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ワクシニアウイルスの膜蛋白による感染細胞のアポトーシスの誘導
http://hdl.handle.net/10191/45838
b8824152-7b68-4149-96f1-4341135ba70f
名前 / ファイル | ライセンス | アクション | |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2017-01-30 | |||||
タイトル | ||||||
タイトル | ワクシニアウイルスの膜蛋白による感染細胞のアポトーシスの誘導 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | ワクシニアウイルスの膜蛋白による感染細胞のアポトーシスの誘導 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Waccinia virus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Apoptosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | TNF-α | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ワクシニアウイルス | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | アポトーシス | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 腫瘍壊死因子-α | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Apoptosis Induction by Penetration Protein of Vaccinia Virus | |||||
著者 |
林, 靖子
× 林, 靖子 |
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著者別名 | ||||||
識別子 | ||||||
識別子 | 106141 | |||||
識別子Scheme | WEKO | |||||
姓名 | ||||||
姓名 | Hayashi, Yasuko | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Treatment with SDS-soluble fraction (vSF) of vaccinia virus induced apoptosis of U937 cells. Neutralizing 2D5mAb did not block the vSF-induced apoptosis, though removal of 2D5mAb-reactive VP23-29K deleted the apoptosis inducing capacity of the vSF, and affinity purified VP23-29K induced the apoptosis. The apoptosis inducer was the VP23-29K (LIR encoded penetration protein). The N-terminal amino acid sequence of the VP23-29K resembled to active site of hTNF-α. An anti-TNF receptor antibody, which inhibits TNF-induced apoptosis, did not inhibit the vSF-induced apoptosis. The vSF, hTNF-α and anti-TNF receptor mAb did not affect on adsorption, penetration and plaque formation of the virus. Moreover, the TNF-like sequence was suggested to orient inward on the virus by analogy to 3D structure of TNF/TNF-receptor. These results indicated that the TNF-αreceptor was not the virus receptor. The VP23-29K induces the apoptosis by an unique process, or the interaction between the VP23-29K and its unidentified receptor for penetration exposes the TNF-like sequence of VP23-29K to interact with host TNF-receptor. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 112, 号 5, p. 263-269, 発行日 1998-05 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |