{"created":"2021-03-01T06:21:20.742928+00:00","id":16728,"links":{},"metadata":{"_buckets":{"deposit":"4f2fbeb6-99a3-4701-9e88-4f58d4cbaefc"},"_deposit":{"id":"16728","owners":[],"pid":{"revision_id":0,"type":"depid","value":"16728"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00016728","sets":["453:456","471:537:538:1108"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Apoptosis Induction by Penetration Protein of Vaccinia Virus"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1998-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"269","bibliographicPageStart":"263","bibliographicVolumeNumber":"112","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Treatment with SDS-soluble fraction (vSF) of vaccinia virus induced apoptosis of U937 cells. Neutralizing 2D5mAb did not block the vSF-induced apoptosis, though removal of 2D5mAb-reactive VP23-29K deleted the apoptosis inducing capacity of the vSF, and affinity purified VP23-29K induced the apoptosis. The apoptosis inducer was the VP23-29K (LIR encoded penetration protein). The N-terminal amino acid sequence of the VP23-29K resembled to active site of hTNF-α. An anti-TNF receptor antibody, which inhibits TNF-induced apoptosis, did not inhibit the vSF-induced apoptosis. The vSF, hTNF-α and anti-TNF receptor mAb did not affect on adsorption, penetration and plaque formation of the virus. Moreover, the TNF-like sequence was suggested to orient inward on the virus by analogy to 3D structure of TNF/TNF-receptor. These results indicated that the TNF-αreceptor was not the virus receptor. The VP23-29K induces the apoptosis by an unique process, or the interaction between the VP23-29K and its unidentified receptor for penetration exposes the TNF-like sequence of VP23-29K to interact with host TNF-receptor.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"106141","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Hayashi, Yasuko"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"林, 靖子"}],"nameIdentifiers":[{"nameIdentifier":"106140","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-07"}],"displaytype":"detail","filename":"112(5)_263-269.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"112(5)_263-269.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/16728/files/112(5)_263-269.pdf"},"version_id":"11239e35-6dde-46f4-991f-a8e0399095a1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Waccinia virus","subitem_subject_scheme":"Other"},{"subitem_subject":"Apoptosis","subitem_subject_scheme":"Other"},{"subitem_subject":"TNF-α","subitem_subject_scheme":"Other"},{"subitem_subject":"ワクシニアウイルス","subitem_subject_scheme":"Other"},{"subitem_subject":"アポトーシス","subitem_subject_scheme":"Other"},{"subitem_subject":"腫瘍壊死因子-α","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ワクシニアウイルスの膜蛋白による感染細胞のアポトーシスの誘導","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ワクシニアウイルスの膜蛋白による感染細胞のアポトーシスの誘導"},{"subitem_title":"ワクシニアウイルスの膜蛋白による感染細胞のアポトーシスの誘導","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1108"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-01-30"},"publish_date":"2017-01-30","publish_status":"0","recid":"16728","relation_version_is_last":true,"title":["ワクシニアウイルスの膜蛋白による感染細胞のアポトーシスの誘導"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:48:13.603404+00:00"}