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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第112巻第10号

脊髄後角におけるオピオイドの選択的痛覚抑制

http://hdl.handle.net/10191/46257
http://hdl.handle.net/10191/46257
4527f8a1-ee6e-4466-81bd-aebe49bb3cc0
名前 / ファイル ライセンス アクション
112(10)_621-630.pdf 112(10)_621-630.pdf (1.6 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2017-02-08
タイトル
タイトル 脊髄後角におけるオピオイドの選択的痛覚抑制
タイトル
言語 en
タイトル 脊髄後角におけるオピオイドの選択的痛覚抑制
言語
言語 jpn
キーワード
主題Scheme Other
主題 substantia gelatinosa
キーワード
主題Scheme Other
主題 opioid receptor
キーワード
主題Scheme Other
主題 presynaptic inhibition
キーワード
主題Scheme Other
主題 antinociception
キーワード
主題Scheme Other
主題 spinal cord
キーワード
主題Scheme Other
主題 EPSC
キーワード
主題Scheme Other
主題 IPSC
キーワード
主題Scheme Other
主題 オピオイド
キーワード
主題Scheme Other
主題 脊髄痛覚抑制
キーワード
主題Scheme Other
主題 ホールセルパッチクランプ法
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Selective Inhibitory Action of Opioids on Excitatory Transmission in the Rat Spinal Dorsal Horn
著者 河野, 達郎

× 河野, 達郎

WEKO 104361

河野, 達郎

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著者別名
識別子 104362
識別子Scheme WEKO
姓名 Kohno, Tatsuro
抄録
内容記述タイプ Abstract
内容記述 Whole cell patch clamp recordings were made from substantia gelatinosa (SG) neurons in adult rat spinal cord slices to study the presynaptic mechanisms of opioid agonists on primary afferent transmission. Both μ receptor agonist (DAMGO, 1 μM) and a receptor agonist (DPDPE, 1μM) inhibited the amplitude of Aδ afferent fiberevoked excitatory postsynaptic currents (EPSCs) by 27 % and 17 %, respectively, DAMGO and DPDPE also suppressed the frequency of miniature EPSCs by 61 % and 23 %, respectively, without affecting amplitude distributions. The κ receptor agonist (U-69593, 1 μM), however, had little effect on both the evoked and miniature EPSCs. Neither DAMGO nor DPDPE affected the amplitude of postsypaptic currents produced by AMPA, suggesting a presynaptic site of action of these opioid receptor agonists. Evoked and miniature inhibitory postsynaptic currents (IPSCs) mediated by GABA_A or glycine receptor were not significantly affected by μ, δ and κ receptor agonists. These observations suggest that opioids, particularly through μ and δ receptors, predominantly suppress excitatory synaptic transmission by reducing glutamate release from primary afferent terminals. This presynaptic modulation of the sensory transmission might be a possible mechanism for antinociceptive effects produced by the intrathecal administration of opioid agonists.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 112, 号 10, p. 621-630, 発行日 1998-10
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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