{"created":"2021-03-01T06:20:52.729400+00:00","id":16298,"links":{},"metadata":{"_buckets":{"deposit":"31f772c1-b481-45f3-9045-519290ebda26"},"_deposit":{"id":"16298","owners":[],"pid":{"revision_id":0,"type":"depid","value":"16298"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00016298","sets":["453:456","471:537:538:1102"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Bacteriological Approach to Sarcoidosis：Difference of Cytokine-inducing Ability in Various Strain of Propionibacterium Acnes"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1998-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"684","bibliographicPageStart":"680","bibliographicVolumeNumber":"112","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Propionibacterium acnes has been implicated as the etiologic agent of sarcoidosis since the isolation of this bacterium at a high incidence from sarcoidosis specimens in 1978. However, this possibility has not been established or accepted widely yet. We have obtained the P. acnes strains isolated in that study. Based on the idea that inflammatory cytokines are involved in granuloma formation characteristic for pathology of sarcoidosis, we have compared the cytokine-inducing ability among various strains. ［Method］ Peripheral blood mononuclear cells were obtained from sarcoidosis patients and healthy controls. Cells were stimulated with P. acnes strains in vitro, and inflammatory cytokines were determined by using cytokine-specific EIA. The effect of T-cell depletion was examined. ［Result］ Th1-type of antigen-specific response was not observed when patient cells were stimulated with P. acnes. Strains from sarcoidosis specimen showed a significantly higher activity for induction of IL-12 and IFN-γ for whole mononuclear cells and also for T cell-depleted population. ［Conclusion］ The results suggested that particular P. acnes strains capable of inducing a high level of inflammatory cytokine are involved in the pathogenesis of sarcoidosis. It was postulated that P. acnes first stimulate macrophages to produce IL-12 then in turn stimulate NK cells to produce IFN-γ which may contribute to granuloma formation.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"103943","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Mochizuki, Hirofumi"}]},{"nameIdentifiers":[{"nameIdentifier":"103944","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Mitsuyama, Masao"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"望月, 博史"}],"nameIdentifiers":[{"nameIdentifier":"103941","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"光山, 正雄"}],"nameIdentifiers":[{"nameIdentifier":"103942","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-07"}],"displaytype":"detail","filename":"112(11)_680-684.pdf","filesize":[{"value":"783.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"112(11)_680-684.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/16298/files/112(11)_680-684.pdf"},"version_id":"fc5f0737-4797-49cd-ac45-45662c87e8b7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Propionibacterium acnes","subitem_subject_scheme":"Other"},{"subitem_subject":"sarcoidosis","subitem_subject_scheme":"Other"},{"subitem_subject":"cytokine","subitem_subject_scheme":"Other"},{"subitem_subject":"macrophage","subitem_subject_scheme":"Other"},{"subitem_subject":"Interleukin 12","subitem_subject_scheme":"Other"},{"subitem_subject":"Propionibacterium acnes","subitem_subject_scheme":"Other"},{"subitem_subject":"サルコイドーシス","subitem_subject_scheme":"Other"},{"subitem_subject":"サイトカイン","subitem_subject_scheme":"Other"},{"subitem_subject":"マクロファージ","subitem_subject_scheme":"Other"},{"subitem_subject":"インターロイキン12","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"4)Propionibacterium acnesのサイトカイン誘発能とサルコイドーシスへの関与（シンポジウム サイトカインの基礎と臨床応用, 第537回新潟医学会）","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"4)Propionibacterium acnesのサイトカイン誘発能とサルコイドーシスへの関与（シンポジウム サイトカインの基礎と臨床応用, 第537回新潟医学会）"},{"subitem_title":"4)Propionibacterium acnesのサイトカイン誘発能とサルコイドーシスへの関与（シンポジウム サイトカインの基礎と臨床応用, 第537回新潟医学会）","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1102"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-02-10"},"publish_date":"2017-02-10","publish_status":"0","recid":"16298","relation_version_is_last":true,"title":["4)Propionibacterium acnesのサイトカイン誘発能とサルコイドーシスへの関与（シンポジウム サイトカインの基礎と臨床応用, 第537回新潟医学会）"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:47:52.346097+00:00"}