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Both \u03bc receptor agonist (DAMGO, 1 \u03bcM) and a receptor agonist (DPDPE, 1\u03bcM) inhibited the amplitude of A\u03b4 afferent fiberevoked excitatory postsynaptic currents (EPSCs) by 27 % and 17 %, respectively, DAMGO and DPDPE also suppressed the frequency of miniature EPSCs by 61 % and 23 %, respectively, without affecting amplitude distributions. The \u03ba receptor agonist (U-69593, 1 \u03bcM), however, had little effect on both the evoked and miniature EPSCs. Neither DAMGO nor DPDPE affected the amplitude of postsypaptic currents produced by AMPA, suggesting a presynaptic site of action of these opioid receptor agonists. Evoked and miniature inhibitory postsynaptic currents (IPSCs) mediated by GABA_A or glycine receptor were not significantly affected by \u03bc, \u03b4 and \u03ba receptor agonists. These observations suggest that opioids, particularly through \u03bc and \u03b4 receptors, predominantly suppress excitatory synaptic transmission by reducing glutamate release from primary afferent terminals. This presynaptic modulation of the sensory transmission might be a possible mechanism for antinociceptive effects produced by the intrathecal administration of opioid agonists.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "104362", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kohno, Tatsuro"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u6cb3\u91ce, \u9054\u90ce"}], "nameIdentifiers": [{"nameIdentifier": "104361", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "112(10)_621-630.pdf", "filesize": [{"value": "1.6 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1600000.0, "url": {"label": "112(10)_621-630.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/16375/files/112(10)_621-630.pdf"}, "version_id": "2a4b7c6d-3417-4501-b7e1-e8ce280692f1"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "substantia gelatinosa", "subitem_subject_scheme": "Other"}, {"subitem_subject": "opioid receptor", "subitem_subject_scheme": "Other"}, {"subitem_subject": "presynaptic inhibition", "subitem_subject_scheme": "Other"}, {"subitem_subject": "antinociception", "subitem_subject_scheme": "Other"}, {"subitem_subject": "spinal cord", "subitem_subject_scheme": "Other"}, {"subitem_subject": "EPSC", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IPSC", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30aa\u30d4\u30aa\u30a4\u30c9", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u810a\u9ac4\u75db\u899a\u6291\u5236", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30db\u30fc\u30eb\u30bb\u30eb\u30d1\u30c3\u30c1\u30af\u30e9\u30f3\u30d7\u6cd5", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u810a\u9ac4\u5f8c\u89d2\u306b\u304a\u3051\u308b\u30aa\u30d4\u30aa\u30a4\u30c9\u306e\u9078\u629e\u7684\u75db\u899a\u6291\u5236", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u810a\u9ac4\u5f8c\u89d2\u306b\u304a\u3051\u308b\u30aa\u30d4\u30aa\u30a4\u30c9\u306e\u9078\u629e\u7684\u75db\u899a\u6291\u5236"}, {"subitem_title": "\u810a\u9ac4\u5f8c\u89d2\u306b\u304a\u3051\u308b\u30aa\u30d4\u30aa\u30a4\u30c9\u306e\u9078\u629e\u7684\u75db\u899a\u6291\u5236", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1103"], "permalink_uri": "http://hdl.handle.net/10191/46257", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2017-02-08"}, "publish_date": "2017-02-08", "publish_status": "0", "recid": "16375", "relation": {}, "relation_version_is_last": true, "title": ["\u810a\u9ac4\u5f8c\u89d2\u306b\u304a\u3051\u308b\u30aa\u30d4\u30aa\u30a4\u30c9\u306e\u9078\u629e\u7684\u75db\u899a\u6291\u5236"], "weko_shared_id": null}