytes. Aging is the additional causative factor of bone loss. Reduction of calcium absorption from gut becomes more serious long after menopause. Synthesis of active vitamin D in kidney is also reduced. Malabsorption of calcium may result in hyperparathyroid function for some period of time in elderly people. But since this state is likely to stabilize with time, bone turnover seems to be lowered with decreased number of osteoblasts.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "117907", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Tanizawa, Tatsuhiko"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u8c37\u6fa4, \u9f8d\u5f66"}], "nameIdentifiers": [{"nameIdentifier": "117906", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-08"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "108(11)_804-810.pdf", "filesize": [{"value": "1.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1000000.0, "url": {"label": "108(11)_804-810.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/18892/files/108(11)_804-810.pdf"}, "version_id": "4db156f9-50d0-46aa-a227-0a370b960bae"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "involutinal osteoporosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "vitamin D", "subitem_subject_scheme": "Other"}, {"subitem_subject": "PTH", "subitem_subject_scheme": "Other"}, {"subitem_subject": "estrogen", "subitem_subject_scheme": "Other"}, {"subitem_subject": "bone turnover", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u9000\u884c\u671f\u9aa8\u7c97\u9b06\u75c7", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30d3\u30bf\u30df\u30f3D", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u4e0a\u76ae\u5c0f\u4f53\u30db\u30eb\u30e2\u30f3", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u9aa8\u4ee3\u8b1d\u56de\u8ee2", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "1)\u9000\u884c\u671f\u9aa8\u7c97\u9b06\u75c7\u306e\u75c5\u614b(\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u9aa8\u7c97\u9b06\u75c7\u306e\u75c5\u614b\u30fb\u6cbb\u7642\u30fb\u4e88\u9632, \u7b2c493\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "1)\u9000\u884c\u671f\u9aa8\u7c97\u9b06\u75c7\u306e\u75c5\u614b(\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u9aa8\u7c97\u9b06\u75c7\u306e\u75c5\u614b\u30fb\u6cbb\u7642\u30fb\u4e88\u9632, \u7b2c493\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)"}, {"subitem_title": "1)\u9000\u884c\u671f\u9aa8\u7c97\u9b06\u75c7\u306e\u75c5\u614b(\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u9aa8\u7c97\u9b06\u75c7\u306e\u75c5\u614b\u30fb\u6cbb\u7642\u30fb\u4e88\u9632, \u7b2c493\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1144"], "permalink_uri": "http://hdl.handle.net/10191/40470", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2016-03-29"}, "publish_date": "2016-03-29", "publish_status": "0", "recid": "18892", "relation": {}, "relation_version_is_last": true, "title": ["1)\u9000\u884c\u671f\u9aa8\u7c97\u9b06\u75c7\u306e\u75c5\u614b(\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u9aa8\u7c97\u9b06\u75c7\u306e\u75c5\u614b\u30fb\u6cbb\u7642\u30fb\u4e88\u9632, \u7b2c493\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)"], "weko_shared_id": null}