@article{oai:niigata-u.repo.nii.ac.jp:00016795,
 author = {阿部, 晃},
 issue = {4},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Apr},
 note = {Since effects of thyroid hormones on cardiac function or rhythm has been shown, wheater triiodethyronine (T3) modulates voltage-gated potassium channel gene expression in rat heart or not was studied in the present study. The mRNA expression of five K^+ channel subunits (kv 1.2, kv 1.4, kv 1.5, kv 2.1 and kv 4.2) in rat ventricle was examined by RNase protection assay in rat which were treated with T3 or propylthyouracil (PTU) and was compared with control rats. Kv 1.2 mRNA expression strongly decreased in the ventricles of T3-treated rats, whereas Kv 1.5 mRNA increased, comparing to control rat ventricles. In contrast, Kv 1.5 mRNA expression in the ventricles strongly decreased and Kv 1.2 mRNA expression increased in PTU-treated rats. Interestingly, Kv 1.4 mRNA expression in ventricle was obviously enhanced by PTU-treatment although it was hardly detectable in control or T3-treated rat ventricles. The down-regulation of the ventricular Kv 1.5 mRNA expression by PTU was restored by administration of T3. No changes of Kv 2.1 and Kv 4.2 mRNA expression in ventricles were observed by the T3 or PTU treatment. These findings suggest that thyroid hormone influences mRNA expression of Shaker-related potassium channel genes (Kv 1.2, Kv 1.4 and Kv 1.5) in rat heart through T3 receptormediated regulation at a transcriptional level by an individually different direction.},
 pages = {199--208},
 title = {甲状腺ホルモンによるラット心筋の電位依存性カリウムチャネル遺伝子発現の制御},
 volume = {112},
 year = {1998}
}