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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第111巻第9号

造血器腫瘍におけるTCL1遺伝子の発現

http://hdl.handle.net/10191/45292
http://hdl.handle.net/10191/45292
a3f8dd46-4d2d-4423-a449-067ee1103252
名前 / ファイル ライセンス アクション
111(9)_547-555.pdf 111(9)_547-555.pdf (1.8 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2017-01-06
タイトル
タイトル 造血器腫瘍におけるTCL1遺伝子の発現
タイトル
言語 en
タイトル 造血器腫瘍におけるTCL1遺伝子の発現
言語
言語 jpn
キーワード
主題Scheme Other
主題 hematopoietic malignancies
キーワード
主題Scheme Other
主題 adult T-cell leukemia (ATL)
キーワード
主題Scheme Other
主題 TCL1 gene
キーワード
主題Scheme Other
主題 chromosomal translocation
キーワード
主題Scheme Other
主題 造血器悪性腫瘍
キーワード
主題Scheme Other
主題 成人T細胞白血病
キーワード
主題Scheme Other
主題 TCL1 遺伝子
キーワード
主題Scheme Other
主題 染色体転座
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル TCL1 Gene Expression in Hematopoietic Malignancies
著者 瀧澤, 淳

× 瀧澤, 淳

WEKO 108076

瀧澤, 淳

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著者別名
識別子 108077
識別子Scheme WEKO
姓名 Takizawa, Jun
抄録
内容記述タイプ Abstract
内容記述 Adult T-cell leukemia (ATL) is recognized as an HTLV-1 associated T-cell malignancy. However, the genetic events involved in leukemogenesis of ATL remain to be clarified. Chromosome translocation involved 14q32 has been reported to be the most frequent in patients with ATL. Recently TCL1 gene at 14q32.1 was isolated as a candidate gene activated in T-cell malignancies. We, therefore, examined the expression of TCL1 gene in the blood samples from the patients with ATL, various cell lines and normal human tissues using the Northern blot analysis. In normal human tissues, TCL1 gene expression was detected in spleen, lymph nodes and B-lymphocytes of peripheral blood. The signal was not found in various samples from all 20 ATL patients but one. Cell lines of T-cell and myeloid lineages have no signal of TCL1. B-cell lines with various differentiation except for myeloma express TCL1 gene. These data suggest that TCL1 gene is not the major target gene involved in leukemogenesis of ATL and rather is involved in B-cell differentiation.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 111, 号 9, p. 547-555, 発行日 1997-09
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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