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Identification of myo-inositol hexakisphosphate (IP6) as a β-secretase 1 (BACE 1) inhibitory molecule in rice grain extract and digest
http://hdl.handle.net/10191/30171
http://hdl.handle.net/10191/3017191cf5a85-8666-4661-b62a-5be6779ef9f9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
4_162-167.pdf (877.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-11-12 | |||||
| タイトル | ||||||
| タイトル | Identification of myo-inositol hexakisphosphate (IP6) as a β-secretase 1 (BACE 1) inhibitory molecule in rice grain extract and digest | |||||
| タイトル | ||||||
| タイトル | Identification of myo-inositol hexakisphosphate (IP6) as a β-secretase 1 (BACE 1) inhibitory molecule in rice grain extract and digest | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Alzheimer’s disease | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Aβ | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | BACE1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Rice grain | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | IP6 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | SH-SY5Y cells | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Abe, Takako K.
× Abe, Takako K.× Taniguchi, Masayuki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Alzheimer’s disease (AD) is widely considered to be caused by amyloid-β peptide (Aβ) accumulation in the brain. Aβ is excised from amyloid-β precursor protein through sequential cleavage by β-secretase 1 (BACE1) and γ-secretase. Thus, BACE1 inhibition could prevent Aβ accumulation. Here, we identified myo-inositol hexakisphosphate (IP6) as a BACE1 inhibitory molecule in rice grain extract and digest. The rice digest and IP6 significantly inhibited Aβ production in neuroblastoma cells without cytotoxicity. These results suggested that rice components, including IP6, may be promising starting materials for the development of potent and safe drugs and/or food to prevent AD. | |||||
| 書誌情報 |
FEBS Open Bio en : FEBS Open Bio 巻 4, p. 162-167, 発行日 2014-01 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 22115463 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1016/j.fob.2014.01.008 | |||||
| 権利 | ||||||
| 権利情報 | Copyright(C) 2014 The Authors. Published by Elsevier B.V. | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
