@article{oai:niigata-u.repo.nii.ac.jp:00016375,
 author = {河野, 達郎},
 issue = {10},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Oct},
 note = {Whole cell patch clamp recordings were made from substantia gelatinosa (SG) neurons in adult rat spinal cord slices to study the presynaptic mechanisms of opioid agonists on primary afferent transmission. Both μ receptor agonist (DAMGO, 1 μM) and a receptor agonist (DPDPE, 1μM) inhibited the amplitude of Aδ afferent fiberevoked excitatory postsynaptic currents (EPSCs) by 27 % and 17 %, respectively, DAMGO and DPDPE also suppressed the frequency of miniature EPSCs by 61 % and 23 %, respectively, without affecting amplitude distributions. The κ receptor agonist (U-69593, 1 μM), however, had little effect on both the evoked and miniature EPSCs. Neither DAMGO nor DPDPE affected the amplitude of postsypaptic currents produced by AMPA, suggesting a presynaptic site of action of these opioid receptor agonists. Evoked and miniature inhibitory postsynaptic currents (IPSCs) mediated by GABA_A or glycine receptor were not significantly affected by μ, δ and κ receptor agonists. These observations suggest that opioids, particularly through μ and δ receptors, predominantly suppress excitatory synaptic transmission by reducing glutamate release from primary afferent terminals. This presynaptic modulation of the sensory transmission might be a possible mechanism for antinociceptive effects produced by the intrathecal administration of opioid agonists.},
 pages = {621--630},
 title = {脊髄後角におけるオピオイドの選択的痛覚抑制},
 volume = {112},
 year = {1998}
}