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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第112巻第11号

4)Propionibacterium acnesのサイトカイン誘発能とサルコイドーシスへの関与(シンポジウム サイトカインの基礎と臨床応用, 第537回新潟医学会)

http://hdl.handle.net/10191/46335
http://hdl.handle.net/10191/46335
c71e5297-0486-472e-af89-00b80351dd41
名前 / ファイル ライセンス アクション
112(11)_680-684.pdf 112(11)_680-684.pdf (783.5 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2017-02-10
タイトル
タイトル 4)Propionibacterium acnesのサイトカイン誘発能とサルコイドーシスへの関与(シンポジウム サイトカインの基礎と臨床応用, 第537回新潟医学会)
タイトル
言語 en
タイトル 4)Propionibacterium acnesのサイトカイン誘発能とサルコイドーシスへの関与(シンポジウム サイトカインの基礎と臨床応用, 第537回新潟医学会)
言語
言語 jpn
キーワード
主題Scheme Other
主題 Propionibacterium acnes
キーワード
主題Scheme Other
主題 sarcoidosis
キーワード
主題Scheme Other
主題 cytokine
キーワード
主題Scheme Other
主題 macrophage
キーワード
主題Scheme Other
主題 Interleukin 12
キーワード
主題Scheme Other
主題 Propionibacterium acnes
キーワード
主題Scheme Other
主題 サルコイドーシス
キーワード
主題Scheme Other
主題 サイトカイン
キーワード
主題Scheme Other
主題 マクロファージ
キーワード
主題Scheme Other
主題 インターロイキン12
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Bacteriological Approach to Sarcoidosis:Difference of Cytokine-inducing Ability in Various Strain of Propionibacterium Acnes
著者 望月, 博史

× 望月, 博史

WEKO 103941

望月, 博史

Search repository
光山, 正雄

× 光山, 正雄

WEKO 103942

光山, 正雄

Search repository
著者別名
識別子 103943
識別子Scheme WEKO
姓名 Mochizuki, Hirofumi
著者別名
識別子 103944
識別子Scheme WEKO
姓名 Mitsuyama, Masao
抄録
内容記述タイプ Abstract
内容記述 Propionibacterium acnes has been implicated as the etiologic agent of sarcoidosis since the isolation of this bacterium at a high incidence from sarcoidosis specimens in 1978. However, this possibility has not been established or accepted widely yet. We have obtained the P. acnes strains isolated in that study. Based on the idea that inflammatory cytokines are involved in granuloma formation characteristic for pathology of sarcoidosis, we have compared the cytokine-inducing ability among various strains. [Method] Peripheral blood mononuclear cells were obtained from sarcoidosis patients and healthy controls. Cells were stimulated with P. acnes strains in vitro, and inflammatory cytokines were determined by using cytokine-specific EIA. The effect of T-cell depletion was examined. [Result] Th1-type of antigen-specific response was not observed when patient cells were stimulated with P. acnes. Strains from sarcoidosis specimen showed a significantly higher activity for induction of IL-12 and IFN-γ for whole mononuclear cells and also for T cell-depleted population. [Conclusion] The results suggested that particular P. acnes strains capable of inducing a high level of inflammatory cytokine are involved in the pathogenesis of sarcoidosis. It was postulated that P. acnes first stimulate macrophages to produce IL-12 then in turn stimulate NK cells to produce IFN-γ which may contribute to granuloma formation.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 112, 号 11, p. 680-684, 発行日 1998-11
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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