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This disease is life threatening because of the obstruction of micro-circulation. Although there are some therapeutic ways for the disease, it is difficult for the patients to obtain long term survival. A lot of patients are waiting for developing a new therapy such as a gene therapy. There are several ways for gene therapy of sickle cell disease, we thought that the expression of \u03b3-globin gene at adult stage might be the best way for the therapy. We have developed the backbone of the vector we would try to use for the gene therapy. The vector may consist; (1) insulator at the both sides, (2) globin gene with the promoter, (3) a strong enhancer such as the LCR (Locus Control Region), (4) the gene element for the in vivo selection, such as a drug resistance gene.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "112778", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Furukawa, Tatsuo"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u53e4\u5ddd, \u9054\u96c4"}], "nameIdentifiers": [{"nameIdentifier": "112777", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-08"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "110(8)_316-318.pdf", "filesize": [{"value": "559.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 559500.0, "url": {"label": "110(8)_316-318.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/17964/files/110(8)_316-318.pdf"}, "version_id": "a1e8e895-26b8-454a-a174-c3f81fbe74b6"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "gene therapy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Sickle cell disease", "subitem_subject_scheme": "Other"}, {"subitem_subject": "LCR", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u907a\u4f1d\u5b50\u6cbb\u7642", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u938c\u72b6\u8ca7\u8840", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "4) \u938c\u72b6\u8ca7\u8840\u306e\u907a\u4f1d\u5b50\u6cbb\u7642\uff08\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u907a\u4f1d\u5b50\u6cbb\u7642\u3092\u3081\u3050\u308b\u8af8\u554f\u984c, \u7b2c509\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "4) \u938c\u72b6\u8ca7\u8840\u306e\u907a\u4f1d\u5b50\u6cbb\u7642\uff08\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u907a\u4f1d\u5b50\u6cbb\u7642\u3092\u3081\u3050\u308b\u8af8\u554f\u984c, \u7b2c509\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)"}, {"subitem_title": "4) \u938c\u72b6\u8ca7\u8840\u306e\u907a\u4f1d\u5b50\u6cbb\u7642\uff08\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u907a\u4f1d\u5b50\u6cbb\u7642\u3092\u3081\u3050\u308b\u8af8\u554f\u984c, \u7b2c509\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1127"], "permalink_uri": "http://hdl.handle.net/10191/43252", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2016-08-19"}, "publish_date": "2016-08-19", "publish_status": "0", "recid": "17964", "relation": {}, "relation_version_is_last": true, "title": ["4) \u938c\u72b6\u8ca7\u8840\u306e\u907a\u4f1d\u5b50\u6cbb\u7642\uff08\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u907a\u4f1d\u5b50\u6cbb\u7642\u3092\u3081\u3050\u308b\u8af8\u554f\u984c, \u7b2c509\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)"], "weko_shared_id": null}