@article{oai:niigata-u.repo.nii.ac.jp:00018892,
 author = {谷澤, 龍彦},
 issue = {11},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Nov},
 note = {Bone loss enhanced by menopause and aging is recognized as involutional osteoporosis. Although the pathomechanism of this disease is considered to be multifactorial, estrogen depletion seems to be an initiating event causing bone loss. Estrogen receptors are found in rodent and human osteoblast like cells as well as in avian osteoclasts suggesting that estrogen can directly act on skeletal tissue. Furthermore, estrogen defficiency causes not only systemic changes of PTH and/or vitamin D metabolism but also changes of local bone resorbing factors released from monocytes. Aging is the additional causative factor of bone loss. Reduction of calcium absorption from gut becomes more serious long after menopause. Synthesis of active vitamin D in kidney is also reduced. Malabsorption of calcium may result in hyperparathyroid function for some period of time in elderly people. But since this state is likely to stabilize with time, bone turnover seems to be lowered with decreased number of osteoblasts.},
 pages = {804--810},
 title = {1)退行期骨粗鬆症の病態(シンポジウム 骨粗鬆症の病態・治療・予防, 第493回新潟医学会)},
 volume = {108},
 year = {1994}
}