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Neutralizing 2D5mAb did not block the vSF-induced apoptosis, though removal of 2D5mAb-reactive VP23-29K deleted the apoptosis inducing capacity of the vSF, and affinity purified VP23-29K induced the apoptosis. The apoptosis inducer was the VP23-29K (LIR encoded penetration protein). The N-terminal amino acid sequence of the VP23-29K resembled to active site of hTNF-\u03b1. An anti-TNF receptor antibody, which inhibits TNF-induced apoptosis, did not inhibit the vSF-induced apoptosis. The vSF, hTNF-\u03b1 and anti-TNF receptor mAb did not affect on adsorption, penetration and plaque formation of the virus. Moreover, the TNF-like sequence was suggested to orient inward on the virus by analogy to 3D structure of TNF/TNF-receptor. These results indicated that the TNF-\u03b1receptor was not the virus receptor. The VP23-29K induces the apoptosis by an unique process, or the interaction between the VP23-29K and its unidentified receptor for penetration exposes the TNF-like sequence of VP23-29K to interact with host TNF-receptor.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "106141", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Hayashi, Yasuko"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u6797, \u9756\u5b50"}], "nameIdentifiers": [{"nameIdentifier": "106140", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "112(5)_263-269.pdf", "filesize": [{"value": "1.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1400000.0, "url": {"label": "112(5)_263-269.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/16728/files/112(5)_263-269.pdf"}, "version_id": "11239e35-6dde-46f4-991f-a8e0399095a1"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Waccinia virus", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Apoptosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "TNF-\u03b1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30ef\u30af\u30b7\u30cb\u30a2\u30a6\u30a4\u30eb\u30b9", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u816b\u760d\u58ca\u6b7b\u56e0\u5b50-\u03b1", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u30ef\u30af\u30b7\u30cb\u30a2\u30a6\u30a4\u30eb\u30b9\u306e\u819c\u86cb\u767d\u306b\u3088\u308b\u611f\u67d3\u7d30\u80de\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306e\u8a98\u5c0e", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u30ef\u30af\u30b7\u30cb\u30a2\u30a6\u30a4\u30eb\u30b9\u306e\u819c\u86cb\u767d\u306b\u3088\u308b\u611f\u67d3\u7d30\u80de\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306e\u8a98\u5c0e"}, {"subitem_title": "\u30ef\u30af\u30b7\u30cb\u30a2\u30a6\u30a4\u30eb\u30b9\u306e\u819c\u86cb\u767d\u306b\u3088\u308b\u611f\u67d3\u7d30\u80de\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306e\u8a98\u5c0e", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1108"], "permalink_uri": "http://hdl.handle.net/10191/45838", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2017-01-30"}, "publish_date": "2017-01-30", "publish_status": "0", "recid": "16728", "relation": {}, "relation_version_is_last": true, "title": ["\u30ef\u30af\u30b7\u30cb\u30a2\u30a6\u30a4\u30eb\u30b9\u306e\u819c\u86cb\u767d\u306b\u3088\u308b\u611f\u67d3\u7d30\u80de\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306e\u8a98\u5c0e"], "weko_shared_id": null}