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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第111巻第7号

モルモット灌流心におけるnicorandilおよびcromakalimの冠流量増加作用におよぼすL-nitroarginineの影響について

http://hdl.handle.net/10191/45157
http://hdl.handle.net/10191/45157
ae717790-508f-4584-ae78-0659820ba501
名前 / ファイル ライセンス アクション
111(7)_452-459.pdf 111(7)_452-459.pdf (1.1 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-12-21
タイトル
タイトル モルモット灌流心におけるnicorandilおよびcromakalimの冠流量増加作用におよぼすL-nitroarginineの影響について
タイトル
言語 en
タイトル モルモット灌流心におけるnicorandilおよびcromakalimの冠流量増加作用におよぼすL-nitroarginineの影響について
言語
言語 jpn
キーワード
主題Scheme Other
主題 K^+ channel opener
キーワード
主題Scheme Other
主題 EDRF
キーワード
主題Scheme Other
主題 L-nitroarginine
キーワード
主題Scheme Other
主題 coronary vasodilation
キーワード
主題Scheme Other
主題 isolated guinea pig heart
キーワード
主題Scheme Other
主題 K^+ チャネル開口薬
キーワード
主題Scheme Other
主題 内皮由来拡張因子
キーワード
主題Scheme Other
主題 L-ニトロアルギニン
キーワード
主題Scheme Other
主題 冠血管拡張
キーワード
主題Scheme Other
主題 モルモット摘出心
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Influence of L-Nitroarginine on Nicorandil- and Cromakalim-Induced Increases in Coronary Flow in Isolated Guinea Pig Heart
著者 神, 裕雅

× 神, 裕雅

WEKO 109180

神, 裕雅

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著者別名
識別子 109181
識別子Scheme WEKO
姓名 Jin, Hiromasa
抄録
内容記述タイプ Abstract
内容記述 Possible contribution of endothelium-derived relaxing factor (EDRF) to nicorandil- and cromakalim-induced coronary vasodilations was studied in isolated guinea pig hearts. Increases in coronary flow induced by nicorandil, cromakalim and adenosine were significantly inhibited by pretreatment with glibenclamide, an antagonist of ATP sensitive K^+ channel, while those by acetylcholine and papaverine were not. Pretreatment with L-nitroarginine(L-NA), an inhibitor of constitutive nitric oxide synthetase, or with methylene blue (MB), an inhibitor of guanylate cyclase, resulted in a significant inhibition of nicorandil-, cromakalim-, acetylcholine- and adenosine-induced increases in coronary flow. Papaverine-induced increase was not affected by pretreatment with L-NA or MB. These results suggest that the release of EDRF from vascular endothelium is responsible in part for coronary vasodilation induced by nicorandil and cromakalim.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 111, 号 7, p. 452-459, 発行日 1997-07
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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