{"created":"2021-03-01T06:05:19.787451+00:00","id":1657,"links":{},"metadata":{"_buckets":{"deposit":"7e12746a-6865-43a6-ab94-2774ee9d9ae7"},"_deposit":{"id":"1657","owners":[],"pid":{"revision_id":0,"type":"depid","value":"1657"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00001657","sets":["423:424:425","453:454"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"167","bibliographicPageStart":"162","bibliographicVolumeNumber":"4","bibliographic_titles":[{"bibliographic_title":"FEBS Open Bio"},{"bibliographic_title":"FEBS Open Bio","bibliographic_titleLang":"en"}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Alzheimer’s disease (AD) is widely considered to be caused by amyloid-β peptide (Aβ) accumulation in the brain. Aβ is excised from amyloid-β precursor protein through sequential cleavage by β-secretase 1 (BACE1) and γ-secretase. Thus, BACE1 inhibition could prevent Aβ accumulation. Here, we identified myo-inositol hexakisphosphate (IP6) as a BACE1 inhibitory molecule in rice grain extract and digest. The rice digest and IP6 significantly inhibited Aβ production in neuroblastoma cells without cytotoxicity. These results suggested that rice components, including IP6, may be promising starting materials for the development of potent and safe drugs and/or food to prevent AD.","subitem_description_type":"Abstract"}]},"item_5_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_5_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1016/j.fob.2014.01.008","subitem_relation_type_select":"DOI"}}]},"item_5_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright(C) 2014 The Authors. Published by Elsevier B.V."}]},"item_5_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_5_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"22115463","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Abe, Takako K."}],"nameIdentifiers":[{"nameIdentifier":"4849","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Taniguchi, Masayuki"}],"nameIdentifiers":[{"nameIdentifier":"4850","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-29"}],"displaytype":"detail","filename":"4_162-167.pdf","filesize":[{"value":"877.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"4_162-167.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/1657/files/4_162-167.pdf"},"version_id":"a4bdbddf-dd9b-49e0-850a-8e8a733338c7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Alzheimer’s disease","subitem_subject_scheme":"Other"},{"subitem_subject":"Aβ","subitem_subject_scheme":"Other"},{"subitem_subject":"BACE1","subitem_subject_scheme":"Other"},{"subitem_subject":"Rice grain","subitem_subject_scheme":"Other"},{"subitem_subject":"IP6","subitem_subject_scheme":"Other"},{"subitem_subject":"SH-SY5Y cells","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Identification of myo-inositol hexakisphosphate (IP6) as a β-secretase 1 (BACE 1) inhibitory molecule in rice grain extract and digest","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Identification of myo-inositol hexakisphosphate (IP6) as a β-secretase 1 (BACE 1) inhibitory molecule in rice grain extract and digest"},{"subitem_title":"Identification of myo-inositol hexakisphosphate (IP6) as a β-secretase 1 (BACE 1) inhibitory molecule in rice grain extract and digest","subitem_title_language":"en"}]},"item_type_id":"5","owner":"1","path":["454","425"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-11-12"},"publish_date":"2014-11-12","publish_status":"0","recid":"1657","relation_version_is_last":true,"title":["Identification of myo-inositol hexakisphosphate (IP6) as a β-secretase 1 (BACE 1) inhibitory molecule in rice grain extract and digest"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:34:19.286656+00:00"}