@article{oai:niigata-u.repo.nii.ac.jp:00017079,
 author = {瀧澤, 淳},
 issue = {9},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Sep},
 note = {Adult T-cell leukemia (ATL) is recognized as an HTLV-1 associated T-cell malignancy. However, the genetic events involved in leukemogenesis of ATL remain to be clarified. Chromosome translocation involved 14q32 has been reported to be the most frequent in patients with ATL. Recently TCL1 gene at 14q32.1 was isolated as a candidate gene activated in T-cell malignancies. We, therefore, examined the expression of TCL1 gene in the blood samples from the patients with ATL, various cell lines and normal human tissues using the Northern blot analysis. In normal human tissues, TCL1 gene expression was detected in spleen, lymph nodes and B-lymphocytes of peripheral blood. The signal was not found in various samples from all 20 ATL patients but one. Cell lines of T-cell and myeloid lineages have no signal of TCL1. B-cell lines with various differentiation except for myeloma express TCL1 gene. These data suggest that TCL1 gene is not the major target gene involved in leukemogenesis of ATL and rather is involved in B-cell differentiation.},
 pages = {547--555},
 title = {造血器腫瘍におけるTCL1遺伝子の発現},
 volume = {111},
 year = {1997}
}