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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第112巻第5号

ワクシニアウイルスの膜蛋白による感染細胞のアポトーシスの誘導

http://hdl.handle.net/10191/45838
http://hdl.handle.net/10191/45838
b8824152-7b68-4149-96f1-4341135ba70f
名前 / ファイル ライセンス アクション
112(5)_263-269.pdf 112(5)_263-269.pdf (1.4 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2017-01-30
タイトル
タイトル ワクシニアウイルスの膜蛋白による感染細胞のアポトーシスの誘導
タイトル
言語 en
タイトル ワクシニアウイルスの膜蛋白による感染細胞のアポトーシスの誘導
言語
言語 jpn
キーワード
主題Scheme Other
主題 Waccinia virus
キーワード
主題Scheme Other
主題 Apoptosis
キーワード
主題Scheme Other
主題 TNF-α
キーワード
主題Scheme Other
主題 ワクシニアウイルス
キーワード
主題Scheme Other
主題 アポトーシス
キーワード
主題Scheme Other
主題 腫瘍壊死因子-α
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Apoptosis Induction by Penetration Protein of Vaccinia Virus
著者 林, 靖子

× 林, 靖子

WEKO 106140

林, 靖子

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著者別名
識別子 106141
識別子Scheme WEKO
姓名 Hayashi, Yasuko
抄録
内容記述タイプ Abstract
内容記述 Treatment with SDS-soluble fraction (vSF) of vaccinia virus induced apoptosis of U937 cells. Neutralizing 2D5mAb did not block the vSF-induced apoptosis, though removal of 2D5mAb-reactive VP23-29K deleted the apoptosis inducing capacity of the vSF, and affinity purified VP23-29K induced the apoptosis. The apoptosis inducer was the VP23-29K (LIR encoded penetration protein). The N-terminal amino acid sequence of the VP23-29K resembled to active site of hTNF-α. An anti-TNF receptor antibody, which inhibits TNF-induced apoptosis, did not inhibit the vSF-induced apoptosis. The vSF, hTNF-α and anti-TNF receptor mAb did not affect on adsorption, penetration and plaque formation of the virus. Moreover, the TNF-like sequence was suggested to orient inward on the virus by analogy to 3D structure of TNF/TNF-receptor. These results indicated that the TNF-αreceptor was not the virus receptor. The VP23-29K induces the apoptosis by an unique process, or the interaction between the VP23-29K and its unidentified receptor for penetration exposes the TNF-like sequence of VP23-29K to interact with host TNF-receptor.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 112, 号 5, p. 263-269, 発行日 1998-05
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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