{"_buckets": {"deposit": "9603de1d-02fc-4c7a-8f96-21f7fb245976"}, "_deposit": {"id": "1646", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "1646"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00001646", "sets": []}, "author_link": ["4769", "4770", "4771", "4772", "4773", "4774", "4775", "4776", "4777", "4778", "4779", "4780", "4781", "4782", "4783", "4784", "4785", "4786"], "control_number": "1646", "item_5_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2005-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6", "bibliographicPageEnd": "2005", "bibliographicPageStart": "1995", "bibliographicVolumeNumber": "35", "bibliographic_titles": [{"bibliographic_title": "European journal of immunology"}, {"bibliographic_title": "European journal of immunology", "bibliographic_titleLang": "en"}]}]}, "item_5_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Interleukin (IL)-13 is a pleiotropic cytokine secreted by activated Th2-T lymphocytes. Th1 cytokines are assumed to exacerbate while Th2 cytokines to ameliorate rat experimental autoimmune myocarditis (EAM). Here, we examined the effect of IL-13 on EAM using a hydrodynamic-based delivery of an IL-13-Ig and the possible mechanism of its effect. Rats were immunized on day 0 and IL-13-Ig treated rats were injected with pCAGGS-IL-13-Ig and control rats with pCAGGS-Ig on day 1 or 7. On day 17, IL-13-Ig gene therapy was effective in controlling EAM as monitored by the decreased heart weight/body weight ratio, reduced myocarditis and atrial natriuretic peptide mRNA in heart as a heart failure marker. On the basis of IL-13 receptor mRNA expression in separated cells from EAM hearts, we proposed that IL-13-Ig targeting cells were CD11b+ cells and non-cardiomyocytic non-inflammatory (NCNI) cells such as fibroblasts, smooth muscle or endothelial cells. IL-13-Ig inhibited expressing the genes of prostaglandin E synthase, cyclooxygenase-2, inducible nitric oxide synthase, IL-1\u03b2 and TNF\u03b1 of cultivated cells from EAM hearts in contrast, while it enhanced IL-1 receptor antagonist. We concluded that IL-13-Ig ameliorates EAM and supposed that its effectiveness may be due to the influence on these immunologic molecules in CD11b+ and NCNI cells.", "subitem_description_type": "Abstract"}]}, "item_5_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "4786", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "\u5859, \u6674\u96c4"}]}]}, "item_5_relation_13": {"attribute_name": "PubMed\u756a\u53f7", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "15902684", "subitem_relation_type_select": "PMID"}}]}, "item_5_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1002/eji.200425776", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_15": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "WILEY-VCH Verlag GmbH \u0026 Co. KGaA, Weinheim"}]}, "item_5_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_5_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00639610", "subitem_source_identifier_type": "NCID"}]}, "item_5_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00142980", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Elnaggar, Raafat"}], "nameIdentifiers": [{"nameIdentifier": "4769", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hanawa, Haruo"}], "nameIdentifiers": [{"nameIdentifier": "4770", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Liu, Hui"}], "nameIdentifiers": [{"nameIdentifier": "4771", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshida, Tsuyoshi"}], "nameIdentifiers": [{"nameIdentifier": "4772", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hayashi, Manabu"}], "nameIdentifiers": [{"nameIdentifier": "4773", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Watanabe, Ritsuo"}], "nameIdentifiers": [{"nameIdentifier": "4774", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Abe, Satoru"}], "nameIdentifiers": [{"nameIdentifier": "4775", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Toba, Ken"}], "nameIdentifiers": [{"nameIdentifier": "4776", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshida, Kaori"}], "nameIdentifiers": [{"nameIdentifier": "4777", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Chang, He"}], "nameIdentifiers": [{"nameIdentifier": "4778", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Minagawa, Shiro"}], "nameIdentifiers": [{"nameIdentifier": "4779", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okura, Yuji"}], "nameIdentifiers": [{"nameIdentifier": "4780", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kato, Kiminori"}], "nameIdentifiers": [{"nameIdentifier": "4781", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kodama, Makoto"}], "nameIdentifiers": [{"nameIdentifier": "4782", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Maruyama, Hiroki"}], "nameIdentifiers": [{"nameIdentifier": "4783", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyazaki, Junichi"}], "nameIdentifiers": [{"nameIdentifier": "4784", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Aizawa, Yoshifusa"}], "nameIdentifiers": [{"nameIdentifier": "4785", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-07-29"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "22_0003.pdf", "filesize": [{"value": "605.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 605100.0, "url": {"label": "22_0003.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/1646/files/22_0003.pdf"}, "version_id": "995129b1-2e54-42a2-8af5-eeabc78ef8df"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "myocarditis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "autoimmune", "subitem_subject_scheme": "Other"}, {"subitem_subject": "dilated cardiomyopathy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "immune system", "subitem_subject_scheme": "Other"}, {"subitem_subject": "interleukin-13", "subitem_subject_scheme": "Other"}, {"subitem_subject": "gene therapy", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "The effect of hydrodynamic-based delivery of an interleukin-13-Ig fusion gene for experimental autoimmune myocarditis in rats and its possible mechanism", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "The effect of hydrodynamic-based delivery of an interleukin-13-Ig fusion gene for experimental autoimmune myocarditis in rats and its possible mechanism", "subitem_title_language": "en"}]}, "item_type_id": "5", "owner": "1", "path": ["453/454", "471/472/473"], "permalink_uri": "http://hdl.handle.net/10191/1159", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2007-04-23"}, "publish_date": "2007-04-23", "publish_status": "0", "recid": "1646", "relation": {}, "relation_version_is_last": true, "title": ["The effect of hydrodynamic-based delivery of an interleukin-13-Ig fusion gene for experimental autoimmune myocarditis in rats and its possible mechanism"], "weko_shared_id": -1}