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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第113巻第3号

欠損を伴う末梢神経損傷の神経延長による修復法

http://hdl.handle.net/10191/46573
a55cc85a-7118-4ed3-830d-fd20a5f53aa4
名前 / ファイル ライセンス アクション
113(3)_146-158.pdf 113(3)_146-158.pdf (2.3 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2017-02-20
タイトル
タイトル 欠損を伴う末梢神経損傷の神経延長による修復法
タイトル
言語 en
タイトル 欠損を伴う末梢神経損傷の神経延長による修復法
言語
言語 jpn
キーワード
主題Scheme Other
主題 nerve injury
キーワード
主題Scheme Other
主題 defect
キーワード
主題Scheme Other
主題 tissue expansion
キーワード
主題Scheme Other
主題 autograft
キーワード
主題Scheme Other
主題 神経損傷
キーワード
主題Scheme Other
主題 欠損
キーワード
主題Scheme Other
主題 自家移植
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Nerve Repair by Elongation of the Proximal or Distal Segment Using a Tissue Expander
著者 松崎, 浩徳

× 松崎, 浩徳

WEKO 103090

松崎, 浩徳

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著者別名
識別子
識別子 103091
識別子Scheme WEKO
姓名
姓名 Matsuzaki, Hironori
抄録
内容記述タイプ Abstract
内容記述 Nerve defects, after severe injuries or resection of malignant tumors, pose difficult problems. Autologous nerve grafting has been the treatment of choice for the nerve defect;however, donor site morbidity is unavoidable and the regenerating nerve must heal through two coaptation sites. lf a nerve could be elongated safely, it may be repaired with a single coaptation site and donor site morbidity may be avoided. This study, investigating the feasibility of such a procedure, consists of two parts. In part 1, we elongated the nerve proximal to the defect using a tissue expander, and converted that injury to the injury without a gap. In part II, the nerve defect was repaired by elongation of the distal nerve segment. We compared these results with those of conventional nerve grafting. Part 1(proximal nerve elongation)Bilateral median nerves of twenty Japanese White rabbits were used. Median nerve defects were treated by elongation of proximal nerve segment on the right and by grafting on the left. The length of elongation on the right and grafting on the left was identical in each animal, and the animals were divided into 4 groups according to the length of nerve elongation or graft (group A-E: 10 mm elongation, group A-G: mm graft, group B-E: 15 mm elongation, group B-G: 15 mm graft). After healing, those nerves treated by elongation were compared functionally and histologically tb those treated by grafting. There was no significant difference in each evaluation between group A-E and group A-G. However, the group B-E was significantly inferior to group B-G. Similar results were obtained with nerve repair by proximal nerve elongation using a tissue expander for nerve injury with a smaller defect of less than 10mm (18. 2%), but, if the defect is larger than that, nerve grafting may provide better results. PartII(distal nerve elongation)The bilateral upper forelimbs of 27 Japanese White rabbits weighing 3. 5-4. 5 Kg were used. Median nerve defects were treated by elongation of distal nerve segment on the right and by grafting on the left. The length of elongation and grafting was identical in each animal, and the animals were divided into 6 groups according to the length of the defect to be repaired (group EIO: 10 mm elongation, group GIO:10mm graft, group E15: 15 mm elongation, group G15: 15 m graft, group E20: 20 mm elongation, group G20: 20mm graft). The results were evaluated functionally and histologically. The electrophysiological examination included nerve conduction velocity and flexor digitorum muscle contraction force measurement. Histologic evaluation included axon count and fiber analysis. Similar results were obtained, and there were no significant differences between the elongated and grafted groups in 10, 15, and 20 mm groups. The results of this study suggest that distal nerve elongation could be an alternative procedure for repair of nerve injury with a large nerve defect, avoiding the potential donor site morbidity from autogenous nerve.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 113, 号 3, p. 146-158, 発行日 1999-03
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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