@article{oai:niigata-u.repo.nii.ac.jp:00017289,
 author = {神, 裕雅},
 issue = {7},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Jul},
 note = {Possible contribution of endothelium-derived relaxing factor (EDRF) to nicorandil- and cromakalim-induced coronary vasodilations was studied in isolated guinea pig hearts. Increases in coronary flow induced by nicorandil, cromakalim and adenosine were significantly inhibited by pretreatment with glibenclamide, an antagonist of ATP sensitive K^+ channel, while those by acetylcholine and papaverine were not. Pretreatment with L-nitroarginine(L-NA), an inhibitor of constitutive nitric oxide synthetase, or with methylene blue (MB), an inhibitor of guanylate cyclase, resulted in a significant inhibition of nicorandil-, cromakalim-, acetylcholine- and adenosine-induced increases in coronary flow. Papaverine-induced increase was not affected by pretreatment with L-NA or MB. These results suggest that the release of EDRF from vascular endothelium is responsible in part for coronary vasodilation induced by nicorandil and cromakalim.},
 pages = {452--459},
 title = {モルモット灌流心におけるnicorandilおよびcromakalimの冠流量増加作用におよぼすL-nitroarginineの影響について},
 volume = {111},
 year = {1997}
}