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甲状腺ホルモンによるラット心筋の電位依存性カリウムチャネル遺伝子発現の制御
http://hdl.handle.net/10191/45805
http://hdl.handle.net/10191/458059877d577-3c32-4569-8793-995b92947183
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2017-01-26 | |||||
タイトル | ||||||
タイトル | 甲状腺ホルモンによるラット心筋の電位依存性カリウムチャネル遺伝子発現の制御 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 甲状腺ホルモンによるラット心筋の電位依存性カリウムチャネル遺伝子発現の制御 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | potassium channel | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | thyroid hormone | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | T3 receptor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | カリウムイオンチャネル | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 甲状腺ホルモン | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | T3受容体 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Regulation of Voltage-Gated K^+ Channel mRNA Expression by Thyroid Hormone in Rat Ventricle | |||||
著者 |
阿部, 晃
× 阿部, 晃 |
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著者別名 | ||||||
識別子 | 106533 | |||||
識別子Scheme | WEKO | |||||
姓名 | Abe, Akira | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Since effects of thyroid hormones on cardiac function or rhythm has been shown, wheater triiodethyronine (T3) modulates voltage-gated potassium channel gene expression in rat heart or not was studied in the present study. The mRNA expression of five K^+ channel subunits (kv 1.2, kv 1.4, kv 1.5, kv 2.1 and kv 4.2) in rat ventricle was examined by RNase protection assay in rat which were treated with T3 or propylthyouracil (PTU) and was compared with control rats. Kv 1.2 mRNA expression strongly decreased in the ventricles of T3-treated rats, whereas Kv 1.5 mRNA increased, comparing to control rat ventricles. In contrast, Kv 1.5 mRNA expression in the ventricles strongly decreased and Kv 1.2 mRNA expression increased in PTU-treated rats. Interestingly, Kv 1.4 mRNA expression in ventricle was obviously enhanced by PTU-treatment although it was hardly detectable in control or T3-treated rat ventricles. The down-regulation of the ventricular Kv 1.5 mRNA expression by PTU was restored by administration of T3. No changes of Kv 2.1 and Kv 4.2 mRNA expression in ventricles were observed by the T3 or PTU treatment. These findings suggest that thyroid hormone influences mRNA expression of Shaker-related potassium channel genes (Kv 1.2, Kv 1.4 and Kv 1.5) in rat heart through T3 receptormediated regulation at a transcriptional level by an individually different direction. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 112, 号 4, p. 199-208, 発行日 1998-04 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |