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Increases in coronary flow induced by nicorandil, cromakalim and adenosine were significantly inhibited by pretreatment with glibenclamide, an antagonist of ATP sensitive K^+ channel, while those by acetylcholine and papaverine were not. Pretreatment with L-nitroarginine(L-NA), an inhibitor of constitutive nitric oxide synthetase, or with methylene blue (MB), an inhibitor of guanylate cyclase, resulted in a significant inhibition of nicorandil-, cromakalim-, acetylcholine- and adenosine-induced increases in coronary flow. Papaverine-induced increase was not affected by pretreatment with L-NA or MB. These results suggest that the release of EDRF from vascular endothelium is responsible in part for coronary vasodilation induced by nicorandil and cromakalim.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "109181", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Jin, Hiromasa"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u795e, \u88d5\u96c5"}], "nameIdentifiers": [{"nameIdentifier": "109180", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-08"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "111(7)_452-459.pdf", "filesize": [{"value": "1.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1100000.0, "url": {"label": "111(7)_452-459.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/17289/files/111(7)_452-459.pdf"}, "version_id": "7052a0ae-e839-48bf-bea7-3f89a838e3c0"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "K^+ channel opener", "subitem_subject_scheme": "Other"}, {"subitem_subject": "EDRF", "subitem_subject_scheme": "Other"}, {"subitem_subject": "L-nitroarginine", "subitem_subject_scheme": "Other"}, {"subitem_subject": "coronary vasodilation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "isolated guinea pig heart", "subitem_subject_scheme": "Other"}, {"subitem_subject": "K^+ \u30c1\u30e3\u30cd\u30eb\u958b\u53e3\u85ac", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u5185\u76ae\u7531\u6765\u62e1\u5f35\u56e0\u5b50", "subitem_subject_scheme": "Other"}, {"subitem_subject": "L-\u30cb\u30c8\u30ed\u30a2\u30eb\u30ae\u30cb\u30f3", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u51a0\u8840\u7ba1\u62e1\u5f35", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30e2\u30eb\u30e2\u30c3\u30c8\u6458\u51fa\u5fc3", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u30e2\u30eb\u30e2\u30c3\u30c8\u704c\u6d41\u5fc3\u306b\u304a\u3051\u308bnicorandil\u304a\u3088\u3073cromakalim\u306e\u51a0\u6d41\u91cf\u5897\u52a0\u4f5c\u7528\u306b\u304a\u3088\u307c\u3059L-nitroarginine\u306e\u5f71\u97ff\u306b\u3064\u3044\u3066", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u30e2\u30eb\u30e2\u30c3\u30c8\u704c\u6d41\u5fc3\u306b\u304a\u3051\u308bnicorandil\u304a\u3088\u3073cromakalim\u306e\u51a0\u6d41\u91cf\u5897\u52a0\u4f5c\u7528\u306b\u304a\u3088\u307c\u3059L-nitroarginine\u306e\u5f71\u97ff\u306b\u3064\u3044\u3066"}, {"subitem_title": "\u30e2\u30eb\u30e2\u30c3\u30c8\u704c\u6d41\u5fc3\u306b\u304a\u3051\u308bnicorandil\u304a\u3088\u3073cromakalim\u306e\u51a0\u6d41\u91cf\u5897\u52a0\u4f5c\u7528\u306b\u304a\u3088\u307c\u3059L-nitroarginine\u306e\u5f71\u97ff\u306b\u3064\u3044\u3066", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1118"], "permalink_uri": "http://hdl.handle.net/10191/45157", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2016-12-21"}, "publish_date": "2016-12-21", "publish_status": "0", "recid": "17289", "relation": {}, "relation_version_is_last": true, "title": ["\u30e2\u30eb\u30e2\u30c3\u30c8\u704c\u6d41\u5fc3\u306b\u304a\u3051\u308bnicorandil\u304a\u3088\u3073cromakalim\u306e\u51a0\u6d41\u91cf\u5897\u52a0\u4f5c\u7528\u306b\u304a\u3088\u307c\u3059L-nitroarginine\u306e\u5f71\u97ff\u306b\u3064\u3044\u3066"], "weko_shared_id": null}