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  1. 0 資料タイプ別
  2. 01 学術雑誌論文
  1. 250 大学院医歯学総合研究科(医)
  2. 10 学術雑誌論文
  3. 10 査読済論文

The effect of hydrodynamic-based delivery of an interleukin-13-Ig fusion gene for experimental autoimmune myocarditis in rats and its possible mechanism

http://hdl.handle.net/10191/1159
http://hdl.handle.net/10191/1159
a70f3548-4c5f-4138-94d2-584c3ed2b69a
名前 / ファイル ライセンス アクション
22_0003.pdf 22_0003.pdf (605.1 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2007-04-23
タイトル
言語 en
タイトル The effect of hydrodynamic-based delivery of an interleukin-13-Ig fusion gene for experimental autoimmune myocarditis in rats and its possible mechanism
言語
言語 eng
キーワード
主題Scheme Other
主題 myocarditis
キーワード
主題Scheme Other
主題 autoimmune
キーワード
主題Scheme Other
主題 dilated cardiomyopathy
キーワード
主題Scheme Other
主題 immune system
キーワード
主題Scheme Other
主題 interleukin-13
キーワード
主題Scheme Other
主題 gene therapy
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Elnaggar, Raafat

× Elnaggar, Raafat

WEKO 4769

Elnaggar, Raafat

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Hanawa, Haruo

× Hanawa, Haruo

WEKO 4770

Hanawa, Haruo

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Liu, Hui

× Liu, Hui

WEKO 4771

Liu, Hui

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Yoshida, Tsuyoshi

× Yoshida, Tsuyoshi

WEKO 4772

Yoshida, Tsuyoshi

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Hayashi, Manabu

× Hayashi, Manabu

WEKO 4773

Hayashi, Manabu

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Watanabe, Ritsuo

× Watanabe, Ritsuo

WEKO 4774

Watanabe, Ritsuo

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Abe, Satoru

× Abe, Satoru

WEKO 4775

Abe, Satoru

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Toba, Ken

× Toba, Ken

WEKO 4776

Toba, Ken

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Yoshida, Kaori

× Yoshida, Kaori

WEKO 4777

Yoshida, Kaori

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Chang, He

× Chang, He

WEKO 4778

Chang, He

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Minagawa, Shiro

× Minagawa, Shiro

WEKO 4779

Minagawa, Shiro

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Okura, Yuji

× Okura, Yuji

WEKO 4780

Okura, Yuji

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Kato, Kiminori

× Kato, Kiminori

WEKO 4781

Kato, Kiminori

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Kodama, Makoto

× Kodama, Makoto

WEKO 4782

Kodama, Makoto

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Maruyama, Hiroki

× Maruyama, Hiroki

WEKO 4783

Maruyama, Hiroki

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Miyazaki, Junichi

× Miyazaki, Junichi

WEKO 4784

Miyazaki, Junichi

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Aizawa, Yoshifusa

× Aizawa, Yoshifusa

WEKO 4785

Aizawa, Yoshifusa

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著者別名
識別子 4786
識別子Scheme WEKO
姓名 塙, 晴雄
抄録
内容記述タイプ Abstract
内容記述 Interleukin (IL)-13 is a pleiotropic cytokine secreted by activated Th2-T lymphocytes. Th1 cytokines are assumed to exacerbate while Th2 cytokines to ameliorate rat experimental autoimmune myocarditis (EAM). Here, we examined the effect of IL-13 on EAM using a hydrodynamic-based delivery of an IL-13-Ig and the possible mechanism of its effect. Rats were immunized on day 0 and IL-13-Ig treated rats were injected with pCAGGS-IL-13-Ig and control rats with pCAGGS-Ig on day 1 or 7. On day 17, IL-13-Ig gene therapy was effective in controlling EAM as monitored by the decreased heart weight/body weight ratio, reduced myocarditis and atrial natriuretic peptide mRNA in heart as a heart failure marker. On the basis of IL-13 receptor mRNA expression in separated cells from EAM hearts, we proposed that IL-13-Ig targeting cells were CD11b+ cells and non-cardiomyocytic non-inflammatory (NCNI) cells such as fibroblasts, smooth muscle or endothelial cells. IL-13-Ig inhibited expressing the genes of prostaglandin E synthase, cyclooxygenase-2, inducible nitric oxide synthase, IL-1β and TNFα of cultivated cells from EAM hearts in contrast, while it enhanced IL-1 receptor antagonist. We concluded that IL-13-Ig ameliorates EAM and supposed that its effectiveness may be due to the influence on these immunologic molecules in CD11b+ and NCNI cells.
書誌情報 European journal of immunology
en : European journal of immunology

巻 35, 号 6, p. 1995-2005, 発行日 2005-06
ISSN
収録物識別子タイプ ISSN
収録物識別子 00142980
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00639610
PubMed番号
識別子タイプ PMID
関連識別子 15902684
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1002/eji.200425776
権利
権利情報 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
著者版フラグ
値 author
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