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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第112巻第4号

甲状腺ホルモンによるラット心筋の電位依存性カリウムチャネル遺伝子発現の制御

http://hdl.handle.net/10191/45805
http://hdl.handle.net/10191/45805
9877d577-3c32-4569-8793-995b92947183
名前 / ファイル ライセンス アクション
112(4)_199-208.pdf 112(4)_199-208.pdf (2.0 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2017-01-26
タイトル
タイトル 甲状腺ホルモンによるラット心筋の電位依存性カリウムチャネル遺伝子発現の制御
タイトル
言語 en
タイトル 甲状腺ホルモンによるラット心筋の電位依存性カリウムチャネル遺伝子発現の制御
言語
言語 jpn
キーワード
主題Scheme Other
主題 potassium channel
キーワード
主題Scheme Other
主題 thyroid hormone
キーワード
主題Scheme Other
主題 T3 receptor
キーワード
主題Scheme Other
主題 カリウムイオンチャネル
キーワード
主題Scheme Other
主題 甲状腺ホルモン
キーワード
主題Scheme Other
主題 T3受容体
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Regulation of Voltage-Gated K^+ Channel mRNA Expression by Thyroid Hormone in Rat Ventricle
著者 阿部, 晃

× 阿部, 晃

WEKO 106532

阿部, 晃

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著者別名
識別子 106533
識別子Scheme WEKO
姓名 Abe, Akira
抄録
内容記述タイプ Abstract
内容記述 Since effects of thyroid hormones on cardiac function or rhythm has been shown, wheater triiodethyronine (T3) modulates voltage-gated potassium channel gene expression in rat heart or not was studied in the present study. The mRNA expression of five K^+ channel subunits (kv 1.2, kv 1.4, kv 1.5, kv 2.1 and kv 4.2) in rat ventricle was examined by RNase protection assay in rat which were treated with T3 or propylthyouracil (PTU) and was compared with control rats. Kv 1.2 mRNA expression strongly decreased in the ventricles of T3-treated rats, whereas Kv 1.5 mRNA increased, comparing to control rat ventricles. In contrast, Kv 1.5 mRNA expression in the ventricles strongly decreased and Kv 1.2 mRNA expression increased in PTU-treated rats. Interestingly, Kv 1.4 mRNA expression in ventricle was obviously enhanced by PTU-treatment although it was hardly detectable in control or T3-treated rat ventricles. The down-regulation of the ventricular Kv 1.5 mRNA expression by PTU was restored by administration of T3. No changes of Kv 2.1 and Kv 4.2 mRNA expression in ventricles were observed by the T3 or PTU treatment. These findings suggest that thyroid hormone influences mRNA expression of Shaker-related potassium channel genes (Kv 1.2, Kv 1.4 and Kv 1.5) in rat heart through T3 receptormediated regulation at a transcriptional level by an individually different direction.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 112, 号 4, p. 199-208, 発行日 1998-04
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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