{"created":"2021-03-01T06:22:41.060892+00:00","id":17964,"links":{},"metadata":{"_buckets":{"deposit":"e97f9707-cc55-4a57-821d-14c65557eeac"},"_deposit":{"id":"17964","owners":[],"pid":{"revision_id":0,"type":"depid","value":"17964"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00017964","sets":["453:456","471:537:538:1127"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Gene Therapy for Sickle Cell Disease (Gene Therapy : Advances in Research and Treatment)"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"318","bibliographicPageStart":"316","bibliographicVolumeNumber":"110","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Sickle cell disease is the one of the molecular disease with a point mutation at the 6th amino in β globin gene. This disease is life threatening because of the obstruction of micro-circulation. Although there are some therapeutic ways for the disease, it is difficult for the patients to obtain long term survival. A lot of patients are waiting for developing a new therapy such as a gene therapy. There are several ways for gene therapy of sickle cell disease, we thought that the expression of γ-globin gene at adult stage might be the best way for the therapy. We have developed the backbone of the vector we would try to use for the gene therapy. The vector may consist; (1) insulator at the both sides, (2) globin gene with the promoter, (3) a strong enhancer such as the LCR (Locus Control Region), (4) the gene element for the in vivo selection, such as a drug resistance gene.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"112778","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Furukawa, Tatsuo"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"古川, 達雄"}],"nameIdentifiers":[{"nameIdentifier":"112777","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-08"}],"displaytype":"detail","filename":"110(8)_316-318.pdf","filesize":[{"value":"559.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"110(8)_316-318.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/17964/files/110(8)_316-318.pdf"},"version_id":"a1e8e895-26b8-454a-a174-c3f81fbe74b6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"gene therapy","subitem_subject_scheme":"Other"},{"subitem_subject":"Sickle cell disease","subitem_subject_scheme":"Other"},{"subitem_subject":"LCR","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子治療","subitem_subject_scheme":"Other"},{"subitem_subject":"鎌状貧血","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"4) 鎌状貧血の遺伝子治療（シンポジウム 遺伝子治療をめぐる諸問題, 第509回新潟医学会)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"4) 鎌状貧血の遺伝子治療（シンポジウム 遺伝子治療をめぐる諸問題, 第509回新潟医学会)"},{"subitem_title":"4) 鎌状貧血の遺伝子治療（シンポジウム 遺伝子治療をめぐる諸問題, 第509回新潟医学会)","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1127"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-08-19"},"publish_date":"2016-08-19","publish_status":"0","recid":"17964","relation_version_is_last":true,"title":["4) 鎌状貧血の遺伝子治療（シンポジウム 遺伝子治療をめぐる諸問題, 第509回新潟医学会)"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:49:16.859519+00:00"}