{"_buckets": {"deposit": "4f2fbeb6-99a3-4701-9e88-4f58d4cbaefc"}, "_deposit": {"id": "16728", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "16728"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00016728", "sets": ["456", "1108"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Apoptosis Induction by Penetration Protein of Vaccinia Virus"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1998-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "269", "bibliographicPageStart": "263", "bibliographicVolumeNumber": "112", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Treatment with SDS-soluble fraction (vSF) of vaccinia virus induced apoptosis of U937 cells. Neutralizing 2D5mAb did not block the vSF-induced apoptosis, though removal of 2D5mAb-reactive VP23-29K deleted the apoptosis inducing capacity of the vSF, and affinity purified VP23-29K induced the apoptosis. The apoptosis inducer was the VP23-29K (LIR encoded penetration protein). The N-terminal amino acid sequence of the VP23-29K resembled to active site of hTNF-α. An anti-TNF receptor antibody, which inhibits TNF-induced apoptosis, did not inhibit the vSF-induced apoptosis. The vSF, hTNF-α and anti-TNF receptor mAb did not affect on adsorption, penetration and plaque formation of the virus. Moreover, the TNF-like sequence was suggested to orient inward on the virus by analogy to 3D structure of TNF/TNF-receptor. These results indicated that the TNF-αreceptor was not the virus receptor. The VP23-29K induces the apoptosis by an unique process, or the interaction between the VP23-29K and its unidentified receptor for penetration exposes the TNF-like sequence of VP23-29K to interact with host TNF-receptor.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "106141", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Hayashi, Yasuko"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "林, 靖子"}], "nameIdentifiers": [{"nameIdentifier": "106140", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "112(5)_263-269.pdf", "filesize": [{"value": "1.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1400000.0, "url": {"label": "112(5)_263-269.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/16728/files/112(5)_263-269.pdf"}, "version_id": "11239e35-6dde-46f4-991f-a8e0399095a1"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Waccinia virus", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Apoptosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "TNF-α", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ワクシニアウイルス", "subitem_subject_scheme": "Other"}, {"subitem_subject": "アポトーシス", "subitem_subject_scheme": "Other"}, {"subitem_subject": "腫瘍壊死因子-α", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "ワクシニアウイルスの膜蛋白による感染細胞のアポトーシスの誘導", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "ワクシニアウイルスの膜蛋白による感染細胞のアポトーシスの誘導"}, {"subitem_title": "ワクシニアウイルスの膜蛋白による感染細胞のアポトーシスの誘導", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1108"], "permalink_uri": "http://hdl.handle.net/10191/45838", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-01-30"}, "publish_date": "2017-01-30", "publish_status": "0", "recid": "16728", "relation": {}, "relation_version_is_last": true, "title": ["ワクシニアウイルスの膜蛋白による感染細胞のアポトーシスの誘導"], "weko_shared_id": null}