{"_buckets": {"deposit": "31f772c1-b481-45f3-9045-519290ebda26"}, "_deposit": {"id": "16298", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "16298"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00016298"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Bacteriological Approach to Sarcoidosis\uff1aDifference of Cytokine-inducing Ability in Various Strain of Propionibacterium Acnes"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1998-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "11", "bibliographicPageEnd": "684", "bibliographicPageStart": "680", "bibliographicVolumeNumber": "112", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Propionibacterium acnes has been implicated as the etiologic agent of sarcoidosis since the isolation of this bacterium at a high incidence from sarcoidosis specimens in 1978. However, this possibility has not been established or accepted widely yet. We have obtained the P. acnes strains isolated in that study. Based on the idea that inflammatory cytokines are involved in granuloma formation characteristic for pathology of sarcoidosis, we have compared the cytokine-inducing ability among various strains. \uff3bMethod\uff3d Peripheral blood mononuclear cells were obtained from sarcoidosis patients and healthy controls. Cells were stimulated with P. acnes strains in vitro, and inflammatory cytokines were determined by using cytokine-specific EIA. The effect of T-cell depletion was examined. \uff3bResult\uff3d Th1-type of antigen-specific response was not observed when patient cells were stimulated with P. acnes. Strains from sarcoidosis specimen showed a significantly higher activity for induction of IL-12 and IFN-\u03b3 for whole mononuclear cells and also for T cell-depleted population. \uff3bConclusion\uff3d The results suggested that particular P. acnes strains capable of inducing a high level of inflammatory cytokine are involved in the pathogenesis of sarcoidosis. It was postulated that P. acnes first stimulate macrophages to produce IL-12 then in turn stimulate NK cells to produce IFN-\u03b3 which may contribute to granuloma formation.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "103943", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Mochizuki, Hirofumi"}]}, {"nameIdentifiers": [{"nameIdentifier": "103944", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Mitsuyama, Masao"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": 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