{"created":"2021-03-01T06:05:19.111353+00:00","id":1646,"links":{},"metadata":{"_buckets":{"deposit":"9603de1d-02fc-4c7a-8f96-21f7fb245976"},"_deposit":{"id":"1646","owners":[],"pid":{"revision_id":0,"type":"depid","value":"1646"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00001646","sets":["453:454","471:472:473"]},"author_link":["4769","4770","4771","4772","4773","4774","4775","4776","4777","4778","4779","4780","4781","4782","4783","4784","4785","4786"],"control_number":"1646","item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"2005","bibliographicPageStart":"1995","bibliographicVolumeNumber":"35","bibliographic_titles":[{"bibliographic_title":"European journal of immunology"},{"bibliographic_title":"European journal of immunology","bibliographic_titleLang":"en"}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Interleukin (IL)-13 is a pleiotropic cytokine secreted by activated Th2-T lymphocytes. Th1 cytokines are assumed to exacerbate while Th2 cytokines to ameliorate rat experimental autoimmune myocarditis (EAM). Here, we examined the effect of IL-13 on EAM using a hydrodynamic-based delivery of an IL-13-Ig and the possible mechanism of its effect. Rats were immunized on day 0 and IL-13-Ig treated rats were injected with pCAGGS-IL-13-Ig and control rats with pCAGGS-Ig on day 1 or 7. On day 17, IL-13-Ig gene therapy was effective in controlling EAM as monitored by the decreased heart weight/body weight ratio, reduced myocarditis and atrial natriuretic peptide mRNA in heart as a heart failure marker. On the basis of IL-13 receptor mRNA expression in separated cells from EAM hearts, we proposed that IL-13-Ig targeting cells were CD11b+ cells and non-cardiomyocytic non-inflammatory (NCNI) cells such as fibroblasts, smooth muscle or endothelial cells. IL-13-Ig inhibited expressing the genes of prostaglandin E synthase, cyclooxygenase-2, inducible nitric oxide synthase, IL-1β and TNFα of cultivated cells from EAM hearts in contrast, while it enhanced IL-1 receptor antagonist. We concluded that IL-13-Ig ameliorates EAM and supposed that its effectiveness may be due to the influence on these immunologic molecules in CD11b+ and NCNI cells.","subitem_description_type":"Abstract"}]},"item_5_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"4786","nameIdentifierScheme":"WEKO"}],"names":[{"name":"塙, 晴雄"}]}]},"item_5_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"15902684","subitem_relation_type_select":"PMID"}}]},"item_5_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1002/eji.200425776","subitem_relation_type_select":"DOI"}}]},"item_5_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim"}]},"item_5_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_5_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00639610","subitem_source_identifier_type":"NCID"}]},"item_5_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00142980","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Elnaggar, Raafat"}],"nameIdentifiers":[{"nameIdentifier":"4769","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hanawa, Haruo"}],"nameIdentifiers":[{"nameIdentifier":"4770","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Liu, Hui"}],"nameIdentifiers":[{"nameIdentifier":"4771","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshida, Tsuyoshi"}],"nameIdentifiers":[{"nameIdentifier":"4772","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hayashi, Manabu"}],"nameIdentifiers":[{"nameIdentifier":"4773","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Ritsuo"}],"nameIdentifiers":[{"nameIdentifier":"4774","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Abe, Satoru"}],"nameIdentifiers":[{"nameIdentifier":"4775","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Toba, Ken"}],"nameIdentifiers":[{"nameIdentifier":"4776","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshida, Kaori"}],"nameIdentifiers":[{"nameIdentifier":"4777","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chang, He"}],"nameIdentifiers":[{"nameIdentifier":"4778","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Minagawa, Shiro"}],"nameIdentifiers":[{"nameIdentifier":"4779","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okura, Yuji"}],"nameIdentifiers":[{"nameIdentifier":"4780","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Kiminori"}],"nameIdentifiers":[{"nameIdentifier":"4781","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kodama, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"4782","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maruyama, Hiroki"}],"nameIdentifiers":[{"nameIdentifier":"4783","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyazaki, Junichi"}],"nameIdentifiers":[{"nameIdentifier":"4784","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aizawa, Yoshifusa"}],"nameIdentifiers":[{"nameIdentifier":"4785","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-29"}],"displaytype":"detail","filename":"22_0003.pdf","filesize":[{"value":"605.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"22_0003.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/1646/files/22_0003.pdf"},"version_id":"995129b1-2e54-42a2-8af5-eeabc78ef8df"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"myocarditis","subitem_subject_scheme":"Other"},{"subitem_subject":"autoimmune","subitem_subject_scheme":"Other"},{"subitem_subject":"dilated cardiomyopathy","subitem_subject_scheme":"Other"},{"subitem_subject":"immune system","subitem_subject_scheme":"Other"},{"subitem_subject":"interleukin-13","subitem_subject_scheme":"Other"},{"subitem_subject":"gene therapy","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The effect of hydrodynamic-based delivery of an interleukin-13-Ig fusion gene for experimental autoimmune myocarditis in rats and its possible mechanism","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The effect of hydrodynamic-based delivery of an interleukin-13-Ig fusion gene for experimental autoimmune myocarditis in rats and its possible mechanism","subitem_title_language":"en"}]},"item_type_id":"5","owner":"1","path":["454","473"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2007-04-23"},"publish_date":"2007-04-23","publish_status":"0","recid":"1646","relation_version_is_last":true,"title":["The effect of hydrodynamic-based delivery of an interleukin-13-Ig fusion gene for experimental autoimmune myocarditis in rats and its possible mechanism"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-15T04:14:16.363542+00:00"}